2024
DOI: 10.1101/2024.05.15.594175
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XistDeletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes

Claudia D. Lovell,
Nikhil Jiwrajka,
Hayley K. Amerman
et al.

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease preferentially observed in females. X-linked gene expression in XX females is normalized to that of XY males by X-Chromosome Inactivation (XCI). However, B cells from female SLE patients and mouse models of SLE exhibit mislocalization of Xist RNA, a critical regulator of XCI, and aberrant expression of X-linked genes, suggesting that impairment of XCI may contribute to disease. Here, we find that a subset of female mice harboring a conditional deletio… Show more

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