<i>TNF-α</i>(g.−308 G &gt; A) and<i>ADIPOQ</i>(g. + 45 T &gt; G) Gene Polymorphisms in Type 2 Diabetes and Microvascular Complications in the Region of Punjab (North–West India)

Sikka, Ruhi; Raina, Priyanka; Matharoo, Kawaljit; Bandesh, Khushdeep; Bhatia, R. Sacha; Chakrabarti, Subhabrata; Bhanwer, A.J.S.

doi:10.3109/02713683.2014.892998

Cited by 35 publications

(28 citation statements)

References 46 publications

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“…In contrast, Ma et al found no independent role of rs2241766 in nephropathy development among Swedish Caucasians [25]. Neither did in three other studies by Sikka et al, Peng et al, and Rudofsky et al, respectively [27,30,31].…”

Section: Discussionmentioning

confidence: 93%

“…During the further reviewing, 163 articles were deleted for editorials (7), on rats (6), not about DN or merely about diabetes (63), obvious irrelevancy (71), concerning the prognosis of DN (8), meta-analysis (3), and with no detailed data about genotype and allele frequencies (5). At last, 14 case-control studies with 3343 cases and 7859 controls were incorporated into the present meta-analysis [1,20,[24][25][26][27][28][29][30][31][32]. All of the controls in our meta-analysis were diabetic patients without nephropathy.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

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WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy

Zhu¹,

Zhang²,

Wang³

et al. 2017

Oncotarget

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Section: Discussionmentioning

confidence: 93%

Section: Characteristics Of Studiesmentioning

confidence: 99%

WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy

Zhu¹,

Zhang²,

Wang³

et al. 2017

Oncotarget

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“…However, the values of lipid parameters were not significantly different between T2D and control subjects in Jat Sikhs. These variations might be observed due to consumption of saturated fat and intensive lifestyle modifications and ethnic differences (Arnold et al 2009;Matharoo et al 2013;Sikka et al 2014). The increased fat consumption makes it harder for the body to absorb fat from the blood which might in turn increase the blood glucose concentrations and cause the liver to become resistant to insulin.…”

Section: Discussionmentioning

confidence: 99%

Association of genetic variants in INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) with type 2 diabetes (T2D): a case–control study in three ethnic groups from North-West India

et al. 2015

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Genetic contributions towards Type 2 diabetes (T2D) have been assessed through association studies across different world populations with inconsistencies. The majority of the T2D susceptibility loci are common across different races or populations but show ethnicity-specific differences. The pathogenesis of T2D involves genetic variants in the candidate genes. The interactions between the genes involved in insulin signaling and secretory pathways are believed to play an important role in determining an individual's susceptibility towards T2D. Therefore, the present study was initiated to examine the differences, if any, in the contribution of polymorphisms towards T2D susceptibility in the background of different ethnic specifications. The present case-control study included a total of 1216 T2D cases and healthy controls from three ethnic groups (Jat Sikhs, Banias and Brahmins) of North-West India. Polymorphisms were selected on the basis of information available in the literature for INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) in context to T2D. The genotyping was done using PCR-RFLP method. Statistical analysis was done using SPSS 16.0. The analyses revealed that INS (rs689) polymorphism conferred risk towards T2D susceptibility in all the three ethnic groups whereas INSR (rs1799816) polymorphism conferred risk towards T2D in Brahmins only and PP1G.G (rs1799999) polymorphism indicated T2D risk in Jat Sikhs only. Furthermore, interaction analyses indicated the cumulative role of three genetic variants in modulating T2D susceptibility in the three ethnic groups. In conclusion, our results substantiated the evidences for the role of ethnicity in differential susceptibility to T2D in the background of same genetic variants.

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“…A previous study had shown association of this SNP to DR but in conjunction with another gene polymorphism found in the ADIPOQ gene (rs2241766) (Sikka et al. ). Yoshioka et al.…”

Section: Chronic Hyperglycaemiamentioning

confidence: 86%

“…However, Sikka et al. () found an association with the TT genotype of rs2241766 in their cohort of Punjabi patients with DR.…”

Section: Chronic Hyperglycaemiamentioning

confidence: 90%

Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

Broadgate

Kiire

Halford

et al. 2018

Acta Ophthalmologica

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Diabetic retinopathy, a complication of both type 1 and type 2 diabetes, is a complex disease and is one of the leading causes of blindness in adults worldwide. It can be divided into distinct subclasses, one of which is diabetic macular oedema. Diabetic macular oedema can occur at any time in diabetic retinopathy and is the most common cause of vision loss in patients with type 2 diabetes. The purpose of this review is to summarize the large number of genetic association studies that have been performed in cohorts of patients with type 2 diabetes and published in English-language journals up to February 2017. Many of these studies have produced positive associations with gene polymorphisms and diabetic retinopathy. However, this review highlights that within this large body of work, studies specifically addressing a genetic association with diabetic macular oedema, although present, are vastly under-represented. We also highlight that many of the studies have small patient numbers and that meta-analyses often inappropriately combine patient data sets. We conclude that there will continue to be conflicting results and no meaningful findings will be achieved if the historical approach of combining all diabetic retinopathy disease states within patient cohorts continues in future studies. This review also identifies several genes that would be interesting to analyse in large, well-defined cohorts of patients with diabetic macular oedema in future candidate gene association studies.

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TNF-α(g.−308 G > A) andADIPOQ(g. + 45 T > G) Gene Polymorphisms in Type 2 Diabetes and Microvascular Complications in the Region of Punjab (North–West India)

Abstract: Our results indicated a higher risk of T2D and DR in the background of ADIPOQ TT genotype. Further, the ADIPOQ g. + 45 T > G and TNF-α g. - 308 G > A polymorphisms jointly give 1.45-fold risk towards T2D.

Cited by 35 publications

References 46 publications

WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy

WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy

Association of genetic variants in INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) with type 2 diabetes (T2D): a case–control study in three ethnic groups from North-West India

Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

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