<i>Trans</i> fatty acids from milk of Brazilian mothers of premature infants

Tinoco, Sandra Manzato Barboza; Sichieri, Rosely; Setta, Cecília L; Moura, Aníbal Sanchez; Carmo, Maria das Graças Tavares do

doi:10.1111/j.1440-1754.2007.01172.x

Cited by 21 publications

(23 citation statements)

References 41 publications

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“…In our study, the breast milk ratio of LA to ALA was 23 to 1, which might explain the higher AA levels. This is in agreement with observations of variable ratios of LA to ALA in colostrum from mothers of preterm and full-term infants 18 . Excess LA downregulates ALA metabolism into its LCPUFA because it competes with ALA for desaturation 24 .…”

Section: Commentsupporting

confidence: 93%

“…We found that breast milk from the first week postpartum contained an elevated ratio of LA to ALA that was positively associated with measures of receptive language. Our study found similar percentages of LCPUFA in the milk from mothers of preterm infants to a previous study conducted in Brazil 18 and higher values compared to other studies in different countries 19 . Specifically, the values of AA in the present study (0.4%) were slightly above the worldwide mean value of 0.32% (SD 0.22) 20 .…”

Section: Commentsupporting

confidence: 87%

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Preterm infant language development: a role for breast milk fatty acids

Toro‐Ramos

Méio²,

Morsch³

et al. 2013

J. Hum. Growth Dev.

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Premature infants have an increased risk of developmental disabilities during infancy and childhood. A crucial period of fetal polyunsaturated fatty acid accretion bypassed with prematurity. Objective: to study how the fatty acid composition of breast milk in breast-fed premature infants is associated with cognitive, language, and motor development. Methods: participants included twenty-five healthy preterms, born adequate for gestational age at the Fernandez Figueira Institute, Rio de Janeiro, Brazil. Fatty acid composition of breast milk samples from the first week postpartum was analyzed using gas-liquid chromatography. Bayley-III developmental scales were applied at 9 or 12 months corrected age. Results: regression analyses revealed that the ratio of linoleic acid to alpha-linolenic acid was positively associated with receptive language development (â = 1.49, p = 0.03). Women with preterm infants showed breast milk long chain polyunsaturated fatty acids concentrations consistent with worldwide levels and a high ratio of linoleic acid to alpha-linolenic acid that might be beneficial for language development in the premature infant.Conclusion: a higher ratio of linoleic to alpha-linolenic acid in breast milk could exert beneficial effects for receptive language development in preterm infants fed breast milk. Larger adequately powered longitudinal studies are recommended to better understand the breast milk composition of this population and its association to developmental indices during infancy.

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Section: Commentsupporting

confidence: 93%

Section: Commentsupporting

confidence: 87%

Preterm infant language development: a role for breast milk fatty acids

Toro‐Ramos

Méio²,

Morsch³

et al. 2013

J. Hum. Growth Dev.

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“…Fatty acids were separated using an SP 2560 capillary column (Supelco, USA), with 100 m × 0.25 mm × 0.20 μm measurements. The chromatographic conditions were similar to those described by Tinoco et al [55]. The esters were identified by comparing their retention times to known standards (Sigma, Supelco).…”

Section: Methodsmentioning

confidence: 99%

Composition of fatty acids in the maternal and umbilical cord plasma of adolescent and adult mothers: relationship with anthropometric parameters of newborn

et al. 2012

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BackgroundConsidering the importance of long chain polyunsaturated fatty acids to fetal development and the lack of studies that have compared the status of fatty acids between adolescents and adults mothers, the purpose of this study was to evaluate the composition of fatty acids in maternal and umbilical cord plasma from adolescent and adults mothers.MethodsForty pregnant adolescents and forty pregnant adults were selected to assess the distribution profile of fatty acids in the maternal and umbilical cord plasma. Quantification of fatty acids in the total lipids of the sample groups was performed through the use of gas-liquid chromatography.ResultsThe maternal and umbilical cord plasma of the adolescents showed a greater concentration of AA than did that of the adults (P < 0.05). However, a greater percentage of EPA was found in the umbilical cord plasma of the adults (P < 0.05). DHA in the plasma of the adolescent mothers correlated positively to birth weight and head circumference.ConclusionsThis suggests that in situations of greater nutritional risk, as in adolescent pregnancy, n-3PUFA concentrations have a greater influence on the proper development of newborns. Moreover, variations in fatty acid concentrations in the maternal and cord plasma of adolescents and adults may indicate that pregnancy affects the LC-PUFA status of adults and adolescents in distinct ways.

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“…Fatty acids were separated using an SP 2560 capillary column (Supelco, USA), with 100 m × 0.25 mm × 0.20 μ m measurements. The chromatographic conditions were similar to those described by Tinoco et al [23]. The methylated fatty acids were identified by comparing their retention times to known standards (Nu-Chek Prep.…”

Section: Methodsmentioning

confidence: 99%

Effects of a Diet Enriched with Polyunsaturated, Saturated, or Trans Fatty Acids on Cytokine Content in the Liver, White Adipose Tissue, and Skeletal Muscle of Adult Mice

Santos

Estadella

Hachul

et al. 2013

Mediators of Inflammation

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This study analyzed the effect of diet enriched with 30% lipids on cytokines content in different tissues. Swiss male mice were distributed into four groups treated for 8 weeks with control (C, normolipidic diet); soybean oil (S); lard (L); and hydrogenated vegetable fat (H). We observed an increase in carcass fat in groups S and L, and the total amount of fatty deposits was only higher in group L compared with C group. The serum levels of free fatty acids were lower in the L group, and insulin, adiponectin, lipid profile, and glucose levels were similar among the groups. IL-10 was lower in group L in mesenteric and retroperitoneal adipose tissues. H reduced IL-10 only in retroperitoneal adipose tissue. There was an increase in IL-6 in the gastrocnemius muscle of the L group, and a positive correlation between TNF-α and IL-10 was observed in the livers of groups C, L, and H and in the muscles of all groups studied. The results suggested relationships between the quantity and quality of lipids ingested with adiposity, the concentration of free fatty acids, and cytokine production in white adipose tissue, gastrocnemius muscle, and liver.

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Trans fatty acids from milk of Brazilian mothers of premature infants

Abstract: The study showed that the intake of TFA occupies an intermediate position between the values of North America and European countries, reflecting the ongoing transition to industrialised foods in Brazil.

Cited by 21 publications

References 41 publications

Preterm infant language development: a role for breast milk fatty acids

Preterm infant language development: a role for breast milk fatty acids

Composition of fatty acids in the maternal and umbilical cord plasma of adolescent and adult mothers: relationship with anthropometric parameters of newborn

Effects of a Diet Enriched with Polyunsaturated, Saturated, or Trans Fatty Acids on Cytokine Content in the Liver, White Adipose Tissue, and Skeletal Muscle of Adult Mice

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