(Z)-1-[2-(Trifluoromethyl)benzylidene]thiosemicarbazide

Abstract

In the crystal structure of the title compound, C9H8F3N3S, all atoms except for two of the F atoms are located on a mirror plane. In the crystal, the molecules are connected by N—H⋯S hydrogen bonds, forming a mol­ecular tape along the a axis.

Crystal Structure of (<i>Z</i>)-1-[4-(Trifluoromethyl)benzylidene]thiosemicarbazide

“…This is slightly shorter compared with C=N (1.279(3)Å) in the other isomer. 6 Meanwhile, the bond angles for C8A-N1A-N2A and C8B-N1B-N2B are 115.21(17) and 116.49(17) , respectively, and have no significant differences with another reported isomer, which has a bond angle of 116.0(2) . 6 Other bond lengths and angles are in the normal ranges.…”

“…6 Meanwhile, the bond angles for C8A-N1A-N2A and C8B-N1B-N2B are 115.21(17) and 116.49(17) , respectively, and have no significant differences with another reported isomer, which has a bond angle of 116.0(2) . 6 Other bond lengths and angles are in the normal ranges. 8 This study reveals that the position of the trifluoromethyl group at either ortho or para of phenyl does not have any significant effects towards the bond length and angles of the C=N-N moiety.…”

“…Previously, the crystal structure of the isomer (Z)-1-[2-(trifluoromethyl)-benzylidene]thiosemicarbazide had already been published. 6 However, the present crystal structure of (Z)-1-[4-(trifluoromethyl)-benzylidene]thiosemicarbazide (1) was yet reported. Thus, our present report is to contribute deeper understanding about the crystal structure of (1).…”

“…The introduction of trifluoromethyl at the para position of benzyl forbids the formation of intramolecular hydrogen bonds, as similarly observed in the case of (Z)-1-[2-(trifluoromethyl)benzylidene]thiosemicarbazide. 6 In the crystal structure of 1, each of molecule is linked by four intermolecular hydrogen bonds, namely N2A-H1NA···S1A, N3A-H3NA···S1B, N3B-H3NB···S1A and N2B-H1NB···S1B (symmetry codes as in Table 3) to form a one-dimensional wave-like chain parallel to (032) plane (Fig. 2).…”

Synthesis of Arylidenehydrazinyl‐4‐methoxyphenylthiazole Derivatives: Docking Studies, Probing Type II Diabetes Complication Management Agents

“…The compounds 2-(2-arylidenehydrazinyl)-4-(4-methoxyphenyl)thiazoles (3a-o) were prepared by heating an equimolar mixture of respective thiosemicarbazones [24][25][26][27][28][29][30][31][32][33] and 2-bromo-4-methoxy acetophenone in absolute ethanol as shown in Scheme 1. [34 -36] The cyclized products were achieved in moderate to good yield (67-79 %).…”