2015
DOI: 10.1530/edm-15-0087
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Iatrogenic myxoedema madness following radioactive iodine ablation for Graves' disease, with a concurrent diagnosis of primary hyperaldosteronism

Abstract: SummaryMyxoedema madness was first described as a consequence of severe hypothyroidism in 1949. Most cases were secondary to long-standing untreated primary hypothyroidism. We present the first reported case of iatrogenic myxoedema madness following radioactive iodine ablation for Graves' disease, with a second concurrent diagnosis of primary hyperaldosteronism. A 29-year-old woman presented with severe hypothyroidism, a 1-week history of psychotic behaviour and paranoid delusions 3 months after treatment with… Show more

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Cited by 8 publications
(6 citation statements)
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“…The treatment includes correcting the thyroid imbalance. It was thought to be enhanced via administering intravenous thyroxine or even triiodothyronine [3,14,27,28]. However, many recent cases have shown excellent outcomes utilizing oral thyroxine (T4) [16,21].…”
Section: Discussionmentioning
confidence: 99%
“…The treatment includes correcting the thyroid imbalance. It was thought to be enhanced via administering intravenous thyroxine or even triiodothyronine [3,14,27,28]. However, many recent cases have shown excellent outcomes utilizing oral thyroxine (T4) [16,21].…”
Section: Discussionmentioning
confidence: 99%
“…Myxedema psychosis can respond as quickly as within days to a few weeks to thyroxine replacement 6 12–14 16–18. Some physicians use anti-psychotic treatment for a short period to control the psychosis symptoms at the beginning of the illness; these medications can be safely discontinued on follow-up after ensuring that there is no recurrence of symptoms 17…”
Section: Discussionmentioning
confidence: 99%
“…Only seven case reports with a title suggesting an association between primary hyperaldosteronism and thyrotoxicosis were found [ 29 – 35 ], but of which no abstract was available in three of the articles ( Table 1 ). Larouche et al had described a 29-year-old lady in whom there was coexisting primary hyperaldosteronism due to the fact that IHA and Graves' disease were diagnosed, highlighting that PA may be associated with autoimmune hyperthyroidism [ 32 ]. Anaforoğlu et al describe a 51-year-old lady who presented with hypokalemic paralysis precipitated by coexisting left-sided aldosterone secreting adenoma and toxic nodular goiter [ 33 ], while Yokota et al reported a case of PA due to left-sided adrenal adenoma coexisting with Graves' thyrotoxicosis resulting in hypokalemic paralysis, highlighting rarity of the association and importance of diagnosis [ 34 ].…”
Section: Discussion and Review Of Literaturementioning
confidence: 99%