<i>Ureaplasma</i> species and preterm birth: current perspectives

Sprong, K E; Mabenge, Mfundo; Wright, Colleen A.; Govender, Sharlene

doi:10.1080/1040841x.2020.1736986

Cited by 70 publications

(56 citation statements)

References 93 publications

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“…Amplicon libraries of the V1-V2 region of the 16S rDNA were sequenced on a MiSeq system (2 × 250 bp; Illumina, Hayward, CA), and merged and aligned reads were clustered allowing differences in two nucleotides [25,26] An ascending amnion infection of Ureaplasma spp. with the possibility of vertical transmission in utero or perinatally is possible [27][28][29]. Ureaplasma spp., especially Ureaplasma parvum [8,9], is frequently observed in preterm and very-low-birth-weight neonates [8,11].…”

Section: Discussionmentioning

confidence: 99%

“…impact factors like the immature immunological processes of a preterm infant, is discussed as the mutual underlying mechanism in prenatal, perinatal and neonatal morbidities [12,23,27]. Especially Ureaplasma parvum serovars seem to increase the risk of spontaneous preterm birth [30].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the optimal indications for treatment as well as treatment regimens itself of both maternal and neonatal Ureaplasma colonization or infection is poorly defined. Eradication approaches have not proven successful so far, and standardized regimens are lacking [12,27,39].…”

Section: Discussionmentioning

confidence: 99%

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Lethal Neonatal Respiratory Failure by Perinatal Transmission of Ureaplasma Parvum after Maternal PPROM

Zöllkau

Pieper

Pastuschek

et al. 2020

Z Geburtshilfe Neonatol

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A primiparous pregnant woman was admitted due to preterm premature rupture of membranes (PPROM) at 27+0 week of gestational age (WGA). Conventional vaginal microbiological analysis had no pathological finding. Management decisions based on national guidelines included antenatal corticoids, tocolytics and antibiotics. Unstoppable efforts of preterm labor in 28+0 WGA and supposed amniotic infection syndrome necessitated emergency cesarean section. The preterm infant underwent NICU therapy, developed an early-onset neonatal sepsis and therapy-refractory pulmonary insufficiency with consecutive right heart failure, resulting in death on the 36th day of life. Microbiota analyses by 16Sr DNA sequencing was performed from maternal vaginal swabs and from neonatal pharyngeal swabs. Maternal antibiotic treatment resulted in depletion of physiological vaginal colonization with Lactobacillus crispatus. Ureaplasma parvum became the dominant vaginal microorganism at delivery and was detected in high relative abundance in the neonatal specimen. Progressive radiological air-space changes and interstitial pathologies associated with Ureaplasma infection (bronchopulmonary dysplasia type III) were seen early at the 3rd and distinctly from 14th day of life. This clearly demonstrates the need of vaginal colonization diagnostics in PPROM patients and awareness of the consecutive risks in the preterm. Vaginal microbiome analysis may allow individualized and targeted maternal and fetal diagnostic, prophylactic and therapeutic strategies to identify, protect and treat the high-risk neonates after PPROM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lethal Neonatal Respiratory Failure by Perinatal Transmission of Ureaplasma Parvum after Maternal PPROM

Zöllkau

Pieper

Pastuschek

et al. 2020

Z Geburtshilfe Neonatol

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“…Preterm doğumu tetikleyen en sık etkenin Ureaplasma'lar olduğu bilinmektedir. 48,[53][54][55][56][57] FETAL İNFLAMATUAR YANIT SENDROMUNDA ORGAN TUTULUMLARI FIRS, fetal beyin, akciğer, böbrek, kalp, gastrointestinal sistem ve adrenal beze olumsuz etkileriyle fetal yaşamı kısaltan çoklu organ harabiyetidir.…”

Section: öLü Doğumunclassified

Chorioamnionitis and Its Fetal Effects

Ongun¹,

Çelik²,

Oygür³

2020

Turkiye Klinikleri J Pediatr

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Koryoamniyonit, gebelik sırasında amniyotik sıvı, umbilikal kordon ve fetal membranların enfeksiyonu ve/veya inflamasyonunu içermekte ve anne açısından endometrit, pelvik tromboflebitis, pelvik apse, postpartum kanama, fetüs açısından fetal inflamatuar yanıt sendromu [fetal inflammatory response syndrome (FIRS)], doğan bebek için erken sepsis, konjenital pnömoni, perinatal ölüm, prematüre retinopatisi, bronkopulmoner displazi [bronchopulmonary dysplasia (BPD)], intraventriküler kanama (İVK), nekrotizan enterokolit [necrotizing enterocolitis (NEC)], serebral palsi [cerebral palsy (CP)] gibi

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“…urealyticum, U. parvum and Mycoplasma hominis are most frequently isolated from the amniotic fluid and placenta in cases of histologic and clinical chorioamnionitis and in association with spontaneous preterm labor (PTL) and PPROM (ref. 13 ). In addition, HCA is associated with a high concentration of inflammatory mediators in amniotic fluid, including proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) (ref.…”

Section: Introductionmentioning

confidence: 99%

Transabdominal amniocentesis in expectant management of preterm premature rupture of membranes: A single center prospective study

Fulova¹,

Hostinská²,

Studničková³

et al. 2021

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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The aim of this study was to evaluate the role of IL-6 point-of-care test in amniotic fluid obtained from serial amniocentesis in expectantly managed women with PPROM between 24 and 34 weeks of gestation. Methods. We conducted a prospective observational cohort study which included 62 pregnant women with PPROM in gestational weeks between 22+0 and 34+0. Women aged >18 years were eligible if they presented with PPROM and a singleton pregnancy. Only women who delivered at >24.0 weeks were included in the study. In all women, the maternal blood sampling and a transabdominal amniocentesis were performed at the time of admission prior to the administration of corticosteroids, antibiotics, or tocolytics, to rule out signs of chorioamnionitis. Maternal temperature, maternal serum C-reactive protein (CRP) and white blood cell (WBC) counts were assayed every subsequent day until delivery. Amniotic fluid was used for the clinical assessment (IL-6 point-of-care test, identification of microorganisms in the amniotic fluid. After one week of expectant management of PPROM, second amniocentesis with amniotic fluid sampling was performed in patients who did not deliver. For all newborns, medical records regarding neonatal morbidity and mortality were reviewed. Results. In total, 62 women aged 19 to 41 years were recruited in the study. The mean gestational age at the time of PPROM was 31+0, the mean gestational age at labor was 32+1, and the median time from PPROM to childbirth was 112 h. IL-6 point-of-care test values above 1,000 pg/mL (positive Il-6 AMC) were found in 12 women (19.4%) with median interval from PPROM to childbirth 56 h (min-max: 6.4-288). IL-6 point-of-care test values below 1,000 pg/mL (negative Il-6 AMC) were found in 51 women (81.0%). The neonatal mortality rate was 1.9% and was associated with prematurity. Conclusion. The major clinical finding of our study is that serial transabdominal amniocentesis with Il-6 point-of-care test helps to identify a high inflammatory status in amniotic fluid in women with PPROM. Subsequent expectant management of women with PPROM does not lead to worsening of short-term neonatal outcomes.

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Ureaplasma species and preterm birth: current perspectives

Cited by 70 publications

References 93 publications

Lethal Neonatal Respiratory Failure by Perinatal Transmission of Ureaplasma Parvum after Maternal PPROM

Lethal Neonatal Respiratory Failure by Perinatal Transmission of Ureaplasma Parvum after Maternal PPROM

Chorioamnionitis and Its Fetal Effects

Transabdominal amniocentesis in expectant management of preterm premature rupture of membranes: A single center prospective study

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