trans- andcis-S—C—C—S Conformations in 5-(2,2'-Dithien-5-yl)-2'-deoxyuridine

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels

“…This type of attractive intramolecular interaction between a thiazole or thiazolidine S and an adjacent carbonyl O at four bonds distance has been observed before and can be viewed simplistically as a Coulombic attraction between the positively charged S and the negatively charged O 41b. Similar CO...S stabilizing interactions have been proposed from the crystal structures of analogous 1,3,4-thiadiazoles 41b and 2-thiophenes 1 X-ray crystal structure of 13d (hydrogens omitted for clarity). …”

2-Amino-4-methylthiophene-3-carbonitrile

“…The S-C bond lengths, 1.728 (4) and 1.725 (4) Å, are in good agreement with those in the literature, e.g. 1.734 (2) and 1.721 (3) Å (Han & Choi, 2000), 1.727 (1) and 1.729 (2) Å (Elerman & Elmalı, 1998), and 1.723 (2) and 1.735 (3) Å (Wouters et al, 1997). The C1≡N1 bond distance is 1.153 (4) Å, typical of such a triple bond.…”

Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities

“…It also has an influence on the electronic distribution all over the molecule, which might modulate biological activity as already described [40]. The higher potency in the 2,5-thiophene class might also indicate that no intramolecular coulombic attraction between the S(thiophene)-O(carbonyl) occurs as already described in thiophene GABA receptor ligands [42] and other thiophenes acting on different targets [43]. All the changes undertaken to modify the central core have been ineffective for the improvement of the potency of the compounds on the human and mouse enzymes (change of the S position in the ring with respect to the two substituents and introduction of an N atom, exchanging the thiophene by a thiazole).…”