<i>Viscum monoicum</i>: A New Source of Polyphenolic Compounds Responsible for Antioxidant and Anti-Inflammatory Activities

Ahmed, Khondoker Shahin; Farzana, Maisha; Rahman, Shaikh Emdadur; Jahan, Israt; Khan, Tanzir Ahmed; Al-Mansur, Muhammad Abdullah; Sultana, Nadia; Hossain, Hemayet

doi:10.1080/10496475.2023.2182394

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…In addition, this author suggest that not only phenolic compounds identified in V. album L., but also visartisides (a novel class of antioxidant) have antioxidative properties, which may play an important role in the cardioprotective action of mistletoe, although further studies concerning the mechanisms of their action are necessary. Other species of mistletoe, including Chinese mistletoes and Asian mistletoes have also antioxidant potential, which was assigned to phenolic compounds, especially flavonoids ( Li et al, 2018 ; Ahmad et al, 2023 ). More details about the antioxidant activity of mistletoes are described in the review paper by Nicoletti (2023b) .…”

Section: Cardioprotective Action Of Mistletoe and Mechamisms Of Actio...mentioning

confidence: 99%

The cardioprotective potential of selected species of mistletoe

Olas

2024

Front. Pharmacol.

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Mistletoe is an evergreen woody shrub with stems measuring 30–100 cm. It has leathery, yellowish-green strap-shaped leaves, yellowish-green flowers, and bears typical berries. The most common species is Viscum album L., mainly present in Europe and Asia. It is commonly known as European mistletoe or simply, mistletoe. Scientific interest in mistletoe was awakened in the XX century. Mistletoe, especially V. album L., has historically been used in the treatment and prophylaxis of CVD, with its properties being confirmed in recent studies. This mini-review describes new aspects of the cardioprotective properties of various species of mistletoe, especially V. album L. The effect of oral and subcutaneous application of fresh V. album L. extracts on blood pressure has been studied in various models; while the data suggests that mistletoe may be a promising herbal extract with cardioprotective properties, the species has only been tested in vitro and in vivo, on animals. In addition, it is unclear whether the cardioprotective activity of mistletoe may be due to particular chemical components, as the chemical composition of mistletoe extracts can vary depending on inter alia the time of harvest, extraction method and plant part. Hence, this activity may instead result from synergistic interactions between various secondary metabolites. Therefore, further studies are needed to identify the mechanisms of action of mistletoe compounds on CVDs, and determine their interactions with other cardioprotective drugs, their metabolic mechanisms, pharamacokinetics and adverse effects. More research is also needed to determine the therapeutic doses of active ingredients for use in clinical trials; this would require an accurate understanding of the chemical composition of extracts from different species of mistletoe (not only V. album L.) and from various host trees.

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Section: Cardioprotective Action Of Mistletoe and Mechamisms Of Actio...mentioning

confidence: 99%

The cardioprotective potential of selected species of mistletoe

Olas

2024

Front. Pharmacol.

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“…This species is present in several Asiatic countries, i.e., China and India, where it is utilized in traditional medicines to treat many ailments, i.e., pains, neuropharmacological disorders, and cancers. The analyses revealed relevant antioxidant and anti-inflammatory activities, which were assigned to polyphenolics and flavonoid constituents [ 100 ]. Another Indian mistletoe corresponds to Dendrophthoe falcata (L.f.) Ettingsh (syn.…”

Section: The Asian Mistletoesmentioning

confidence: 99%

The Antioxidant Activity of Mistletoes (Viscum album and Other Species)

Nicoletti

2023

Plants

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In addition to the European mistletoe, Viscum album, which is the most known and utilized one, there are several species commonly known as mistletoe. They are spread in various regions of the planet and are all characterized by hemiparasitism and epiphytic behaviour. The published studies evidence other similarities, including the sharing of important biological properties, with the common presence of antioxidant effects. However, whereas the European mistletoe is largely utilized in medical treatments, although with controversial aspects, the scientific knowledge and medical uses of other mistletoes are still insufficient. This review focuses on the controversial medical story of European mistletoe regarding its antioxidant activity and the potentiality of the other species named mistletoe pertaining to botanical families and genera different from Viscum.

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“…ABTS˙+ is a metastable radical that can exist in solution for quite a long time; when various antiradical agents are introduced into the medium, a rapid reduction of the radical is observed. The antiradical agent used as a standard was Trolox [13], the antioxidant activity of which was taken as 100%. The reaction was monitored spectrophotometrically at λ = 734 nm: ABTS˙+-radical (blue staining of the solution) is converted to its colourless neutral form upon reduction.…”

Section: Enzyme Preparationsmentioning

confidence: 99%

Bioactive peptides of amaranth: isolation and determination of antioxidant and hypocholesterolemic properties

Mescheryakova,

Sviridova,

Anokhina

et al. 2023

E3S Web of Conf.

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Hydrolysis of the amaranth protein isolate (Amaranthus hypochondriacus L., Voronezh variety) protein isolate by trypsin, papain and alkalase was carried out in order to obtain biologically active peptides with antioxidant and hypocholesterolemic activities. A high degree of protein hydrolysis was shown by trypsin during the first two hours, papain between three and four hours, and alkalase after four hours of hydrolysis. The rate of cleaved protein increased from the first two hours of hydrolysis from 40%, 30% and 15% to 78%, 70% and 60% when trypsin, papain, alkalase were applied, respectively. Maximum hydrolysis of the amaranth protein was observed after 6 h of proteolysis by all enzyme preparations. The molecular weights of the hydrolysis products of the amaranth protein after 2, 4 and 6 h of hydrolysis were determined. All hydrolysates showed a high content of polypeptides with molecular masses of 33 kDa, 18-23 kDa, 52-54 kDa, 40-54 kDa, 6.5-15 kDa. Short-chain peptides with molecular masses of 624 to 2817 Da were detected in the hydrolysates after 6 h of proteolysis. It was determined by capillary electrophoresis method that all protein hydrolysates after 6 h of hydrolysis contain amino acids (tyrosine, phenylalanine, alanine, leucine, valine, proline, alanine) responsible for antioxidant activity of peptides in the studied hydrolysates. The antioxidant activity of peptides in all hydrolysates of amaranth protein isolate was determined by ABTS cation radical reduction method for 6 min. Hypocholesterolemic activity of peptides was shown in protein hydrolysates by trypsin and papain.

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Viscum monoicum: A New Source of Polyphenolic Compounds Responsible for Antioxidant and Anti-Inflammatory Activities

Cited by 4 publications

References 30 publications

The cardioprotective potential of selected species of mistletoe

The cardioprotective potential of selected species of mistletoe

The Antioxidant Activity of Mistletoes (Viscum album and Other Species)

Bioactive peptides of amaranth: isolation and determination of antioxidant and hypocholesterolemic properties

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