Ibuprofen and COVID-19 disease: separating the myths from facts

Poutoglidou, Frideriki; Saitis, Athanasios; Kouvelas, Dimitrios

doi:10.1080/17476348.2021.1951239

Cited by 21 publications

(19 citation statements)

References 40 publications

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“…Another potential challenge with purely content-based definitions is that when expert consensus on a public-health topic is rapidly emerging and subject to uncertainty and change, the definition of what is likely to be true and false can shift over time, making overly simplistic 'real' versus 'fake' categorizations a potentially unstable property. For example, although news media initially claimed that ibuprofen could worsen coronavirus symptoms, this claim was later retracted as more evidence became available 122 . The problem is that researchers often ask people how accurate or reliable they find a selective series of true and fake headlines that were either created or selected by the researchers on the basis of different definitions of what constitutes misinformation.…”

Section: Box 2 | the Challenges With Defining And Operationalizing Mi...mentioning

confidence: 99%

Misinformation: susceptibility, spread, and interventions to immunize the public

Linden

2022

Nat Med

284

152

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Section: Box 2 | the Challenges With Defining And Operationalizing Mi...mentioning

confidence: 99%

Misinformation: susceptibility, spread, and interventions to immunize the public

Linden

2022

Nat Med

284

152

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“…Studies have revealed a similar or improved analgesic effect of ibuprofen combined with or without other analgesics versus other analgesics in adult patients postoperatively. For pediatric and adolescent patients with moderate to severe pain, ibuprofen has also been documented with similar or better analgesic effects [ 11 , 12 ]. However, postoperative pain relief with ibuprofen for pediatric patients is marginally explored.…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy and Safety of Ibuprofen plus Traction, Reposition, and Hip Spica Cast in the Treatment of Developmental Dysplasia of the Hip

Feng

Liu

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To assess the clinical efficacy and safety of ibuprofen plus traction, reposition, and hip spica cast in the treatment of developmental dysplasia of the hip (DDH). Methods. Between January 2019 and July 2020, 60 children with DDH treaded in department of orthopedics of our institution were assessed for eligibility and recruited. They were assigned at a ratio of 1 : 1 to receive either traction + reposition + hip spica cast plus analgesia pump (observation group) or traction + reposition + hip spica cast plus analgesia pump and oral ibuprofen (control group). The outcome measures included clinical efficacy, pain scores, unexpected pain calls, the dosage of analgesia pump, and adverse events. Results. The two groups had similar clinical efficacy ( P > 0.05 ). The patients given oral ibuprofen were associated with significantly lower pain scores at 24 h and 72 h postoperatively versus those without oral ibuprofen ( P < 0.05 ). Analgesics with oral ibuprofen resulted in fewer unexpected pain calls versus analgesics without oral ibuprofen within 72 h postoperatively ( P < 0.05 ). The application of oral ibuprofen in the analgesia pump showed great improvement in lowering the dosage of analgesia pump versus the absence of ibuprofen ( P < 0.05 ). The incidence of adverse events was similar between the two groups of patients ( P > 0.05 ). Conclusion. Traction + reposition + hip spica cast plus analgesia pump and oral ibuprofen effectively mitigated postoperative pain in children with DDH and reduces analgesic drug dosage with a high safety profile.

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“…However, multiple regulatory bodies did not make recommendations in this regard due to lack of conclusive evidence. 73 …”

Section: Drug Used For Self-medication In Covid-19mentioning

confidence: 99%

Drug safety of frequently used drugs and substances for self-medication in COVID-19

Baracaldo-Santamaría

Pabón-Londoño

Rojas-Rodriguez

2022

Therapeutic Advances in Drug Safety

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During the COVID-19 pandemic, the behavior of self-medication has increased. The dissemination of misleading information regarding the efficacy of certain drugs or substances for the prevention and treatment of COVID-19 has been the major contributing factor for this phenomenon. Alongside with the increase in self-medication behavior, the inherent risks to this act such as drug–drug interactions, adverse events, drug toxicity, and masking of symptoms have also increased. Self-medication in the context of COVID-19 has led to drug misuse leading in some cases to the development of fatal adverse drug reactions. It is important that during this ongoing pandemic drugs with potential clinical efficacy against COVID-19 are adequately analyzed regarding their efficacy, safety, and monitoring. The aim of this review is to describe the available evidence regarding the efficacy, safety, and monitoring of the drugs and substances that have been shown to be frequently used for self-medication in patients with COVID-19 (hydroxychloroquine, non-steroidal anti-inflammatory drugs, ivermectin, azithromycin, vitamins, aspirin, and chlorine dioxide) to adequately characterize their risks, safe use, monitoring strategies, and to reinforce the concept that these substances should not be used for self-medication and require a medical prescription. Plain Language Summary Drug safety of frequently used drugs and substances for self-medication in COVID-19 Dissemination of information about potential COVID-19 treatments has led individuals to self-medicate and expose themselves to risks such as drug–drug interactions, side effects, antibiotic resistance, and misdiagnosis. There is a need to review the medical literature to evaluate the safety and efficacy of the drugs and substances commonly used by the population for the treatment and prevention of SARS CoV-2 infection. In this review, we included drugs that are frequently used for self-medication and commonly advertised such as ivermectin, hydroxychloroquine, chlorine dioxide, azithromycin, and non-steroidal anti-inflammatory drugs, among others. A brief introduction of the drug and its mechanism of action, followed by a summary of the efficacy in COVID-19 and safety, will be described for each drug in order to promote their responsible use.

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Ibuprofen and COVID-19 disease: separating the myths from facts

Cited by 21 publications

References 40 publications

Misinformation: susceptibility, spread, and interventions to immunize the public

Misinformation: susceptibility, spread, and interventions to immunize the public

Clinical Efficacy and Safety of Ibuprofen plus Traction, Reposition, and Hip Spica Cast in the Treatment of Developmental Dysplasia of the Hip

Drug safety of frequently used drugs and substances for self-medication in COVID-19

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