IAEA coordinated research programme: nuclear data for the production of therapeutic radionuclides

Abstract

Abstract. The need for radioisotopes in cancer therapy is very well established. With a view to providing standardised data for the production of relevant radioisotopes an IAEA Coordinated Research Project on "Nuclear Data for the Production of Therapeutic Radionuclides" was started in 2003, and is now close to completion. Experimental data compilations, theoretical calculations and evaluations were carried out for each of the reactions. The recommendations for both established and emerging radionuclides are discussed. Examples of the analyses carried out to produce the recommended data for some radionuclides are also presented. The improved quality of the nuclear data will make reactor and accelerator production of therapeutic radionuclides much more efficient and effective, and should also enhance their quality through improved purity.

Bulk production and evaluation of high specific activity 186gRe for cancer therapy using enriched 186WO3 targets in a proton beam

“…The irradiation detailed in this manuscript yielded 186g Re with a total theoretical yield (TTY) that validates the IAEA recommended cross section data [33]. Rhenium-186g was purified from the target material in high radiochemical yield and purity.…”

Charged particle induced reaction cross section data for production of the emerging medically important positron emitter 64Cu: A comprehensive evaluation

“…Out of the seven nuclear reactions evaluated in this work, four processes, namely 64 Ni( p, n) 64 Cu,64 Ni(d, 2n) 64 Cu, 68 Zn( p, αn) 64 Cu and nat Zn(d, x) 64 Cu, are the same as previously evaluated under an IAEA-CRP [16]. For the 64 Ni( p, n) 64 Cu and nat Zn(d, x) 64 Cu reactions, the cross sections and integral yields recommended by the CRP are higher than our recommended values by 5-20% and 6-15%, respectively.…”

“…A recent study on therapeutic radionuclides under the auspices of a Coordinated Research Project (CRP) of the IAEA has also dealt with the evaluation of cross sections of several charged particle induced reactions leading to the formation of 64 Cu in no-carrier-added form ( [16]; see also: Therapeutical radioisotopes production, Table 1. Investigated nuclear reactions for the production of 64 Cu, Q-values and references.…”

Evaluation of charged particle induced reaction cross section data for production of the important therapeutic radionuclide186Re

“…A recent study on therapeutic radionuclides under the auspices of a Co-ordinated Research Project (CRP) of the IAEA [10,11] has also dealt with the evaluation of cross sections of the same reactions leading to the formation of 186 Re in no-carrier-added form. The authors responsible for the evaluation of the production data of 186 Re in the CRP also reported their findings separately [12,13,20].…”