Ibuprofen: Pharmacology, Therapeutics and Side Effects

Rainsford, K. D.

doi:10.1007/978-3-0348-0496-7

Cited by 51 publications

(73 citation statements)

References 366 publications

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“…La seguridad del ibuprofeno se basa en la administración de menos de 1.200 mg al día durante 7-10 días [2,9]. Diferentes estudios europeos constatan que si se supera esta dosis y/o se administra ibuprofeno a largo plazo puede provocar problemas cardiovasculares graves [4,5,13,14].…”

Section: Discussionunclassified

“…Su mecanismo de acción es debido a la inhibición de la síntesis de prostaglandinas mediante la inhibición de la ciclooxigenasa (COX-1 y COX-2). Las prostaglandinas desempeñan un papel esencial en la aparición de la fiebre, el dolor y la inflamación [1,2].…”

Section: Introductionunclassified

“…El objetivo era encontrar fármacos con una mayor eficacia que Aspirina® y los corticoides para tratar la artritis reumatoide [2]. Hoy en día se trata de un medicamento mundialmente conocido, que forma parte de los medicamentos indispensables en la lista de la Organización Mundial de la Salud [3].…”

Section: Introductionunclassified

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Utilización de ibuprofeno por los usuarios de la farmacia comunitaria

Timoneda¹

2017

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RESUMENIntroducción: Ibuprofeno es un antiinflamatorio no esteroideo con propiedades antiinflamatorias, analgésicas y antipiréticas. La seguridad de ibuprofeno fue revisada en 2006 y finalmente en 2015 se confirmó que la administración de dosis altas de ibuprofeno se asocia a un mayor riesgo de trombosis arterial.Objetivos: Comprobar la utilización de ibuprofeno por los usuarios de la farmacia comunitaria.Material y métodos: Los datos de este estudio descriptivo, observacional y transversal se obtienen del cuestionario realizado a los clientes habituales de una farmacia de Barcelona, previamente firmando una hoja de consentimiento y finalmente dando consejos mediante un tríptico informativo.Resultados: Se incluyeron 40 personas que superaban los criterios de inclusión, de las que sólo una persona tenía ibuprofeno como tratamiento crónico. El 82,5% utilizaba la dosis de 600 mg y un 15,0% la de 400 mg con una posología predominante, en ambos casos, de cada 8 horas. Un 55,0% del total utilizaba ibuprofeno hasta que remitía el dolor y los usos resultaron variados, quedando en primera posición el dolor de cabeza.Discusión: No se puede corroborar qué dosis es la más predominante en otros países, pero sí podemos aclarar que en algunos, como es el caso de Francia, la dosis de 600 mg no está comercializada. Esta resulta ser la dosis más usada entre los encuestados superando la dosis máxima de 1.200 mg al día recomendada para evitar un posible riesgo cardiovascular. Por otra parte, todas las indicaciones del ibuprofeno que usan los encuestados son correctas, con excepción de la del resfriado que en España no está admitida. Using ibuprofen among users of community pharmacies ABSTRACTIntroduction: Ibuprofen is a non-steroidal anti-inflammatory with anti-inflammatory, analgesic and antipyretic properties. The safety of ibuprofen was revised in 2006 and finally in 2015 it was confirmed that administration of high doses of ibuprofen is associated with an increased risk of arterial thrombosis.Objectives: Testing the use of ibuprofen by users of the community pharmacy. Material and methods: Data from this study descriptive, observational and cross-sectional are obtained from questionnaire of regular customers of the pharmacy in particular before signing a consent form and then being given advice through an information leaflet.Results: 40 people were included exceeding the inclusion criteria, of which only one person had ibuprofen as chronic treatment. 82.5% used doses of 600 mg and 15.0% of 400 mg with a predominant dosage, every 8 hours, in both cases. 55.0% of people used ibuprofen until the pain subsided and uses were varied, being headache in first position.Discussion: No one can corroborate what dose is most prevalent in other countries, but we can clarify that the dose of 600 mg is not marketed in some of them, such as France. This turns out to be the most used doses among the survey respondents exceeding the maximum dose of 1200 mg per day recommended by AEMPS to avoid a possible cardiovascular risk. Moreover, all ibuprof...

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Section: Discussionunclassified

Section: Introductionunclassified

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Utilización de ibuprofeno por los usuarios de la farmacia comunitaria

Timoneda¹

2017

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“…Ibuprofen functions by inhibiting cyclooxygenase (COX), an enzyme which participates in the arachidonic acid cascade towards prostaglandin synthesis. Prostaglandins are important mediators of inflammation and pain in the human body [34]. After being approved for over-the-counter use, annual ibuprofen prescriptions have grown to 20 million encompassing such brands as Advil, Motrin, Nuprin, Rufen and Trendar [35].…”

Section: Bhc Ibuprofen Synthesis: a Perspective On Intrinsic Efficiencymentioning

confidence: 99%

Green Chemistry and Associated Metrics

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2014

SpringerBriefs in Molecular Science

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This chapter provides an overview of green metrics and their historical role in promoting the development of green chemistry. Starting with the history of the field, the Twelve Principles of Green Chemistry are introduced and discussed in conjunction with a "green-by-design" approach recently applied to the synthesis of Lipitor ® . Various perspectives on synthetic efficiency are briefly outlined with reference to atom economy and E factor. These ideas are further explored in the context of three industrial processes which have received Presidential Green Chemistry Challenge Awards. The synthesis of ibuprofen is examined from the point of view of intrinsic efficiency. Using the BHC process as an example, several benefits associated with the use of catalysis are discussed, with an emphasis placed on designing atom-efficient reactions. A global perspective centered around the production of chemical waste is also outlined with reference to Merck's commercial synthesis of Januvia ® , a medication for the treatment of type II diabetes. Finally, Pfizer's new sertraline process is used to describe ways of improving both quantitative as well as qualitative aspects of an industrial synthesis. The chapter concludes with a brief outline of the future directions of green metrics.

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“…It is also used for pericarditis and patent ductus arteriosus. [1][2][3][4][5][6][7][8] Codeine phosphate…”

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confidence: 99%