Ulerythema Ophryogenes, a Rare and Often Misdiagnosed Syndrome: Analysis of an Idiopathic Case

Abstract

Keratosis pilaris (KP) is a follicular hyperkeratosis disorder which is frequently detected in the adult population (44%), mostly in female adolescents (80%). It is a genetic autodominant dermatosis with variable penetrance, but no specific gene association has been determined, even though association to the presence of chromosome 18p deletion has been reported in some cases. We report the case of a 51-year-old Caucasian woman affected by keratosis pilaris gradually progressing with age and with a story of multiple abortions. Standard karyotype and CGH array analyses did not reveale any genetic abnormality. Virological analyses detected the presence of HPV 36 DNA inside the dorsum biopsy, leading to hypothesize its involvement in the evolution of the lesion. Clinical history and patient examination led the diagnosis of an idiopathic case of Ulerythema ophryogenes. The analysis of more cases could be useful to verify the involvement of cutaneous HPV in the progression of the clinical manifestation of the KP variants.

Calcium Ionophore A23187 and Compound 48/80 Induce PGD2 and Tryptase in Human Cord Blood-Derived Mast Cells: Lack of Effect of IL-18

“…Considerable attention has recently been devoted to the study ofcytokines, and in particular IL-l family mechanisms having the ability to induce biological activities on mast cells. One of the hypotheses is that IL-18 activates several cells through its receptor, including monocytes, lymphocytes basophils and mast cells (41,(58)(59)(60)(61)(62). Since IL-I stimulates PGE2 in macrophages, we hypothesize that IL-18 stimulates arachidonic acid in human mast cells and then may affect the production of prostaglandins such as PG0 2.…”

Impact of Immunity in Autism Spectrum Disorders

“…Many authors reported that cytokine imbalances in autism have pathological roles and have important interaction with the nervous system, contributing to the dysfunction in autism spectrum disorders (8)(9)(10)(11)(12).…”

“…Several authors have reported that elevated cytokines in the cerebral spinal fluid of living autistic children play an important role in the neuroinflammatory process linked to this disease(s). Many authors reported that cytokine imbalances in autism have pathological roles and have important interaction with the nervous system, contributing to the dysfunction in autism spectrum disorders (8)(9)(10)(11)(12).…”