Abstract:Motivation:The positional Burrows-Wheeler Transform (PBWT) has been introduced as a key data structure for indexing haplotype sequences with the main purpose of finding maximal haplotype matches inhsequences containingwvariation sites inO(hw)-time with a significant improvement over classical quadratic time approaches. However the original PBWT data structure does not allow queries over the modern biobank panels of haplotypes consisting of several millions of haplotypes, as they must be kept entirely in memory… Show more
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