Toxoplasma gondiiROP18 Inhibits Human Glioblastoma Cell Apoptosis through Mitochondrial Pathway by Targeting Host Cell P2X1

Abstract

13It is known that Toxoplasma gondii infection both initiates and inhibits host cell P2X1 expression, which may indicate that ROP18's inhibition of host cell apoptosis is 25 related to P2X1. Interestingly, we further identified that ROP18 (RH strain) interacted 26 with P2X1, and over-expression of ROP18 in COS-7 cells inhibited the cell apoptosis 27 mediated by P2X1. We also found that ROP18 of RH strain inhibited P2X1-mediated 28 Ca 2+ influx, translocation of cytochrome C from mitochondria to cytoplasm, and . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.