Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release

Luan,

doi:10.2147/ijn.s17011

Cited by 15 publications

(5 citation statements)

References 27 publications

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“…(3) Higuchi; and (4) Ritger-Peppas (Pang et al 2011). The linearity of each function was assessed by regression analysis to obtain the linear equation and linear regression coefficient (R) of each release profile.…”

Section: Mathematical Modeling Of Drug Deliverymentioning

confidence: 99%

Synthesis of pH-sensitive poly(β-amino ester)-coated mesoporous silica nanoparticles for the controlled release of drugs

et al. 2018

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This report describes the synthesis of a controlled drug delivery system that was obtained by coating mesoporous silica nanoparticles (MSNs) with poly(β-amino ester) (PbAE), which is a solid and stable material at physiological pH, but is dissolved at acidic pH values, such as those in tumor tissues (from 5.0 to 6.5). To synthesize the system, PbAE chains were grafted onto amino-functionalized MSNs through a reaction between the surface amino groups of MSNs and the ends of acrylate chains of a PbAE. The system was physicochemically characterized by dynamic light scattering (DLS), Fourier transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis, X-ray photoelectron spectrometry, and X-ray diffraction analyses. In addition, the in vitro release of doxorubicin (DOX) and doxycycline (DXY) in acidic and physiological media was evaluated. It was observed that the PbAE modification did not affect the mesoporous structure of MSNs. When the amount of 3-aminopropyltriethoxysilane was increased during functionalization, the amount of PbAE binding to MSNs increased as well. With respect to drug release, the sample with the highest amount of PbAE showed better control in the delivery of DXY and DOX in acidic media, because at pH 5.5, the release of both drugs was 40% higher than that at pH 7.4. These results reveal two aspects about the presence of PbAE in MSNs: PbAE does not affect the mesoporous structure of the nanoparticles, and PbAE is the main factor controlling the delivery of drugs in acidic media.

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Section: Mathematical Modeling Of Drug Deliverymentioning

confidence: 99%

Synthesis of pH-sensitive poly(β-amino ester)-coated mesoporous silica nanoparticles for the controlled release of drugs

et al. 2018

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“…High drug loading means severe burst release, while poor drug loading brings well-controlled drug release. 46 As to OSDP LNPs ( Figure S2 ), higher drug loading also led to a little burst release within the first 8 h, which might come from the exposed OEA crystals and the OEA on the surface of the LNPs. Compared to the OEA crystals without the coverage of lipid bilayer, this slight burst release could be neglected.…”

Section: Resultsmentioning

confidence: 90%

Endogenous Oleoylethanolamide Crystals Loaded Lipid Nanoparticles with Enhanced Hydrophobic Drug Loading Capacity for Efficient Stroke Therapy

Wu¹,

Liao²,

Li³

et al. 2021

IJN

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Introduction:Although the preparation of lipid nanoparticles (LNPs) achieves great success, their retention of highly hydrophobic drugs is still problematic. Methods: Herein, we report a novel strategy for efficiently loading hydrophobic drugs to LNPs for stroke therapy. Oleoylethanolamide (OEA), an endogenous highly hydrophobic molecule with outstanding neuroprotective effect, was successfully loaded to OEA-SPC&DSPE-PEG lipid nanoparticles (OSDP LNPs) with a drug loading of 15.9 ± 1.2 wt %. Efficient retention in OSDP LNPs greatly improved the pharmaceutical property and enhanced the neuroprotective effect of OEA. Results: Through the data of positron emission tomography (PET) and TTC-stained brain slices, it could be clearly visualized that the acute ischemic brain tissues were preserved as penumbral tissues and bounced back with reperfusion. The in vivo experiments stated that OSDP LNPs could significantly improve the survival rate, the behavioral score, the cerebral infarct volume, the edema degree, the spatial learning and memory ability of the MCAO (middle cerebral artery occlusion) rats. Discussion: These results suggest that the OSDP LNPs have a great chance to develop hydrophobic OEA into a potential anti-stroke formulation.

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“…These case studies and research findings underscore the versatility and efficacy of nanofibrous materials across diverse therapeutic applications. They demonstrate the potential of nanofiber-based approaches to advance the fields of wound healing, tissue engineering, regenerative medicine, and targeted drug delivery for improved patient outcome [19][20][21][22][23][24][25] .…”

Section: Anti-inflammatory Drug Delivery -Inflammatory Disordersmentioning

confidence: 94%

Untitled

2024

Nat. J. Pharm. Sci.

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This article delves into the transformative potential of nanofiber technology in pharmaceuticals and its profound impact on healthcare. Nanofibers, with their unique properties, are revolutionizing drug delivery systems, wound healing, and diagnostic applications. The versatility of nanofibers allows for precise control over drug release, enabling targeted therapies and personalized medicine. Examples include nanofiber wound dressings that expedite healing and drug delivery systems with enhanced efficacy and reduced side effects. The integration of nanofibers with biosensors facilitates sensitive and rapid diagnostics, paving the way for early disease detection. Furthermore, nanofibers play a pivotal role in tissue engineering, creating scaffolds that mimic the natural extracellular matrix and support tissue regeneration. This has implications for regenerative medicine, offering innovative solutions for bone, nerve, and dental tissue regeneration. The article emphasizes the potential of nanofiber applications in neural interfaces, respiratory protection, and even space exploration. While highlighting successful case studies and breakthroughs, the article addresses challenges like regulatory considerations, scalability issues, and biocompatibility concerns. It emphasizes the need for collaborative efforts between researchers, industry stakeholders, and regulatory bodies to overcome these challenges. The transformative impact of nanofibers extends to improved treatment outcomes, enhanced patient care, and increased efficiency in healthcare delivery. The narrative underscores the significance of ongoing research, encouraging exploration in this dynamic field. As nanofiber technology continues to evolve, it holds the promise of shaping a future where healthcare is personalized, efficient, and marked by innovative solutions that significantly improve the well-being of patients.

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Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release

Cited by 15 publications

References 27 publications

Synthesis of pH-sensitive poly(β-amino ester)-coated mesoporous silica nanoparticles for the controlled release of drugs

Synthesis of pH-sensitive poly(β-amino ester)-coated mesoporous silica nanoparticles for the controlled release of drugs

Endogenous Oleoylethanolamide Crystals Loaded Lipid Nanoparticles with Enhanced Hydrophobic Drug Loading Capacity for Efficient Stroke Therapy

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