I405V and TaqIB polymorphisms of the cholesteryl ester transfer protein and their relation to serum lipid and lipoprotein levels in a Turkish population

Abstract

Cholesteryl ester transfer protein (CETP) plays a central role in high-density lipoprotein (HDL) metabolism. Genetic polymorphisms of the CETP gene can influence levels of serum lipoproteins. It has been reported that mean HDL-cholesterol (HDL-C) concentrations are low in Turkish population. Thus, we investigated the frequencies of the common I405V and TaqIB polymorphisms of the CETP gene and their relation to serum lipid and lipoprotein levels in a Turkish population. The variant allele frequencies of I405V and TaqIB polymorphisms of the CETP gene were found to be 0.38 and 0.46, respectively and similar to some of the European populations. Subjects for the VV genotype of I405V polymorphism had higher HDL-C levels than did II subjects. The covariance analysis showed that gender and triglyceride (TG) levels have an effect on the association of HDL-C and I405V polymorphism. In conclusion, our results indicate that I405V polymorphism may affect the HDL-C levels in Turkish population. The association of this polymorphism and HDL-C levels could be modified by other factors, such as gender and TG levels.

Association Between Cholesteryl Ester Transfer Protein TaqIB Variants and Risk of Coronary Artery Disease and Diabetes Mellitus in the Population of Western Iran

“…, 2005). However, in two other studies from Turkey, the TaqIB polymorphism was not associated with HDL-C level or risk of CAD among angiographically documented patients with CAD (Tanrikulu-Kucuk et al, 2010) and was not correlated to HDL-C in healthy individuals (Dogru-Abbasog et al, 2009). Also, Chaaba et al (2005) reported no association between TaqIB polymorphism and CAD in T2DM.…”