I.v. tenoxicam for analgesia during Caesarean section

Abstract

We have studied the analgesic efficacy of a single i.v. dose of tenoxicam 20 mg, given 10 min before induction of anaesthesia in 25 patients undergoing elective Caesarean section. Another group of 25 similar patients served as controls. Nalbuphine consumption in the first 24 h after operation was reduced by 50% when tenoxicam was given. The median time to first request for analgesia was increased from 25 to 110 min in the tenoxicam group. Subjective experiences of pain and sedation were significantly greater in the control group up to 24 h after operation. The haemodynamic variability after intubation was of shorter duration in the tenoxicam group. There was no significant difference in incidence and severity of postoperative nausea and vomiting between the two groups. The surgeon's assessment of uterine relaxation and bleeding, using a visual analogue score, and infant well-being, as judged by Apgar score and cord blood-gas analysis, showed no significant difference between the two groups. There was no evidence of premature closure of the ductus arteriosus or pulmonary hypertension. We conclude that a single i.v. dose of tenoxicam is a useful pretreatment to minimize the haemodynamic variability of light general anaesthesia at induction-delivery and in reducing 24 h postoperative opioid consumption.

Perioperative intravenous flurbiprofen reduces postoperative pain after abdominal hysterectomy

“…These results are in agreement with other studies which found no significant increase in bleeding associated with NSAID administration. 1,2,6 We conclude that the intravenous administration of flurbiprofen during anesthesia is effective in reducing postoperative rescue analgesic requirement. Moreover, preoperative flurbiprofen will diminish postoperative pain in a preemptive manner.…”

“…Elhaki and Nafie 6 showed that intravenous tenoxicam before induction of anesthesia reduced postoperative opioid consumption after Cesarean section. A recent report by Rømsing et al 7 also demonstrated that, for tonsillectomy, preoperative intravenous ketorolac reduced the postoperative use of fentanyl more than postoperative administration.…”

“…5 The preemptive efficacy of NSAIDs is controversial: not all studies have reported benefit. [5][6][7][8] We investigated whether flurbiprofen iv, given in a preemptive manner, reduce postoperative pain after abdominal hysterectomy .…”

Anaesthesia for daycase gynaecological laparoscopy: a survey of clinical practice in the United Kingdom

“…Tenoxicam is an NSAID which can be delivered via the intravenous route. It is a potent analgesic and has an established efficacy in the relief of postoperative pain [18][19][20]. Because of its long half-life (60 h), once daily administration is sufficient.…”

“…A number of studies have investigated a variety of local anaesthetic techniques in patients undergoing gynaecological laparoscopy [6,7,[17][18][19][20][21]. Seventy-four respondents to our survey used wound infiltration, but despite the simplicity, efficacy and apparent safety of the intraperitoneal administration of local anaesthetic, only 34 did so routinely.…”