<i>Toxoplasma gondii</i>infection in pregnant women in China

Gao, Xiao-Jie; Zhao, Zhanzheng; He, Zuyong; Wang, Tengyao; Yang, Tianqi; Chen, X.-G.; Shen, Jilong; Wang, Yishuang; Hide, Geoff; Zhao, Lun

doi:10.1017/s0031182011001880

Cited by 56 publications

(58 citation statements)

References 29 publications

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“…The 82.3 % Toxoplasma IgG positive and lgM negative results obtained in this study was similar with study from Jimma town, Ethiopia [25] and higher than those studies reported from Central Ethiopia [16] and elsewhere in the world [36–40]. In this study, 3.02 % of enrolled pregnant women had detectable IgM antibodies during pregnancy with potential risk of congenital T. gondii infection warranting attention to design preventive measures.…”

Section: Discussionsupporting

confidence: 88%

Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women following antenatal care at Mizan Aman General Hospital, Bench Maji Zone (BMZ), Ethiopia

Abamecha

Awel

2016

BMC Infect Dis

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BackgroundThe intracellular parasite, Toxoplasma gondii (T.gondii) is found worldwide. Infection with T. gondii during pregnancy can result in fetal and neonatal death or various congenital defects. A serological survey during pregnancy represents a valuable tool for the effective diagnosis and treatment of infected neonates. The aim of this study was to assess the sero-prevalence and risk factors of T.gondii in pregnant women following ante natal care (ANC) services at Mizan Aman General Hospital, Bench Maji zone (BMZ), Ethiopia.MethodsAn institution based cross-sectional study was conducted enrolling a sample of 232 pregnant women attending antenatal care at Mizan Aman General Hospital during 01 December, 2014 to 18 February, 2015. Systematic random sampling technique was used to obtain the required sample. About 5 ml of blood sample was collected aseptically by using properly labeled plain tube with the necessary information. The blood samples centrifuged at 3000 rpm for 10 min to separate serum. The serum was stored at a temperature of 20 °C below zero until the serological analysis was done for the presence of anti T.gondii antibodies (i.e. Immune globulin ‘M’ (IgM) and Immune globulin ‘G’ (IgG)) using enzyme linked immunosorbent assay (ELISA). Exit interview was conducted with eligible mothers to obtain socio-demographic and behavioral data using structured questionnaires. Multivariate logistic regression modeling was employed to identify the potential predictor variables for T.gondii infection. P-value less than 5 % was considered to declare a sound significant association.ResultsThe response rate of the study was 100 %. The overall sero-prevalence for T.gondii infection was 85.3 % (198/232). About 191 (82.3 %) of the pregnant women were reactive only for IgG anti-bodies. While about 7 (3.0 %) of them were seropositive for both IgG and IgM anti-bodies. None of the mothers were positive for IgM anti-bodies exclusively. On multivariate logistic regression analysis, contact with cat and gardening soil were significantly associated with T.gondii infection (AOR =2.37, 95 % CI = [1.16, 3.57] and AOR = 2.49, 95 % CI = [1.53, 3.86] respectively.ConclusionsSero-prevalence of T. gondii antibodies for IgM was relatively high among pregnant women. Contact with cat and soil were risk factors for T.gondii case. Creating awareness on the source of infection, modes of transmission and prevention of T. gondii should be given for pregnant women. Routine screening services for T. gondii infection should be integrated with other ANC services to identify potential infections of the parasite.

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Section: Discussionsupporting

confidence: 88%

Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women following antenatal care at Mizan Aman General Hospital, Bench Maji Zone (BMZ), Ethiopia

Abamecha

Awel

2016

BMC Infect Dis

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“…Acute infection with T. gondii during pregnancy and its potentially tragic outcome for the fetus and newborn continue to occur worldwide (21), with a significant proportion of pregnancies being at risk (32,33). Toxoplasmosis is being recognized with increased frequency, especially in patients with AIDS (34).…”

Section: Discussionmentioning

confidence: 99%

Infection by Toxoplasma gondii , a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia

Guo

Gao

Luo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The airway epithelia initiate and modulate the inflammatory responses to various pathogens. The cystic fibrosis transmembrane conductance regulator-mediated Cl − secretion system plays a key role in mucociliary clearance of inhaled pathogens. We have explored the effects of Toxoplasma gondii, an opportunistic intracellular protozoan parasite, on Cl − secretion of the mouse tracheal epithelia. In this study, ATP-induced Cl − secretion indicated the presence of a biphasic short-circuit current (I sc ) response, which was mediated by a Ca 2+ -activated Cl − channel (CaCC) and the cystic fibrosis transmembrane conductance regulator. However, the ATP-evoked Cl − secretion in T. gondii-infected mouse tracheal epithelia and the elevation of [Ca 2+ ] i in T. gondii-infected human airway epithelial cells were suppressed. Quantitative reverse transcription-PCR revealed that the mRNA expression level of the P2Y2 receptor (P2Y2-R) increased significantly in T. gondii-infected mouse tracheal cells. This revealed the influence that pathological changes in P2Y2-R had on the downstream signal, suggesting that P2Y2-R was involved in the mechanism underlying T. gondii infection in airways. These results link T. gondii infection as well as other pathogen infections to Cl − secretion, via P2Y2-R, which may provide new insights for the treatment of pneumonia caused by pathogens including T. gondii.

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“…In an immunocompetent host, infection is generally chronic and asymptomatic, as the immune system keeps T. gondii confined to cysts and the intracellular space within the muscle and brain. Primary infection in pregnant women can be transmitted to the fetus leading to miscarriage or congenital toxoplasmosis [116]. T. gondii, is diagnosed mainly by serological methods that are hindered by insufficient sensitivity.…”

Section: Toxoplasma Infectionmentioning

confidence: 99%

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Ibrahim¹

2013

Anat Physiol

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Trace elements have a major role as both oxidants and antioxidants, promoting and protecting from tissue damage respectively. As the liver has a pivotal role in trace elements metabolism and consequenyly their bioavailability, we aimed to measure serum levels of essential trace elements in children with chronic liver diseases (CLDs) regardless the etiology and to study their correlation with liver function tests. Serum zinc (Zn), copper (Cu) and iron (Fe); together with other trace elements parameters; were measured in 50 children with CLDs using spectrophotometry and their levels were compared with those age and sex matched healthy children as controls. Serum Cu, Fe, ferritin and transferrin saturation (TS) were significantly higher in the CLDs group than that in the control group; while serum Zn and total iron binding capacity (TIBC) were significantly lower in the CLDs than that in the control group. Serum Fe, Cu, TS and ferritin were positively correlated with biochemical parameters of liver damage; while serum Zn and TIBC were negatively correlated with biochemical parameters of liver damage. These results encourage inclusion of serum Zn, Cu and Fe as biomarkers for monitoring the severity of liver damage during routine assessment of children with CLDs. We recommended caution to avoid excess Fe and Cu intake in children with CLDs. Moreover, Zn supplementation could be encouraged in children with CLDs regardless its etiology.

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Toxoplasma gondiiinfection in pregnant women in China

Cited by 56 publications

References 29 publications

Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women following antenatal care at Mizan Aman General Hospital, Bench Maji Zone (BMZ), Ethiopia

Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women following antenatal care at Mizan Aman General Hospital, Bench Maji Zone (BMZ), Ethiopia

Infection by Toxoplasma gondii , a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

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