Ibuprofen in the current practice of the pharmacist in the community pharmacy

Antonoaea, Paula; Todoran, Nicoleta; Rédai, Emőke; Vlad, Robert Alexandru; BÎRSAN, MAGDALENA; Rusu, Aura; Ciurba, Adriana

doi:10.37897/rjphp.2020.3.1

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“…Throughout the testing period, the products were stored at 8 -15°C, in tightly closed containers. At the end of each cycle, the samples were checked to see whether there was any change or relevant signs that identify instability, for example, foaming or signs of phase separation [24][25][26][27][28][29]. pH measurement Samples of 5.0 g from each cream base were heated in 15 g of distilled water until the fat phase melted, stirred for one minute, cooled to 20C, and filtered through a paper filter [25].…”

Section: Accelerated Stability Study By Mechanical Stressmentioning

confidence: 99%

“…A standard penetrometer (ACME-103, India) was used, adding progressively weights of 5 g, up to 30 g, recording the penetration depth (mm). All the measurements were performed in triplicate, at 25°C [26,27]. The penetrometric curves were obtained representing the penetration depth (mm) against mass (g).…”

Section: Consistency Measurementmentioning

confidence: 99%

“…All the measurements were conducted in triplicate, at 25°C. The extensometric curves were obtained representing the spreading surface (mm 2 ) against mass (g) [26][27][28].…”

Section: Spreadabilitymentioning

confidence: 99%

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Development and Evaluation of Hydrophilic Cream Bases Suitable for Custom Cosmetic Skincare or Compounding Pharmaceutical Dermal Products

BÎRSAN¹

2022

FARMACIA

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This study aimed to formulate, prepare and characterize cream bases used to make individualized preparations for patients: compounding pharmaceutical or cosmeceutical preparations. In terms of consistency, FIII, which is formulated with 3% stearic acid, 3.5% polyglyceryl-3 methylglucose distearate, and 65.5% Centaurea cyanus flower water, can be recommended as a first choice when an easy spreading capacity on the skin is required. Comparative rheological analysis showed a plastic behaviour for all the proposed formulas, while when evaluating the restructuring behaviour during shearing with successive decreasing speeds, a hysteresis loop was observed. The skin tolerance and the degree of hydration obtained after applying the cream were evaluated. Under the experimental conditions adopted in the screening test, the single application of the proposed products showed good compatibility with the skin. The tests on the 6 human subjects for FI, which is formulated with 3% stearic acid, 3% polyglyceryl-3 methylglucose distearate and 66% Centaurea cyanus flower water, confirmed an increased level of hydration level, on average by 12.8% compared to the zero moment (when the cream was not applied) and for FIII an increase over 6.5%. From the obtained results, two cream bases for compounding pharmaceutical or cosmeceutical preparations formulas with a lower percentage of incorporated stearic acid can be proposed, respectively FI and FIII. RezumatScopul acestui studiu a constat în formularea, prepararea și caracterizarea unor baze de cremă utilizate în vederea realizării preparatelor individualizate pentru pacienți: preparate farmaceutice magistrale sau cosmeceutice. Din punctul de vedere al consistenței, baza de cremă FIII, formulată cu acid stearic 3%, distearat de poligliceril-3 metil glucoză 3,5% și apă de albăstrele 65,5%, poate fi recomandată ca primă alegere atunci când se dorește o capacitate de etalare facilă pe piele. Analiza reologică comparativă a demonstrat pentru toate formulele propuse un comportament plastic, iar la evaluarea comportamentului privind restructurarea din timpul forfecării cu viteze succesive descrescătoare s-a evidențiat bucla de histereză. Au fost evaluate toleranța cutanată și gradul de hidratare obținut după aplicarea cremei. În condițiile experimentale adoptate în testul screening, aplicarea unică a produselor propuse a arătat o bună compatibilitate cu pielea. Evaluarea gradului de hidratare al stratului cornos a indicat că toate formulele propuse au efect hidratant la patru ore după aplicare, observânduse o compatibilitate optimă. În cazul formulării FI, ce conține acid stearic 3%, distearat de poligliceril-3 metil glucoză 3% și apă de albăstrele 66%, testările pe cei 6 subiecți umani au confirmat creșterea nivelului de hidratare în medie cu 12,8% față de momentul zero, iar pentru FIII o creștere de peste 6,5%. FII a crescut gradul de hidratare doar cu 0,7%, iar pentru FIV valorile au crescut cu 5,5%.Din rezultatele obținute se pot propune ca baze de cremă pentru preparate farmaceutice magi...

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