Ibuprofen-loaded electrospun poly(ethylene-<i>co</i>-vinyl alcohol) nanofibers for wound dressing applications

Schoeller, Jean; Avaro, Jonathan; Chung, Michael T.; Elbs-Glatz, Yvonne; Rottmar, Markus; Ferguson, Stephen J.; Wuertz‐Kozak, Karin; Rossi, René M.

doi:10.1039/d3na00102d

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…The reason for the less amount of released IBU from nanofibers in water (pH ∼ 5.5) and buffer solution at pH 3.5 values was attributed to hydrophobic interactions between IBU and the polymer backbone of the nanofiber. This hydrophobic interaction was also reported in nanoparticles 71 and nanofibers 72 and led to a desorption limiting release mechanism of the drug.…”

Section: Synthesis Of Monomers and Polymers Conjugatedsupporting

confidence: 62%

Cascade Release of Payloads from Polymer Nanofibers with Conjugated Hydrotropes and Kosmotropes

Kongkatigumjorn,

Crespy

2024

Macromolecules

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Over 60% of hydrophobic substances currently exploited in the pharmaceutical industry encounter a reduction of therapeutic efficacy due to limited water solubility. Herein, we report a strategy for exhibiting a sustained and large amount of released payloads while allowing for their controlled release upon specific conditions. The strategy relies on the conjugation of solubilizers to polymers via responsive linkages, which are used as a matrix for the encapsulation of payloads. In the presence of mild acidic conditions, hydrotropes and kosmotropes are released from polymer nanofibers after cleavage of thioether ester linkages, subsequently inducing the release of drugs and dyes used as model payloads. This approach can be applied for preparing materials for an enhanced delivery of hydrophobic sensor molecules, drugs, phytosanitary treatments, or corrosion inhibitors.

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Section: Synthesis Of Monomers and Polymers Conjugatedsupporting

confidence: 62%

Cascade Release of Payloads from Polymer Nanofibers with Conjugated Hydrotropes and Kosmotropes

Kongkatigumjorn,

Crespy

2024

Macromolecules

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“…The easiest way to test cytotoxicity caused by the material according to the ISO 10993–5:2009 standard is to make a material extract [ 13 ], which is also widely used to investigate ES fiber material cytotoxicity [ 19 , 23 – 25 ]. This means that the material is usually immersed in the cell medium and incubated for a specified period.…”

Section: Resultsmentioning

confidence: 99%

“…A recent report has shown the importance of complementary analytical methods for the characterisation of ES materials [ 15 ]. Furthermore, different cell lines have been used for cytotoxicity testing, mainly in mouse fibroblasts and human skin fibroblasts [ 9 , 15 – 19 ]. When using different methods and cells, the exact technical procedures during testing may affect the results of the experiments and their interpretation and are important to be explored in more detail.…”

Section: Introductionmentioning

confidence: 99%

In vitro experimental conditions and tools can influence the safety and biocompatibility results of antimicrobial electrospun biomaterials for wound healing

Põhako-Palu,

Lorenz,

Randmäe

et al. 2024

PLoS ONE

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Electrospun (ES) fibrous nanomaterials have been widely investigated as novel biomaterials. These biomaterials have to be safe and biocompatible; hence, they need to be tested for cytotoxicity before being administered to patients. The aim of this study was to develop a suitable and biorelevant in vitro cytotoxicity assay for ES biomaterials (e.g. wound dressings). We compared different in vitro cytotoxicity assays, and our model wound dressing was made from polycaprolactone and polyethylene oxide and contained chloramphenicol as the active pharmaceutical ingredient. Baby Hamster Kidney cells (BHK-21), human primary fibroblasts and MTS assays together with real-time cell analysis were selected. The extract exposure and direct contact safety evaluation setups were tested together with microscopic techniques. We found that while extract exposure assays are suitable for the initial testing, the biocompatibility of the biomaterial is revealed in in vitro direct contact assays where cell interactions with the ES wound dressing are evaluated. We observed significant differences in the experimental outcome, caused by the experimental set up modification such as cell line choice, cell medium and controls used, conducting the phosphate buffer washing step or not. A more detailed technical protocol for the in vitro cytotoxicity assessment of ES wound dressings was developed.

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Localized delivery of healing stimulator medicines for enhanced wound treatment

Al-Musawi,

Turki,

Al-Naymi

et al. 2024

Journal of Drug Delivery Science and Technology

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Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

Abstract: Chronic wounds are characterized by a prolonged inflammation phase preventing the normal processes of wound healing and natural regeneration of the skin. To tackle this issue, electrospun nanofibers, inherently possessing...

Cited by 3 publications

References 57 publications

Cascade Release of Payloads from Polymer Nanofibers with Conjugated Hydrotropes and Kosmotropes

Cascade Release of Payloads from Polymer Nanofibers with Conjugated Hydrotropes and Kosmotropes

In vitro experimental conditions and tools can influence the safety and biocompatibility results of antimicrobial electrospun biomaterials for wound healing

Localized delivery of healing stimulator medicines for enhanced wound treatment

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