<i>Wolbachia</i>
            small noncoding RNAs and their role in cross-kingdom communications

Mayoral, Jaime G.; Hussain, Mazhar; Joubert, Albert; Iturbe‐Ormaetxe, Iñaki; O'Neill, Scott Leslie; Asgari, Sassan

doi:10.1073/pnas.1420131112

Cited by 76 publications

(61 citation statements)

References 26 publications

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“…Prokaryotes do not have RNAi machinery, they produce small non-coding RNAs that are 70-200 nt in length. In fact, in the endosymbiotic host-bacteria interactions, two bacterial small non-coding RNA WsnRNA-46 and WsnRNA-49 from Wolbachia , a symbiotic bacterium infects many arthropod species, can regulate the target genes from the mosquitoes host Aedes aegypti in addition to its own genes [48]. …”

Section: Cross-kingdom Srna Trafficking From Pathogens and Parasites mentioning

confidence: 99%

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Wang

Thomas

Jin

2017

Current Opinion in Plant Biology

104

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Small RNA (sRNA)-induced RNA interference (RNAi) is an important conserved mechanism that modulates gene expression in almost all eukaryotes. Some sRNAs move short distances from cell to cell, while some travel long distances to spread systemically throughout the organism. Recent studies indicate that sRNAs can even move between organisms to induce gene silencing, a phenomenon called “cross-kingdom RNAi”. sRNA trafficking between a pathogen, pest, or symbiont and its respective host can have a significant impact on interaction compatibility. Certain sRNAs were found to travel from pathogens or pests into host cells and suppress host immunity to achieve successful infection in both plants and animals; while sRNAs generated from host cells also translocate into pathogen or parasite cells to inhibit their virulence. Such cross-kingdom RNAi mechanisms enable the development of efficient disease control methods using plant-derived RNAs that target essential genes of pathogens and pests. Moreover, uptake of exogenous RNAs from the environment was recently discovered in certain fungal pathogens, which makes it possible to suppress fungal diseases by directly applying pathogen–targeting RNAs on crops and post-harvested products to avoid extensive chemical treatment and circumvent generating genetically modified plants. This spray-induced gene silencing (SIGS) strategy is environmentally sustainable and friendly, and can be easily adapted to control multiple fungal diseases simultaneously.

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Section: Cross-kingdom Srna Trafficking From Pathogens and Parasites mentioning

confidence: 99%

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Wang

Thomas

Jin

2017

Current Opinion in Plant Biology

104

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“…One study suggests that pathogenic bacteria might usurp control of host gene expression by broadly suppressing RNA polymerase II, an enzyme required for synthesis of coding and noncoding RNAs (Lutay et al, 2013). Intriguingly, there has been recent evidence that some endosymbiotic bacteria produce small noncoding RNAs with the potential to exert cross-kingdom communication and affect host processes (Mayoral et al, 2014). There are presumably more such examples awaiting discovery, especially in commensal gut and other organ microbes, which have so closely evolved and adapted to their host environments.…”

Section: Potential Mechanism Microbiota Alterations Lead To Asd and Rmentioning

confidence: 99%

Microbiome Disturbances and Autism Spectrum Disorders

2015

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Autism spectrum disorders (ASDs) are considered a heterogenous set of neurobehavioral diseases, with the rates of diagnosis dramatically increasing in the past few decades. As genetics alone does not explain the underlying cause in many cases, attention has turned to environmental factors as potential etiological agents. Gastrointestinal disorders are a common comorbidity in ASD patients. It was thus hypothesized that a gut-brain link may account for some autistic cases. With the characterization of the human microbiome, this concept has been expanded to include the microbiota-gut-brain axis. There are mounting reports in animal models and human epidemiologic studies linking disruptive alterations in the gut microbiota or dysbiosis and ASD symptomology. In this review, we will explore the current evidence that gut dysbiosis in animal models and ASD patients correlates with disease risk and severity. The studies to date have surveyed how gut microbiome changes may affect these neurobehavioral disorders. However, we harbor other microbiomes in the body that might impact brain function. We will consider microbial colonies residing in the oral cavity, vagina, and the most recently discovered one in the placenta. Based on the premise that gut microbiota alterations may be causative agents in ASD, several therapeutic options have been tested, such as diet modulations, prebiotics, probiotics, synbiotics, postbiotics, antibiotics, fecal transplantation, and activated charcoal. The potential benefits of these therapies will be considered. Finally, the possible mechanisms by which changes in the gut bacterial communities may result in ASD and related neurobehavioral disorders will be examined.

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“…We investigated the small RNA profiles of CFAV vsiRNAs in Aag2 and aag2. wMelPop-CLA cells using deep sequencing data produced previously from the cytoplasmic and nuclear fractions of the cells accessible through GEO series accession number GSE55210 (Mayoral et al, 2014b). Small RNA reads were mapped to the CFAV genome (accession no.…”

mentioning

confidence: 99%

Wolbachia suppresses cell fusing agent virus in mosquito cells

Zhang

Etebari

Asgari

2016

Journal of General Virology

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The genus Flavivirus contains a large number of positive-sense ssRNA viruses. While some are transmitted by mosquitoes or other arthropods and are pathogenic to humans and animals (e.g. dengue and Zika viruses), some are insect-specific and do not replicate in vertebrate cells. These are known as insect-specific flaviviruses (ISFs). Cell fusing agent virus (CFAV) was the first described ISF, which was detected in an Aedes aegypti cell line, Aag2. Here, we investigated the effect of Wolbachia, a widespread endosymbiont of many insect species, that is known to block replication of several pathogenic flaviviruses, on CFAV. Our results demonstrated that, in mosquito cells, Wolbachia vastly suppresses replication of CFAV, with significantly less CFAV viral interfering small RNAs produced in the cells. However, removal of Wolbachia with tetracycline led to increased CFAV replication. These results suggest that Wolbachia is also able to suppress an ISF.

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Wolbachia small noncoding RNAs and their role in cross-kingdom communications

Cited by 76 publications

References 26 publications

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Microbiome Disturbances and Autism Spectrum Disorders

Wolbachia suppresses cell fusing agent virus in mosquito cells

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