Iatrogenic pathology of the urinary bladder

López-Beltrán, Antonio; Montironi, Rodolfo; Raspollini, Maria Rosaria; Cheng, Liang; Netto, George J.

doi:10.1053/j.semdp.2018.03.001

Cited by 16 publications

(9 citation statements)

References 92 publications

(283 reference statements)

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“…A variety of other iatrogenic causes (e.g. chemotherapy) may induce florid reactive urothelial atypia, as recently reviewed …”

Section: Flat Urothelial Lesions With Atypiamentioning

confidence: 99%

“…chemotherapy) may induce florid reactive urothelial atypia, as recently reviewed. 15 Numerous studies have addressed the use of adjunctive immunohistochemistry in the diagnosis of CIS and its separation from reactive urothelial atypia. They may be utilised as single immunostains or multiplexed on a single slide.…”

Section: U R O T H E L I a L C A R C I N O M A I N S I T U ( C I S )mentioning

confidence: 99%

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Precursor lesions of the urinary bladder

McKenney

2018

Histopathology

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The classification of neoplastic precursor lesions in the urinary tract has evolved slowly with the gradual accumulation of clinicopathological data. Current nomenclature was codified most recently by the 2016 WHO classification, which is based on primary data with clinical outcome, consensus group statements and considerations of practical utility in routine diagnosis. This review discusses precursor lesions of urothelial, squamous and glandular lineage. For urothelial neoplasia, both flat lesions with atypia and early ‘difficult‐to‐classify’ proliferations are considered. Subtypes of squamous metaplasia, florid non‐invasive squamous proliferations and frank squamous dysplasia are also addressed. Finally, rare glandular precursors of adenocarcinoma are reviewed, to include intestinal metaplasia, glandular dysplasia and villous adenoma. For each category, morphology (including differential diagnostic considerations), immunohistochemistry and any known molecular correlates are detailed. The goal is to provide a concise, practical up‐to‐date overview of this complex topic.

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“…A variety of other iatrogenic causes (e.g. chemotherapy) may induce florid reactive urothelial atypia, as recently reviewed …”

Section: Flat Urothelial Lesions With Atypiamentioning

confidence: 99%

Section: U R O T H E L I a L C A R C I N O M A I N S I T U ( C I S )mentioning

confidence: 99%

Precursor lesions of the urinary bladder

McKenney

2018

Histopathology

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“…Although busulfan seems to be the agent most clearly involved with cytological atypia, other agents may cause or contribute to cytological atypical changes. Cyclophosphamide has also been associated with cytological alterations in the respiratory tract, breast, and urinary tract . However, no abnormalities in the uterine cervix have been described in association with cyclophosphamide in monotherapy or with cyclophosphamide in combination with other treatments different from busulfan.…”

Section: Discussionmentioning

confidence: 99%

Atypical cytological changes mimicking SIL of the uterine cervix in allogenic hematopoietic stem cell transplantation recipients treated with busulfan

Saco

Alós

Esteve

et al. 2019

Cancer Cytopathology

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BACKGROUND: Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human papillomavirus (HPV) persistence and, consequently, with an increased risk of cervical cancer (CC) and squamous intraepithelial lesions (SILs)-the precursors of CC. A gynecological check-up that includes CC screening is recommended in these patients. METHODS:All female recipients of allo-HSCT undergo routine gynecological check-up that includes CC screening. Cervical samples were obtained for liquid-based cytology and HPV testing. Cytology smears were stained with the Papanicolaou (Pap) technique. A colposcopy evaluation was performed if any abnormal result in the screening tests was obtained. RESULTS:Among 15 women undergoing gynecological examination at 1 year after allo-HSCT who had received a conditioning regimen that included busulfan, 4 (26.7%) showed atypical squamous cells in the Pap smear, suggesting high-grade SIL. The abnormalities were identified from 136 to 271 days after allo-HSCT. In all cases, HPV testing was negative, and colposcopy examination was normal. The cytological abnormalities regressed in 3 of the women after 1 year but persisted in 1 woman at day 382 after allo-HSCT. CONCLUSIONS: Treatment-related atypia mimicking SIL is a common finding in allo-HSCT recipients who have received busulfan, particularly in the first year after the procedure. However, atypical changes may persist for more than 1 year. Clinical information, HPV testing, and colposcopy examination are critical to prevent misdiagnosis and overtreatment in these patients.

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“…113 These have been the subject of recent publications and excellent reviews in the literature, and the findings are summarized in Table 5. [114][115][116] Immunohistochemical stains commonly used for reactive versus urothelial CIS (p53, CK20, CD44, racemase, Ki-67) should be interpreted with much caution in these settings.…”

Section: Therapy-related Diagnostic Issuesmentioning

confidence: 99%

The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia

Amin

Compérat

Epstein

et al. 2021

Advances in Anatomic Pathology

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The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder neoplasia with a focus on issues relevant to the practicing surgical pathologist for the understanding and effective reporting of bladder cancer, emphasizing particularly on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. The work is presented in 2 manuscripts. Here, in the first, we revisit the From the

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Iatrogenic pathology of the urinary bladder

Cited by 16 publications

References 92 publications

Precursor lesions of the urinary bladder

Precursor lesions of the urinary bladder

Atypical cytological changes mimicking SIL of the uterine cervix in allogenic hematopoietic stem cell transplantation recipients treated with busulfan

The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia

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