I405V polymorphism ofCETPgene and lipid profile in women with endometriosis

Abstract

Genetic factors have an important role in the pathophysiology of endometriosis. In addition, abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP) gene and lipid profile with the risk of endometriosis in women. Ninety-seven women with laparoscopy-diagnosed endometriosis were recruited for this study, and 107 patients with no evidence of endometriosis confirmed by laparoscopy served as controls. Samples were analyzed for polymorphism of the CETP gene using polymerase chain reaction-restriction fragment length polymorphism-based methods. After adjustment for body mass index, high-density lipoprotein-C and low-density lipoprotein-C, the risk of endometriosis in patients with normal genotype homozygous was more of the rare allele (p < 0.001, odds ratio = 0.21, 95% confidence interval = 0.09-0.45). Our results suggest that I405V polymorphism of CETP gene plays an important role as independent factor in the risk of endometriosis in women.

Lack of association between LIPC‐514 C/T polymorphism of hepatic lipase and endometriosis in Iranian women

“…The present study demonstrated that patients with endometriosis had lower BMI and higher HDL‐C than the control group. These observations are consistent with previous studies and have been discussed earlier . In this study, patients with endometriosis had significantly higher levels of TC and LDL‐C than patients without endometriosis, but no significant difference was found for TG, which might be attributed to the lower BMI in the endometriosis group.…”

“…The study was approved by the ethics committee of Qazvin University of Medical Sciences. A total of 97 patients had surgical and histological evidence of endometriosis, while 107 cases without the disease served as controls: uterine myoma (18 cases), dermoid cyst (20 cases), paraovarian cyst (18 cases), serous cyst (15 cases) and healthy women with infertility and/or pelvic pain (36 cases), as previously reported by us . The extent of the disease was staged according to the revised American Fertility Society Classification .…”

Endometriosis — insights into a multifaceted entity

“…Genetic markers belong to variable categories, such as: oxidative stress genes [86], tumor suppressor genes [87][88][89][90][91][92][93][94][95][96][97][98], oncogenes [90,[99][100][101][102][103], regulatory genes [104,105], DNA repair genes [93], chromosomal aberrations or amplifications [106][107][108], loss of heterozygosity [87,107,109], genetic polymorphism of variable genes [107,[110][111][112][113][114][115][116][117][118][119], and genome-wide alterations [120,121].…”

Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

“…Its global prevalence is about %5-10% [2]. This syndrome is characterized by symptoms such as menstrual disorders (especially oligomenorrhea), presence of small cysts in the ovaries on ultrasound images, and the symptoms of hyper-androgenism such as hirsutism, acne, and hair loss [3,4]. Although the exact cause of PCOS is still unknown, genetic factors can play an important role in the development of this disease.…”