<i>Yersinia enterocolitica</i>
            infection in children

Marriott, Deborah; Taylor, S L; Dorman, David C.

doi:10.5694/j.1326-5377.1985.tb119908.x

Cited by 15 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yersiniosis ranges from self-limited enteritis to life-threatening systemic infections. The most frequent manifestation is diarrhea, mainly affecting children [4] , [10] – [14] . Although antibiotic treatment is recommended for serious cases, the benefits of antibiotic therapy in uncomplicated cases is not well established [5] , [15] – [17] .…”

Section: Introductionmentioning

confidence: 99%

Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible

et al. 2013

View full text Add to dashboard Cite

Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY.

show abstract

Section: Introductionmentioning

confidence: 99%

Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Children infected with Yersinia enterocolitica also develop symptoms fulfilling the diagnostic criteria for KD in Europe, Australia (3%; one out of 32 patients), the United States and Japan (our observation; 10%: two out of 20 patients). 43,44 Most patients show abdominal symptoms and incomplete KD symptoms (five of six patients) without coronary artery lesions. 43,44 In summary, subsets of patients with Y. pseudotuberculosis and Y. enterocolitica infections also develop symptoms fulfilling the diagnostic criteria for KD.…”

Section: Involvement Of Microbes Pamps and Damps In Kdmentioning

confidence: 99%

“…43,44 Most patients show abdominal symptoms and incomplete KD symptoms (five of six patients) without coronary artery lesions. 43,44 In summary, subsets of patients with Y. pseudotuberculosis and Y. enterocolitica infections also develop symptoms fulfilling the diagnostic criteria for KD. The incidence of Yersinia infection-associated development of KD symptoms varies with the geographical regions.…”

Section: Involvement Of Microbes Pamps and Damps In Kdmentioning

confidence: 99%

The up‐to‐date pathophysiology of Kawasaki disease

2021

View full text Add to dashboard Cite

Kawasaki disease (KD) is an acute systemic vasculitis of an unknown aetiology. A small proportion of children exposed to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) or infected by Yersinia reproducibly develop principal symptoms of KD in various ethnic areas, but not in all studies. These microbes provoke a rapid cell‐damaging process, called ‘pyroptosis’, which is characterised by a subsequent release of proinflammatory cellular components from damaged endothelial and innate immune cells. In agreement with these molecular events, patients with KD show elevated levels of damage‐associated molecular patterns derived from cell death. In addition, an overwhelming amount of oxidative stress‐associated molecules, including oxidised phospholipids or low‐density lipoproteins, are generated as by‐products of inflammation during the acute phase of the disease. These molecules induce abnormalities in the acquired immune system and activate innate immune and vascular cells to produce a range of proinflammatory molecules such as cytokines, chemokines, proteases and reactive oxygen species. These responses further recruit immune cells to the arterial wall, wherein inflammation and oxidative stress closely interact and mutually amplify each other. The inflammasome, a key component of the innate immune system, plays an essential role in the development of vasculitis in KD. Thus, innate immune memory, or ‘trained immunity’, may promote vasculitis in KD. Hence, this review will be helpful in understanding the pathophysiologic pathways leading to the development of principal KD symptoms and coronary artery lesions in patients with KD, as well as in subsets of patients with SARS‐CoV‐2 and Yersinia infections.

show abstract

“…Über die im Kindesalter charakteristischen Manifestationsformen sowie deren Symptomatik herrscht Überein-stimmung [1,8,17,19]. Am häufigsten tritt eine Yersiniainfektion bei Säuglin-gen sowie Kleinkindern als akute fieberhafte, oft mit blutigen Stühlen einhergehende, meist selbstlimitierende Durchfallerkrankung auf.…”

Section: Diskussionunclassified