<i>Third Prize:</i> Comparison of Radical Nephrectomy, Laparoscopic Microwave Thermotherapy, Cryotherapy, and Radiofrequency Ablation for Destruction of Experimental VX-2 Renal Tumors in Rabbits

Eichel, Louis; Kim, Issac Y.; Uribe, C.; Khonsari, Sephir; Basillote, Jay; Steward, Earl; Coad, James E.; Bischof, John C.; Rudie, Eric N.; Kluge, Stan; McDougall, Elspeth M.; Clayman, Ralph V.

doi:10.1089/end.2005.19.1082

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…In several ablate and resect studies performed in animal models [24][25][26][27][28][29], pathological and histological examinations of the renal coagulation lesion induced via RFA were carried out. On gross examination, the coagulation necrosis is blanched, well-circumscribed and of yellowish-white colour.…”

Section: Experimental Studies and Pathologymentioning

confidence: 99%

Image-guided radiofrequency ablation of renal cell carcinoma

et al. 2006

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The incidence of renal cell carcinoma is rising with the increased number of incidental detection of small tumours. During the past few years, percutaneous imaging-guided radiofrequency ablation has evolved as a minimally invasive treatment of small unresectable renal tumours offering reduced patient morbidity and overall health care costs. In radiofrequency ablation, thermal energy is deposited into a targeted tumour by means of a radiofrequency applicator. In recent studies, radiofrequency ablation was shown to be an effective and safe modality for local destruction of renal cell carcinoma. Radiofrequency applicator navigation can be performed via ultrasound, computed tomography or magnetic resonance guidance; however, ultrasound seems less favourable because of the absence of monitoring capabilities during ablation. On-line monitoring of treatment outcome can only be performed with magnetic resonance imaging giving the possibility of eventual applicator repositioning to ablate visible residual tumour tissue. Long-term follow-up is crucial to assess completeness of tumour ablation. New developments in ablation technology and radiological equipment will further increase the indication field for radiofrequency ablation of renal cell carcinoma. Altogether, radiofrequency ablation seems to be a promising new modality for the minimally invasive treatment of renal cell carcinoma, which was demonstrated to exhibit high short-term effectiveness.

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Section: Experimental Studies and Pathologymentioning

confidence: 99%

Image-guided radiofrequency ablation of renal cell carcinoma

et al. 2006

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“…Only one study, to our knowledge, has evaluated MWA, RFA, and cryoablation together. Eichel and coworkers [13] compared these therapies in an experimental renal tumor model in rabbits. They reported that carcinomatosis occurred more often in animals treated with MWA, followed by RFA, then cryoablation [13].…”

Section: Discussionmentioning

confidence: 99%

“…Eichel and coworkers [13] compared these therapies in an experimental renal tumor model in rabbits. They reported that carcinomatosis occurred more often in animals treated with MWA, followed by RFA, then cryoablation [13]. They speculated that the higher rates of carcinomatosis found in the MWA and RFA groups may be related to the boiling effect after puncture with the needle probe compared with the freezing of the cancer cells that takes place in cryoablation [13].…”

Section: Discussionmentioning

confidence: 99%

“…They reported that carcinomatosis occurred more often in animals treated with MWA, followed by RFA, then cryoablation [13]. They speculated that the higher rates of carcinomatosis found in the MWA and RFA groups may be related to the boiling effect after puncture with the needle probe compared with the freezing of the cancer cells that takes place in cryoablation [13]. A recent clinical study by Clark and coworkers was the first to evaluate zones of ablation following single and multiprobe MWA; however, only one power (60 W) and time (10 min) setting was used to create these lesions [14].…”

Section: Discussionmentioning

confidence: 99%

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Guidelines for Power and Time Variables for Microwave Ablation in an In Vivo Porcine Kidney

Hope

Schmelzer

Newcomb

et al. 2009

Journal of Surgical Research

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“…Divergent data utilizing experimental studies with VX-2 carcinoma in rabbits has been published (6,7). The few clinical studies published to date have reasonable results with a maximum follow-up of 11 months (8,9).…”

Section: Editorial Commentmentioning

confidence: 99%

Laparoscopic, ultrasound-guided microwave thermal ablation with direct, real-time temperature monitoring of a 3.4 cm renal tumor in an anti-coagulated patient

Correa¹

2010

Int. braz j urol.

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Purpose: We report the first case of a laparoscopic, ultrasound-guided microwave ablation (MWA) of a renal tumor. The case was performed in a 79 year old female with atrial fibrillation requiring anti-coagulation with successful core biopsy being performed at the same time as the ablation. Methods: A 3.4 cm right lower pole enhancing renal mass was exposed laparoscopically. A microwave ablation probe (3.7 cm active tip, Valley Lab) was positioned under direct vision and laparoscopic ultrasound guidance. Independent fiberoptic, non-conducting temperature sensors (Lumasense, CA) were placed at the deep and peripheral margins of the tumor. Core biopsies of the tumor were performed prior to beginning the ablation. The ablation was continued until all temperature sensors reached greater than 60 degrees Celsius. Results: The patient's surgery was performed using Lovenox-bridging with reinstitution of coumadin within 24 hours. There was minimal blood loss (less than 20 mol). The preoperative hematocrit was 45.8% and postoperatively 44.8%. Operative time was 56 min, of which the ablation time consisted of 10 min. There were no preoperative or postoperative complications. Follow-up CT scan of the abdomen at six weeks with and without contrast showed no post-operative hematoma and no residual enhancement. Conclusions: MWA is a safe, effective means of thermal ablation of renal tumors. Excellent hemostasis is achieved without the need for hilar dissection and clamping. Tissue ablation is effected via coagulative necrosis and the technique has been applied successfully in an anti-coagulated patient for a mesophytic tumor greater than 3 cm.Int Braz J Urol. 2010; 36 (Video #5): 249_51 Available

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Third Prize: Comparison of Radical Nephrectomy, Laparoscopic Microwave Thermotherapy, Cryotherapy, and Radiofrequency Ablation for Destruction of Experimental VX-2 Renal Tumors in Rabbits

Cited by 14 publications

References 19 publications

Image-guided radiofrequency ablation of renal cell carcinoma

Image-guided radiofrequency ablation of renal cell carcinoma

Guidelines for Power and Time Variables for Microwave Ablation in an In Vivo Porcine Kidney

Laparoscopic, ultrasound-guided microwave thermal ablation with direct, real-time temperature monitoring of a 3.4 cm renal tumor in an anti-coagulated patient

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