2022
DOI: 10.1016/j.ejphar.2022.175256
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Ibuprofen treatment ameliorates memory deficits in rats with collagen-induced arthritis by normalizing aberrant MAPK/NF-κB and glutamatergic pathways

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Cited by 6 publications
(3 citation statements)
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“…5c ). Previous studies have reported that anti-inflammatory agent ibuprofen showed inhibitory effect on nuclear transcription factor-kappa B (NF-κB) 44 , 45 , and knockout of p50 (NF-κB subunit) reduced the expression of Irg1 in BMDMs 46 . To investigate the relationship between NF-κB (p50) and Irg1 , we treated BMDMs with ibuprofen and found attenuated binding activity of p50 to the promoter of the Irg1 gene by ChIP‒PCR (Supplementary Fig.…”
Section: Resultsmentioning
confidence: 99%
“…5c ). Previous studies have reported that anti-inflammatory agent ibuprofen showed inhibitory effect on nuclear transcription factor-kappa B (NF-κB) 44 , 45 , and knockout of p50 (NF-κB subunit) reduced the expression of Irg1 in BMDMs 46 . To investigate the relationship between NF-κB (p50) and Irg1 , we treated BMDMs with ibuprofen and found attenuated binding activity of p50 to the promoter of the Irg1 gene by ChIP‒PCR (Supplementary Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, epidemiological studies also showed an association between periodontitis and dementia ( 40 , 64 , 65 ). A previous study reported that non-steroidal anti-inflammatory drugs (NSAIDs) reduced the risk of dementia in collagen-induced arthritis (CIA) by normalizing the activated mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways ( 66 ). More biological studies are warranted to determine the relationship between RA and reduction in dementia.…”
Section: Discussionmentioning
confidence: 99%
“…[11][12][13][14]16 Interestingly, diclofenac appeared to regulate osteoclast differentiation by stabilizing the inactive form of NF-κB, 13 whereas ibuprofen given to rats with collagen-induced arthritis inhibited neuroinflammation in the hippocampus by attenuating the NF-κB cascade, and contributed to the memory improvement. 18 This latter example shows that the presence of inflammatory processes and activation of the immune system may affect the CNS and trigger or exacerbate neuroinflammation. It was further demonstrated that inflammatory mediators are implicated in depressive symptoms by directly affecting brain tissue, modulating the monoaminergic system and initiating neurotoxic processes in brain areas responsible for emotions and emotional memories.…”
Section: Nsaids Anti-inflammatory Mechanism Of Action Through the Nf-κbmentioning
confidence: 99%