Trichosporon inkin Peritonitis Treated with Caspofungin

Abstract

Trichosporon inkin is one of six pathogenic species of the genus Trichosporon and the etiologic agent of pubic white piedra. Trichosporon species have been reported as a cause of disseminated infections, particularly among immunosuppressed patients. We describe the third reported case of T. inkin peritonitis associated with peritoneal dialysis and the first to be treated with caspofungin.

Molecular Identification and Susceptibility ofTrichosporonSpecies Isolated from Clinical Specimens in Qatar: Isolation ofTrichosporon dohaenseTaj-Aldeen, Meis & Boekhout sp. nov

“…inkin is frequently isolated from clinical specimens (66), such as white piedra (13,23,76), but also from patients with peritonitis (12,36,37), endocarditis (61), lung abscesses (60), subcutaneous nodules (rheumatoid arthritis patients receiving corticosteroid therapy) (65), sternal surgical wound infections (13), and invasive infections (31,82). In the present study, T. inkin was isolated in cases of white piedra, balanitis, and urethral discharge.…”

“…The formation of blastoconidia was also investigated using these media. Growth at different temperatures (25,30,35,37,40, and 42°C) was evaluated using inoculated YPGA slants placed in incubators at the appropriate temperatures. The nutritional requirements, fermentative capabilities, reactions to diazonium blue B, and urease activities of the yeast strains were assessed according to the work of Yarrow (83).…”

The development of animal infection models and antifungal efficacy assays against clinical isolates ofTrichosporon asahii,T. asteroidesandT. inkin

“…However, a common trend exists for the use of azoles, and specially VRC, rather than AMB or the echinocandins, 2 although some clinical reports have described the efficacy of CAS against T. inkin when used solely or in combination with AMB. 48,49 Over recent years several non-vertebrate animal models have emerged as an alternative to the mammalian models of fungal infection. These models represent a powerful tool to study fungal pathogenesis, the efficacy of antifungal compounds, and innate antifungal immunity.…”

Invasive Infections Caused byTrichosporonSpecies andGeotrichum capitatumin Patients with Hematological Malignancies: a Retrospective Multicenter Study from Italy and Review of the Literature

“…The 287 infections we assigned to the category of Trichosporon spp. included 28 cases (all reported after 1995) in which the yeast was identified, in accordance with the revised classification, as T. asahii (17 infections, including 10 in patients with hematological diseases) (1,16,26,36,58,81,84,98,131,132, plus 6 cases from the present series); T. inkin (5 infections, 2 in patients with hematological malignancies) (19,72,74,84,104); T. mucoides (4 infections, none involving patients with hematological malignancies) (45,92); and T. cutaneum or T. asteroides (each responsible for 1 infection, both involving patients with hematological malignancies) (18,66). The vast majority of G. capitatum and T. pullulans infections occurred in patients with hematological disease (91.7 and 75%, respectively).…”