2005
DOI: 10.1038/sj.cdd.4401696
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IAPs – the ubiquitin connection

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Cited by 36 publications
(25 citation statements)
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“…Thus, IAP induction may inhibit apoptosis in several cells [21,31,32]. Because of its ubiquitous distribution and inducible properties, the IAP family serves as cytoprotective machinery under bacterial toxin-stimulated pathophysiological situations [21].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, IAP induction may inhibit apoptosis in several cells [21,31,32]. Because of its ubiquitous distribution and inducible properties, the IAP family serves as cytoprotective machinery under bacterial toxin-stimulated pathophysiological situations [21].…”
Section: Discussionmentioning
confidence: 99%
“…8 This is highlighted by several manuscripts in this issue. [9][10][11][12][13] However, the most striking example of the involvement of the UPS in apoptosis is provided by the fact that some apoptosisrelated proteins contain domains with E3-like activity owing to a unique C-terminal RING domain, as elegantly described by Vaux, and Silke 9 and in the Swiss-German humour of Pascal Meier. 10 These are the inhibitor of apoptosis (IAP) family of proteins, including XIAP, c-IAP-1 and c-IAP-2.…”
mentioning
confidence: 99%
“…IAP-binding motifs can be generated by proteolysis, for example, by caspase cleavage; according to Varshavsky, IAP would be acting as E3 N-recognins for a type-3, primary destabilising alanine residue at the amino-termini of proteins with potential IAPbinding motifs. 9 Inactivation of the proteasome following caspase-mediated cleavage may disable the proteasome, interfering with its role in the regulation of key cellular processes and thereby facilitating an increase in the induction of apoptosis. 14 This concise look at the N-end rule and the RING E3 activity of IAPs shows how understanding of these functions is just taking its first steps.…”
mentioning
confidence: 99%
“…70 The lack of this key feature in cIAP1 and 2 results in a catalytic inhibition that is 100-to 1000-fold less efficient. 69 Nevertheless, cIAP1 and 2, as well as XIAP, may prevent caspase activation by targeting bound caspases for ubiquitinmediated proteasomal degradation, 71 providing an explanation why HtrA2/Omi targets all three IAP members. In marked contrast to its effect on caspases, XIAP binding enhanced the proteolytic activity of HtrA2/Omi.…”
mentioning
confidence: 99%