<i>α</i>-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus

Aitken, Juan Pablo; Ortiz, Carolina; Morales-Bozo, Irene; Alcayaga, Gonzalo Rojas; Baeza, Mauricio; Beltrán, Caroll J.; Escobar, Alejandro

doi:10.1155/2015/128653

Cited by 42 publications

(42 citation statements)

References 23 publications

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“…A positive correlation was found between α-2-macroglobulin and HbA1c, which demonstrated that levels of α-2-macroglobulin in the saliva could reflect the glycaemic control in patients with type 2 diabetes mellitus. 25 However, the concentration of salivary melatonin decreased in patients with type 2 diabetes and patients with periodontitis. This indicates that salivary melatonin has an important role in the pathogenesis of diabetes and periodontal diseases, and might become a key biomarker in the diagnosis and treatment of these two diseases.…”

Section: Diagnosis Of Systematic Diseases By Salivamentioning

confidence: 99%

Saliva in the diagnosis of diseases

et al. 2016

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Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.

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Section: Diagnosis Of Systematic Diseases By Salivamentioning

confidence: 99%

Saliva in the diagnosis of diseases

et al. 2016

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“…It was showed by a proteomic evaluation that cell motility proteins-involved were up or down expressed in saliva from patients with DM versus controls (18). Higher levels of potassium and human α2-macroglobulin and lower expression of s-IgA and EGF secretion rates were also observed in diabetics when compared to healthy subjects by ELISA (19,20). It also has been demonstrated that animals diabetes-induced have important changes in the production of a several different extracellular matrix components and growth factors as TGFβ isoforms for example (8,21).…”

Section: Tgfβ1 In Diabetic and Hypertensive Patientsmentioning

confidence: 99%

Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

et al. 2018

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in this cross-sectional study, whole stimulated saliva and oral mucosa exfoliative cytology specimens were collected from 39 patients that were healthy (control, n=10) or presented history of arterial hypertension (HAS, n=9), diabetes mellitus (DM, n=10) or both (DM+HAS, n=10). Salivary flow rate (SFR), TGFβ1 level in saliva, AgNORs and the epithelial maturation were evaluated. Non-parametric Kruskal-Wallis test, followed by Dunn's multiple comparison post-test and the Spearman test correlation analysis were used. SFR showed a significant decreased in DM and DM+HAS (0.47±0.11 and 0.64±0.43 mL/min) when compared to control (1.4±0.38 mL/min). DM+HAS presented the highest value of TGFβ1 concentration (24.72±5.89 pg/mL). It was observed a positive correlation between TGFβ1 and glycaemia (R=0.6371; p<0.001) and a negative correlation between TGFβ1 and saliva (R=-0.6162; p<0.001) and glycaemia and SFR (R=-0.5654; P=0.001). AgNORs number and status of maturation of mucosa cells were similar for all conditions. DM and DM+HAS presented the lowest SFR, which correlated with increased TGFβ1 levels. Despite the higher TGFβ1 secretion it was not observed changes in the morphology or proliferation of epithelial cells when diabetes or hypertension was present.

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“…Diabetes is a metabolic disease caused by lack of insulin secretion, insulin action or insulin resistance, which impairs the body's ability to process blood glucose. A positive association found between α-2-macroglobulin and HbA1c, demonstrated that levels of α-2-macroglobulin in the saliva could reflect the glycaemic control in patients with type 2 diabetes mellitus [30]. Type 1 diabetic hyperglycemia requires measuring exhaled methyl nitrate [31].…”

Section: Diabetesmentioning

confidence: 99%