Ibogaine reduces organ colonization in murine systemic and gastrointestinal Candida albicans infections

Abstract

In the present study the effect of the indole alkaloid ibogaine on the in vitro lipolytic activity and adherence to epithelial cells of Candida albicans was investigated. The substance was administered intraperitoneally at a dose of 5 mg kg À1 day À1 in mice with disseminated and gastrointestinal C. albicans infections. Ibogaine significantly decreased the rate of mortality and the number of C. albicans c.f.u. recovered from the kidney, liver and spleen. Ibogaine interfered with the early stages of both disseminated and gastrointestinal C. albicans infections but did not reduce the number of C. albicans c.f.u. in the organs at the late phase of infections. The development of a specific immune response was not influenced by ibogaine, since the delayed-type hypersensitivity reaction to C. albicans and the production of interferon (IFN)-ª were similar in control and ibogainetreated mice. The combined use of amphotericin B plus ibogaine in the treatment of mice with gastrointestinal infection reduced organ colonization more strongly than each substance alone.

Vinca drug components accumulate exclusively in leaf exudates of Madagascar periwinkle

“…The spatial separation of vindoline and catharanthine appears to prevent dimer formation, perhaps because they may also interfere with cell division in Catharanthus as in cancer cells. The presence of catharanthine in the wax layer may also have a biological role, as shown with the MIA ibogaine that displays antifungal activity against Candida albicans (20). Incubation of catharanthine with zoospores of P. nicotianiae inhibits both growth of zoospores and the formation of hyphae at a concentration of 10 μg/mL of culture medium ( Table 1).…”

The ibogaine medical subculture

“…The possibility of an objective basis for the use of iboga in this setting is suggested by evidence associating iboga alkaloids with antimicrobial activity or effects on cell-mediated immunity. Iboga alkaloids are reportedly active against Candida albicans in the intact animal (Yordanov et al, 2005). In vitro studies indicate reversal of multidrug resistance in human cancer cells (Kam et al, 2004) and activity against Mycobacterium tuberculosis (Rastogi et al, 1998), human immunodeficiency type 1 virus (Silva et al, 2004), and the tropical parasite Leishmania amazonensis (Delorenzi et al, 2002).…”

Bioinspired Collective Syntheses of Iboga-Type Indole Alkaloids

“…The faceselective oxidation of C2/C3-fused indoles is a well-established method for hydroxyindolenines, which serve as precursors to the corresponding pseudoindoxyls. 10 Therefore, ibogaine (4) was successfully oxidized to ibogaine hydroxyindolenine (5) by using DMDO as oxidant from the less hindered face. 11 NaOH in refluxing MeOH induced ring contraction of ibogaine hydroxyindolenine (5) to give iboluteine (7) with the desired spiro configuration.…”

“…Recently, a series of new iboga-type alkaloids with skeletal variations have also been isolated . Iboga-type alkaloids show a wide range of pharmacological effects, such as antiaddiction, antifungal or antilipase, anti-HIV-1, anticholinesterasic, and leishmanicide activities . Their medicinal evaluations and application potential have motivated synthetic chemists to execute concise and efficient syntheses as well as convenient late-stage derivatizations for building large collections of biologically relevant molecules.…”