Ibuprofen liquigel for oral surgery pain

Hersh, Elliot V.; Levin, Lawrence M.; Cooper, Stephen A.; Doyle, Geraldine; Waksman, Joel; Wedell, David; Hong, Douglas; Secreto, Stacey A.

doi:10.1016/s0149-2918(00)83027-1

Cited by 70 publications

(59 citation statements)

References 15 publications

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“…The plasma S/R ratio can vary according to the time-release characteristics of the formulation with higher ratios being obtained with sustained-release (SR) compared with immediate-release (IR) formulations, respectively (Ding et al 2007). A liquid or liquigel formulation of ibuprofen has proven to be popular for rapid analgesia which is related to fast absorption (Laska et al 1986;Seymour et al 1991;Hersh et al 2000b). Table 1 summarizes the pharmacokinetic properties of R/S-ibuprofen, the data for which has been derived from various studies in volunteers and patients with arthritic conditions.…”

Section: Pharmacokinetics In Adultsmentioning

confidence: 99%

Ibuprofen: pharmacology, efficacy and safety

2009

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This assessment of the safety and benefits of ibuprofen can be summarized thus: (1) Ibuprofen at OTC doses has low possibilities of serious GI events, and little prospect of developing renal and associated CV events. Ibuprofen OTC does not represent a risk for developing liver injury especially the irreversible liver damage observed with paracetamol and the occasional liver reactions from aspirin. (2) The pharmacokinetic properties of ibuprofen, especially the short plasma half-life of elimination, lack of development of pathologically related metabolites (e.g. covalent modification of liver proteins by the quinine-imine metabolite of paracetamol or irreversible acetylation of biomolecules by aspirin) are support for the view that these pharmacokinetic and notably metabolic effects of ibuprofen favour its low toxic potential. (3) The multiple actions of ibuprofen in controlling inflammation combine with moderate inhibition of COX-1 and COX-2 and low residence time of the drug in the body may account for the low GI, CV and renal risks from ibuprofen, especially at OTC doses.

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Section: Pharmacokinetics In Adultsmentioning

confidence: 99%

Ibuprofen: pharmacology, efficacy and safety

2009

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“…One recent modification is the use of gel caps that provide faster absorption and therefore a quicker onset for meaningful analgesia that occurs about 25-30 minutes after ingestion. 15,[40][41][42] Another recent advance in formulation includes a mucoadhesive patch that permits intra-oral delivery of ibuprofen. 43 Other modifications to ibuprofen include the addition of other drugs such as hydrocodone or oxycodone (which enhances ibuprofen analgesia but with a concomitant increase in adverse effects) 30,44 and paracetamol (1000mg) to ibuprofen (600mg).…”

Section: Trials/efficacymentioning

confidence: 99%

Drugs for pain management in dentistry

Hargreaves

Abbott

2005

Australian Dental Journal

104

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Pain is one of the most common reasons patients seek dental treatment. It may be due to many different diseases/conditions or it may occur after treatment. Dentists must be able to diagnose the source of pain and have strategies for its management. The '3-D's' principle -diagnosis, dental treatment and drugs -should be used to manage pain. The first, and most important, step is to diagnose the condition causing the pain and identify what caused that condition. Appropriate dental treatment should then be undertaken to remove the cause of the condition as this usually provides rapid resolution of the symptoms. Drugs should only be used as an adjunct to the dental treatment. Most painful problems that require analgesics will be due to inflammation. Pain management drugs include non-narcotic analgesics (e.g., non-steroidal anti-inflammatory drugs, paracetamol, etc) or opioids (i.e., narcotics). Nonsteroidal anti-inflammatory drugs (NSAIDs) provide excellent pain relief due to their anti-inflammatory and analgesic action. The most common NSAIDs are aspirin and ibuprofen. Paracetamol gives very effective analgesia but has little anti-inflammatory action. The opioids are powerful analgesics but have significant side effects and therefore they should be reserved for severe pain only. The most commonlyused opioid is codeine, usually in combination with paracetamol. Corticosteroids can also be used for managing inflammation but their use in dentistry is limited to a few very specific situations.Key words: Dentistry, pain, analgesics, non-steroidal antiinflammatory drugs, NSAIDs.Abbreviations and acronyms: ACTH = adrenocorticotrophic hormone; CNS = central nervous system; NSAIDs = non-steroidal anti-inflammatory drugs.Aust Dent J 2005;50 Suppl 2:S14-S22

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“…However, with nimesulide the onset of action was more rapid than with the other drugs tested, and only in nimesulide-treated patients was the effect already evident 15 minutes after taking ( Figure 2). Such a fast onset of analgesia could only be approached with special rapid release formulations of other NSAIDs 48,49 . The efficacy of nimesulide (100 mg b.i.d.)…”

Section: Clinical Evidence In Patients With Different Types Of Acute mentioning

confidence: 99%