Iatrathecd morphine for the control of the pain of myocardial infarction

Pasqualucci, V.; Moricca, G; Solinas, Patrizia

doi:10.1111/j.1365-2044.1981.tb08612.x

Cited by 22 publications

(3 citation statements)

References 5 publications

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“…The pain of acute myocardial infarction has been relieved by both intrathecal [143] and extradural morphine [180]. In both instances pain relief was obtained where the i.m.…”

Section: Other Acute Painmentioning

confidence: 99%

The Rational Use of Intrathecal and Extradural Opioids

Morgan

1989

British Journal of Anaesthesia

201

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“…The pain of acute myocardial infarction has been relieved by both intrathecal [143] and extradural morphine [180]. In both instances pain relief was obtained where the i.m.…”

Section: Other Acute Painmentioning

confidence: 99%

The Rational Use of Intrathecal and Extradural Opioids

Morgan

1989

British Journal of Anaesthesia

201

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“…Morphine, a -opioid receptor agonist, has been used clinically for the treatment of acute pulmonary oedema 1 and relief of myocardial infarct pain. 2 In addition, it has been shown to modify cardiac function. In isolated mammalian cardiac tissue, [3][4][5] morphine produces a negative inotropic and chronotropic effect.…”

mentioning

confidence: 99%

Opioid receptor independent effects of morphine on membrane currents in single cardiac myocytes

Hung

Tsai

1998

British Journal of Anaesthesia

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We have examined the effects of morphine, a mu-opioid receptor agonist, on various membrane ionic currents in rat ventricular and human atrial myocytes, using patch-clamp techniques in the whole-cell configuration. Morphine produced a concentration-dependent reduction in peak transient sodium current. When the sodium current (INa) was evoked at 5-s intervals the estimated IC50 for morphine was approximately 30 mumol litre-1. Morphine 10 mumol litre-1 inhibited INa with a 5-mV shift in the potential-dependent inactivation curve to negative potentials and retarded the INa recovery rate from the inactivated state. Use-dependent INa block was not observed when INa was elicited at frequencies varying from 0.2 to 20 Hz. Morphine did not significantly affect the inward calcium current (ICa), transient outward current (Ito) or the inwardly rectifying potassium current (IK1) at a concentration of 30 mumol litre-1. The inhibitory effect of morphine on INa could not be prevented or reversed by treatment with the opioid antagonist naloxone. Therefore, we suggest that morphine can directly inhibit the Na+ inward current and bind to inactivated Na+ channels.

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“…Opiates remain the drug of choice for the management of acute cardiac pain, therefore it seemed appropriate to investigate alternative methods of opiate administration. Previous studies have reported the use of spinal 37 and epidural analgesia 38 post‐MI, although this was confined to small groups of patients in whom conventional drug therapy had not worked. Patient controlled analgesia (PCA) has also been previously reported in a small observational study 39 .…”

Section: Pain Managementmentioning

confidence: 99%

Meeting the Challenge of Acute Pain Management in Coronary Heart Disease

Smith

2002

Progress Cardiovascular Nurs

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Iatrathecd morphine for the control of the pain of myocardial infarction

Cited by 22 publications

References 5 publications

The Rational Use of Intrathecal and Extradural Opioids

The Rational Use of Intrathecal and Extradural Opioids

Opioid receptor independent effects of morphine on membrane currents in single cardiac myocytes

Meeting the Challenge of Acute Pain Management in Coronary Heart Disease

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