Zingiber officinaleextract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: anin vitrostudy

Abstract

The antidiabetic effect of ginger was experimentally proved in the study and has concluded that the activity is initiated by antioxidant, antiglycation and potential to express or transport Glut4 receptors from internal vesicles.

Dietary Ginger Extracts Enhanced Glucose Uptake by Muscle and Adipose of Normal and Diabetic Rats via Mimicry of Insulin Action

“…The ability of [6]-gingerol to regulate the gene expression of enzymes related to glucose metabolism towards decreasing gluconeogenesis and glycogenolysis as reported by which is a similar function of insulin as earlier explained may further ascertain the mimicry of insulin function by ginger. The enhancement of glucose uptake by myotubes of muscles by ethyl acetate ginger extract and gingerol was also observed by Rani et al, [26] and Son et al, [3] in vitro as well as in vivo in obese diabetic mice (3). This marked increase in glucose uptake may be the induction of 5'adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in L6 myotubes and the promotion of glucose transporter 4 (GLUT 4) translocation to cell membrane by [6]-gingerol and ethyl acetate ginger extract [3,26].…”

“…On the other hand 5' adenosine monophosphate-activated protein kinase (AMPK), regarded as cellular energy sensor, has been reported to promote GLUT4 translocation independently of insulin [25]. Ethyl acetate ginger extract was observed to enhance glucose uptake in cell lines in mice by expressing GLUT4 in cell surface [26]. While [6]-gingerol also exerted similar effect via this mechanism as well as via induction or enhancement of AMPK phosphorylation in L6 myotubes [3].…”

An Overview: Ginger, a Tremendous Herb

“…Abdulrazaq et al (2011) was described that the effect of long term administration of ginger in the type-1 diabetic rats reduces the blood glucose level total cholesterol, triglycerides, enhance the insulin levels and prevent the animals from body weight kidney and liver weight losses. The ethyl acetate extract of ginger decrease lipid content in 3T3 adipocyte, inhibited proteinglycation and encourage the glucose uptake and GLUT4 expression in L6 myotube cell surface (Noipha et al, 2010;Rani et al, 2012). Most of the studies have proven 6-gingerol a main bioactive moiety of ginger which contributes in controlling the metabolic syndromes.…”

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“…Activity is initiated by antioxidant, antiglycation and potential to express or transport Glut4 receptors from internal vesicles. 53 Polyphenol extracts of Zingiber officinale rhizome investigated for antidiabetic potential in pancreatic and renal tissues of diabetic rats at a dose of 500 mg/kg body weight. Reviled in histological examination of pancreas and kidney restoration of the structural derangements caused by streptozotocin in the polyphenol extracts treated diabetic rats compared to the control groups.…”