<i>α</i>-Glucosidase Inhibition Research of Derivatives Based on 2<i>β</i>-Acetoxyferruginol Scaffold Excluding Acetic Acid Group

Wu, Simin; Tang, Jiaxin; Zhou, Yujia; Xu, Xuetao; Zhang, Haoxing; Wang, Shaohua

doi:10.6023/cjoc202307027

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Fluorescence measurements of α-glucosidase were conducted at an excitation wavelength of 280 nm ( Wu et al, 2024 ). Then, honokiol was added step by step, and the corresponding fluorescence of the mixture was recorded.…”

Section: Methodsmentioning

confidence: 99%

Honokiol as an α-glucosidase inhibitor

Zhu,

Zhong

2024

Front. Pharmacol.

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Honokiol, a naturally occurring compound from Magnolia obovata Thunb., has many biological activities, but its anti-α-glucosidase activity is still unclear. Therefore, we determined its inhibitory effects against α-glucosidase. Activity assays showed that honokiol was a reversible mixed-type inhibitor of α-glucosidase, and its IC50 value was 317.11 ± 12.86 μM. Fluorescence results indicated that the binding of honokiol to α-glucosidase caused a reduction in α-glucosidase activity. 3D fluorescence and CD spectra results indicated that the binding of honokiol to α-glucosidase caused conformational change in α-glucosidase. Docking simulated the detailed interactions between honokiol and α-glucosidase, including hydrogen and hydrophobic bonds. All findings showed that honokiol could be used as a natural inhibitor to develop α-glucosidase agents.

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Section: Methodsmentioning

confidence: 99%