<i>Yerba mate (Ilex paraguariensis)</i> favors survival and growth of dopaminergic neurons in culture

Bernardi, Maria A. De; Ballestero, Pedro; Schenk, Marcela; Ferrario, Mariana Inés; Gómez, Gimena; Rivero, Roy; Avale, Elena M.; Taravini, Irene Rita Eloisa; Gershanik, Oscar S.; Guerrero, Sandra; Ferrario, Juan E.

doi:10.1002/mds.27667

Cited by 14 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, a study by Bernardi et al showed that Yerba Mate extracts prevented dopaminergic death by exhibiting a strong dose-dependent neuroprotective effect on primary midbrain cultures, which may be important for preventing progression of Parkinson's disease. Chlorogenic acid and theobromine tested individually also had neuroprotective effects, but slightly weaker than Yerba Mate extract as a whole, but stronger than known neuroprotective compounds, such as caffeine [83].…”

Section: Other Effectsmentioning

confidence: 84%

Yerba Mate—A Long but Current History

2021

View full text Add to dashboard Cite

Bearing in mind the growing interest in Yerba Mate, a comprehensive study has been prepared containing the most important aspects and possibilities of its use. The introduction of the work contains the species characteristics of Yerba Mate, as well as information about the origin and places of cultivation. The next part focuses on the analysis of the composition, pointing to purine alkaloids, polyphenols, saponins, and minerals as groups of active compounds responsible for the clinical activity of Yerba Mate. The review of the results of preclinical and clinical studies indicates activity in relation to the stimulating effect, reducing weight by stimulating lipolysis, cardioprotective, anti-diabetic, and anti-inflammatory effects. The information about the action of Yerba Mate is supplemented by the characteristics of its potential toxicity in terms of PAHs content (in particular benzo[α]pyrene) and preparation as a determinant of increased irritation. The current data on the effects of Yerba Mate and the wide safety margin of its use position this raw material as a valuable component of functional food. The growing frequency of consuming Yerba Mate, conditioned by the availability resulting from the globalization of the market and the information provided about it’s the pro-health effects, will position Yerba Mate's popularity among wider population groups.

show abstract

Section: Other Effectsmentioning

confidence: 84%

Yerba Mate—A Long but Current History

2021

View full text Add to dashboard Cite

show abstract

“…More recently, Bernardi et al (10) showed that IP has protective effects on dopaminergic neurons, preventing neuronal death in cell culture (10). Our study did not evaluate IP composition and the concentration of caffeine and antioxidants, but both mechanisms should be considered.…”

Section: Discussionmentioning

confidence: 85%

“…Previous studies have demonstrated a high content of antioxidants and substances with iron chelation properties in IP, which could elicit a potential protective effect on PD (8,9). In a recent study by Bernardi et al (10), they demonstrated that IP may have a strong neuroprotective activity on dopaminergic neurons, preventing their death with a dosedependent effect (10).…”

Section: Introductionmentioning

confidence: 99%

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

et al. 2021

View full text Add to dashboard Cite

Introduction: Coffee has been inversely associated with Parkinson's disease (PD) in many studies, and caffeine is the leading candidate to mediate this effect. Mate (Ilex paraguariensis, IP), a caffeinated beverage rich in antioxidants consumed in South America, was also inversely associated with PD in one study from Argentina. Other varieties of IP infusion, such as chimarrão, were never studied in PD. Chimarrão is a common caffeinated beverage consumed in Brazil made with the leaves and stems of IP.Methods: A case–control study was conducted to evaluate the relationship between chimarrão ingestion and PD in southern Brazil. All subjects answered a questionnaire about the frequency of chimarrão and coffee intake. A multiple regression analysis adjusted for age and sex was performed to assess the association between PD and chimarrão consumption.Results: We included 200 PD patients and 200 healthy controls. High consumption of chimarrão was inversely associated with PD (OR = 0.44, 95% CI = 0.24–0.81, P = 0.008). High consumption of coffee was also inversely associated with PD, as expected. Chimarrão remained associated when adjusted for coffee consumption, smoking history, and age (OR 0.46, 95% CI = 0.25–0.86, P = 0.014). These two exposures showed an additive effect.Conclusion:Chimarrão consumption was inversely associated with PD, even after adjusting for coffee intake, suggesting a possible protective role. IP's effect can be mediated by caffeine and through its antioxidant components. Chimarrão has a lower concentration of caffeine compared with coffee and has numerous substances with antioxidative effects that may be important to PD protection. Further studies are needed to test this hypothesis.

show abstract

“…A neurodegeneration model tested in culture showed the protective effect of the YMT on dopaminergic neurons; 2 of its major compounds, chlorogenic acid and theobromine, even registered a stronger neuroprotective influence than the antioxidant Trolox. The authors also observed a pronounced increase in axonal length and branching of dopaminergic neurons treated with YMT than the control group 23 . The neuroprotective properties of YMT have been proposed for other neurodegenerative diseases such as Alzheimer 24 and amyotrophic lateral sclerosis 25 .…”

Section: Discussionmentioning

confidence: 87%

Yerbamate Tea Consumption: A Protective Factor in Parkinson Disease

et al. 2022

View full text Add to dashboard Cite

IntroductionLittle is known about the association between Yerbamate (YMT) tea consumption and Parkinson disease (PD). We determined whether there was an association between YMT tea consumption and PD.MethodsWe conducted a multicenter case-control study in 3 countries (Argentina, Paraguay, and Uruguay). We applied a structured questionnaire about YMT tea consumption history. The survey also included information about factors previously associated with a decreased and increased risk of PD, apart from medical and demographic factors. Odds ratios and 95% confidence intervals were calculated using multivariate unconditional binary logistic regression analysis.ResultsWe included 215 cases and 219 controls. The mean age of the cases was 65.6 ± 10.5 years and that of controls was 63.1 ± 10.5 years (P < 0.02). Years of YMT tea consumption, number of liters drunk per day, and amount of YMT used for preparing the infusion were similar between cases and controls (P > 0.05), but not the number of times the YMT was added into the container (P = 0.003) and the YMT tea concentration per serving (P = 0.02). The multivariate analysis showed that YMT tea concentration per serving lowered the risk for PD, independent of potential confounders (odds ratio, 0.62; 95% confidence interval, 0.47–0.84).ConclusionsThis multicenter study highlights the association between an environmental factor, the YMT tea drinking, and PD. Although more evidence from longitudinal studies is needed, the results obtained here points toward a protective effect of the YMT tea concentration per serving on PD.

show abstract

Yerba mate (Ilex paraguariensis) favors survival and growth of dopaminergic neurons in culture

Cited by 14 publications

References 7 publications

Yerba Mate—A Long but Current History

Yerba Mate—A Long but Current History

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

Yerbamate Tea Consumption: A Protective Factor in Parkinson Disease

Contact Info

Product

Resources

About