<i>Williamsia muralis</i>Pulmonary Infection

Tomás, María; Moure, Raquel; Nieto, Juan Antonio; Fojón, S.; Fernández, Ana; Díaz, María Isabel Ursúa; Villanueva, Rosa; Bou, Germán

doi:10.3201/eid1108.050439

Cited by 17 publications

(11 citation statements)

References 6 publications

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“…According to reports, Williamsia deligens , W. muralis and W. serinedens have been isolated from immunocompromised patients with diabetes mellitus, as well as elderly patients. The most commonly reported sources of Williamsia infection include pulmonary infection [5] , bacteraemia [4] , endophthalmitis [3] and perinatal sepsis [6] . In addition, evidence indicates that Williamsia serinedens is able to grow in oil-contaminated soil; this bacterium is likely to be effective in the biodegradation process and in the decomposition of industrial pollution from soil [7] .…”

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confidence: 99%

“…Adsorption of acetate, 2,3-butandiol, citrate, mannitol, paraffin, sorbitol, trehalose, adonitol, adipate, isoamyl alcohol, l -arabinose, cellobiose, meso-erythritol, m-hydroxybenzoate, p-hydroxybenzoate, myo-inositol, lactate, melezitose, 1,2-propandiol and carbohydrates as carbon sources are usually labor intensive and time consuming. Further, many reports of Williamsia infection are usually misdiagnosed as Rhodococcus and other actinomycete infections; thus, analyzing whole fatty-acid cell walls via molecular methods (such as DNA hybridization techniques and 16S rRNA gene sequencing) is a rapid, accurate and reliable method for identifying actinomycete infections, especially Williamsia infection [2] , [4] , [5] , [8] .…”

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confidence: 99%

“…Williamsia spp. are resistant to ampicillin, oxacillin, erythromycin and trimethoprim/sulfamethoxazole but susceptible to amoxicillin/clavulanate, cefotaxime, imipenem, ciprofloxacin, tobramycin, gentamicin, cotrimoxazole, amikacin, linezolid, meropenem, penicillin G and vancomycin [5] , [6] .…”

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Williamsia spp. are emerging opportunistic bacteria

Keikha

2018

New Microbes and New Infections

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Williamsia spp. are emerging opportunistic bacteria

Keikha

2018

New Microbes and New Infections

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“…Two cases have been reported in the literature in which Williamsia species have been implicated as true pathogens: one case of respiratory tract infection and one case of endophthalmitis, both of which were caused by W. muralis (1,6). Although W. deligens has been isolated from human blood, no infections have been reported (11).…”

Section: Downloaded Frommentioning

confidence: 99%

Perinatal Sepsis Caused by Williamsia serinedens Infection in a 31-Year-Old Pregnant Woman

Yassin¹,

Lombardi²,

Fortunato³

et al. 2010

J Clin Microbiol

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Williamsia serinedens has been isolated from soil but has not yet been implicated in human disease. We report the first case of perinatal sepsis caused by a dual-morphotype form of Williamsia serinedens in a 31-year-old pregnant woman hospitalized with preterm labor. CASE REPORTA 31-year-old woman who was 23 weeks pregnant was admitted to our hospital for management of preterm labor in the setting of cervical insufficiency and twin gestation. She had originally presented to her obstetrician 1 week earlier for routine prenatal care, at which time she was found to have cervical dilation at 5 cm. At the time of admission, the patient was asymptomatic with normal vital signs and unremarkable physical examination. Pelvic ultrasonography revealed a shortened cervix and twin fetuses with normal heart tones, motion, and size. The patient was started on tocolytic therapy utilizing indomethacin and magnesium sulfate, as well as ceftazidime for empirical management of chorioamnionitis.Eight weeks into her hospitalization, the patient reported generalized myalgias and malaise, although no fever was documented initially. After routine hematology revealed a leukocyte (WBC) count of 9,900 WBCs/mm 3 with 34% band forms, an amniocentesis was performed, revealing only 22 WBCs/ mm 3 (reference range, Ͻ30 WBCs/mm 3 ) with culture yielding no growth. Empirical meropenem was initiated, and two sets of blood cultures collected 25 h apart, one from her percutaneously inserted central catheter (PICC) and the other from venipuncture, yielded aerobic, Gram-positive bacilli which could not be identified by our laboratory. The patient's antibiotic therapy was then changed to ampicillin and vancomycin, her PICC line was removed, and the tip was cultured, yielding no growth.Despite empirical therapy, the patient's clinical course worsened with the development of headache, fever, hypotension, and persistence of left shift. After a lumbar puncture revealed only 1 WBC/mm 3 (reference range, Ͻ4 WBC/mm 3 ), cesarean delivery was performed at 32 weeks gestation with successful delivery of twins. The twins had identical Apgar scores of 7 and 9. Placental pathology revealed mild villous edema but no structural anomaly or inflammation. The patient improved thereafter with resolution of fever and sterilization of blood cultures. She completed a 2-week course of intravenous vancomycin and oral ampicillin. Blood cultures collected from each of her neonates on the day of delivery yielded no growth. As of this submission, both she and her infants have recovered and are healthy.The isolate was transferred from our laboratory to the Tennessee Department of Health laboratory, where it was identified as an aerobic actinomycete. Morphologically, it was observed as a pleomorphic Gram-positive, non-acid-fast coccobacillus, whose macrocolonies on brain heart infusion (BHI) agar at 4 to 7 days growth were orange, of soft texture, and with mycelial edges. It was submitted to the Centers for Disease Control and Prevention actinomycete reference laboratory, where it w...

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“…Further this genus has been linked with the degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine in soils as a sole nitrogen source [ 13 ], the degradation of carbonyl sulfide in soils [ 14 ] and polychlorinated biphenyls in tree habitats [ 15 ]. Williamsia was isolated from various sources, including indoor building material [ 1 ], human blood [ 5 ] and following pulmonary infections [ 16 ], oil-contaminated and Antarctic soils [ 4 , 11 ], extreme environments as glacier ice [ 17 ], deep sea sediments of the Mariana Trench [ 8 ], hay meadows [ 6 ], and the rare soil biosphere [ 18 ]. Besides, Williamsia was also reported as an endophyte of grey box eucalyptus tree roots [ 19 ] and as an epiphytic bacterium residing in the phyllosphere of white clover [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Draft genome of the Arabidopsis thaliana phyllosphere bacterium, Williamsia sp. ARP1

Horn¹,

Keller²,

Hildebrandt³

et al. 2016

Stand in Genomic Sci

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The Gram-positive actinomycete Williamsia sp. ARP1 was originally isolated from the Arabidopsis thaliana phyllosphere. Here we describe the general physiological features of this microorganism together with the draft genome sequence and annotation. The 4,745,080 bp long genome contains 4434 protein-coding genes and 70 RNA genes. To our knowledge, this is only the second reported genome from the genus Williamsia and the first sequenced strain from the phyllosphere. The presented genomic information is interpreted in the context of an adaptation to the phyllosphere habitat.Electronic supplementary materialThe online version of this article (doi:10.1186/s40793-015-0122-x) contains supplementary material, which is available to authorized users.

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Williamsia muralisPulmonary Infection

Cited by 17 publications

References 6 publications

Williamsia spp. are emerging opportunistic bacteria

Williamsia spp. are emerging opportunistic bacteria

Perinatal Sepsis Caused by Williamsia serinedens Infection in a 31-Year-Old Pregnant Woman

Draft genome of the Arabidopsis thaliana phyllosphere bacterium, Williamsia sp. ARP1

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