Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury

Park, Andrew J; Anderson, Dustin; Battaglino, Ricardo A.; Nguyen, Nguyen M; Morse, Leslie R.

doi:10.1080/10790268.2020.1773029

Cited by 15 publications

(12 citation statements)

References 49 publications

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“…Mean differences in IL-6 levels were found to be statistically significant for all group comparisons and both time ranges examined. A study on chronic spinal trauma treatment conducted by Park et al showed that ibuprofen decreased IL-6 levels to 3.2 pg/ml in the treatment group, compared with 4.0 pg/ml in the control group [17]. IL-6 is one of the cytokines and a mediator of induction and control of acute phase protein synthesis released by hepatocytes during painful stimuli such as trauma, infection, surgery, and burns [18].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Pain Control and Inflammatory Profile in Cesarean Section Patients Treated with Multimodal Analgesia Utilizing Paracetamol and Ibuprofen

Gaus

Afif

Ambo

et al. 2023

Open Access Maced J Med Sci

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AIM: This single-blind study aimed to compare the combination of paracetamol with various doses of ibuprofen as multimodal analgesia in C-section surgery patients under spinal anesthesia. Levels of interleukin (IL)-6 and C-reactive protein (CRP) were analyzed as markers of inflammation. METHODS: Treatment groups (20 patients each) were: Group A, 750 mg paracetamol and 400 mg ibuprofen; Group B, 750 mg paracetamol and 600 mg ibuprofen; and Group C, 750 mg paracetamol and 800 mg ibuprofen. Degree of pain (movement and rest), scored using the numeric rating scale (NRS) and levels of IL-6 and CRP were assessed at various time points within 24 h of surgery. Side effects and numbers of subjects requiring rescue fentanyl administration were also recorded. RESULTS: Group C showed a rest NRS score of 1.00 ± 0.00 6 h postoperatively, compared with 2.00 ± 0.00 in Group B and 2.35 ± 0.87 in Group A. 4 h postoperatively, movement NRS scores were 1.00 ± 0.00 for Group C, compared to 3.00 ± 1.77 for Group B, and 4.85 ± 1.81 for Group A. At 12 h, IL-6 levels hours were 2.66 ± 0.04 pg/mL for Group A, 2.39 ± 0.02 pg/mL for Group B, and 2.05 ± 0.01 pg/mL for Group C. At 6 h, CRP levels were 1.18 ± 0.04 mg/L for Group A, 0.95 ± 0.01 mg/L for Group B, and 0.70 ± 0.02 mg/L for Group C. Overall, Group C showed the lowest values for all parameters analyzed, compared with other groups, and the differences were significant (p < 0.05). In addition, none of the patients in Group C required rescue fentanyl (p < 0.05), and no patients in any of the groups showed any side effects. CONCLUSION: For pain management after C-section surgery, the combination of 750 mg paracetamol and 800 mg ibuprofen yielded the best results as assessed by NRS scores, levels of IL-6 and CRP, and fentanyl rescue.

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Section: Discussionmentioning

confidence: 99%

Comparison of Pain Control and Inflammatory Profile in Cesarean Section Patients Treated with Multimodal Analgesia Utilizing Paracetamol and Ibuprofen

Gaus

Afif

Ambo

et al. 2023

Open Access Maced J Med Sci

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“…PCT also has a significantly higher accuracy than CRP for discriminating between bacterial and viral infections or non-infective causes of inflammation [ 41 ]. In addition, unlike CRP, the PCT level is unaffected by the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids and by various inflammatory comorbidities (e.g., autoimmune diseases) [ 42 , 43 , 44 , 45 ]. These advantages are especially helpful for children who have previously been administered NSAIDs for symptomatic treatment prior to hospital visit [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Procalcitonin Level as a Diagnostic Marker of Pediatric Bacterial Meningitis: A Systematic Review and Meta-Analysis

2021

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Early diagnosis and treatment of bacterial meningitis in children are essential, due to the high mortality and morbidity rates. However, lumbar puncture is often difficult, and cerebrospinal fluid (CSF) culture takes time. This meta-analysis aims to determine the diagnostic accuracy of blood procalcitonin for detecting bacterial meningitis in children. We conducted a systematic search on electronic databases to identify relevant studies. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated, and a hierarchical summary receiver operating characteristic curve and area under the curve (AUC) were determined. Eighteen studies with 1462 children were included in the analysis. The pooled sensitivity, specificity, and the DOR of blood procalcitonin for detecting bacterial meningitis were 0.87 (95% confidence interval (CI): 0.78–0.93); 0.85 (95% CI: 0.75–0.91), and 35.85 (95% CI: 10.68–120.28), respectively. The AUC for blood procalcitonin was 0.921. Blood procalcitonin also showed higher diagnostic accuracy for detecting bacterial meningitis than other conventional biomarkers, including serum C-reactive protein and leukocyte count, CSF leukocyte and neutrophil count, and CSF protein and glucose levels. Blood procalcitonin can be a good supplemental biomarker with high diagnostic accuracy in detecting bacterial meningitis in children.

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“…Ibuprofen merupakaj salah satu golongan dari OAINS yang sudah sangat dikenal dan telah digunakan (Singla et al, 2010). Ibuprofen intravena bekerja dengan menghambat enzim COX-1 dan COX-2 dalam mengkonversi asam arakhidonat menjadi prostaglandin yang termasuk juga didalamnya tromboksan dan prostasiklin (Park et al, 2022). Dexamethasone merupakan suatu isomer dari betamethasone dan bekerja pada reseptor glukokortikoid (De Oliveira et al, 2011).…”

Section: Diskusi Skala Nyeri Dan Opioid Pascabedahunclassified

“…Glukokortikoid dan reseptor glukokortikoid berada pada puncak system regulator yanga beberapa jalur inflamasi. Glukokortikoid dapat menghambat prostaglandin melalui tiga mekanisme: induksi dan aktivasi annexin I, induksi MAPK (mitogen activated protein kinase) phosphatase, dan penghambatan COX 2 (El Azab et al, 2002); (Park et al, 2022).…”

Section: Diskusi Skala Nyeri Dan Opioid Pascabedahunclassified

Perbandingan Preventif Analgesia Ibuprofen 800 Mg Kombinasi Dexamethasone 10 Mg Intravena Terhadap Intensitas Nyeri Pascabedah Dekompresi Dan Stabilisasi Posterior

Darise

Ambo²,

Gaus

2022

kesehatan

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Pendahuluan: Nyeri pascabedah pada pasien yang menjalankan operasi dekompresi dan stabilisasi posterior tulang belakang akut dengan derajat nyeri sedang hingga berat. Pemberian preventif pada pasien menjalankan operasi dekompresi dan stabilisasi posterior tulang belakang diberikan ibuprofen kombinasi dexamethasone intravena dan belum ada yang melakukan penelitian dengan memakai ibuprofen kombinasi dexamethasone intravena. Tujuan penelitian ini adalah pemberian preventif ibuprofen 800 mg kombinasi deksametasone 10 mg dan ibuprofen 800 mg dalam menurunkan intensitas nyeri pasien pascabedah dekompresi dan stabilisasi posterior. Metode: Desain penelitian single blind randomized experimental clinical trial yang dilakukan di RSUP dr. Wahidin Sudirohusodo mulai bulan Juni-September 2021 yang dibagi menjadi 2 kelompok, kelompok A (Ibuprofen 800 mg + Dexamethasone 10 mg) sebanyak 13 pasien, dan kelompok B (Ibuprofen 800 mg) 13 pasien yang menjalani prosedur bedah dekompresi dan stabilisasi posterior dengan anestesi umum. Berdasarkan jenis dan bentuk data yang didapatkan kemudian ditentukan metode uji statistik untuk analisa derajat nyeri dan kebutuhan opioid fentanyl menggunakan uji t-group dengan menggunakan SPSS 23. Hasil dinilai bermakna jika nilai p <0.05. Data ditampilakn dalam bentuk frekuensi (n) dan presentase diuji dengan Mann-Whitney. Variable numerik disajikan dalam bentuk rerata ± simpang baku (mean±SD) dan diuji dengan Uji t-group (uji parametrik) jika memenuhi syarat (distribusi normal, varian sama). Hasil: Ditemukan perbedaan yang bermakna NRS diam dan NRS gerak pada waktu pengukuran 2 jam, 6 jam, 12 jam, dan 24 jam pascabedah antara kelompok ibuprofen 800 mg kombinasi dexametasone 10 mg dan ibuprofen 800 mg (p<0,05). Ibuprofen 800 mg kombinasi dexamethasone 10 menurunkan penggunaan opioid fentanyl 59 % dibandingkan kelompok ibuprofen 800 mg. Diskusi: Ibuprofen 800 mg intravena kombinasi dexamethasone 10 mg dapat menurunkan NRS diam dan gerak pada pembedahan dekompresi dan stabilisasi posterior tulang belakang, sesuai dengan temuan pada penelitian-penelitian sebelumnya. Kesimpulan: Preventif analgesia ibuprofen 800 mg kombinasi dexamethasone 10 mg menurunkan intensitas nyeri pada pasien pascabedah dekompresi dan stabilisasi posterior tulang belakang.

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Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury

Cited by 15 publications

References 49 publications

Comparison of Pain Control and Inflammatory Profile in Cesarean Section Patients Treated with Multimodal Analgesia Utilizing Paracetamol and Ibuprofen

Comparison of Pain Control and Inflammatory Profile in Cesarean Section Patients Treated with Multimodal Analgesia Utilizing Paracetamol and Ibuprofen

Blood Procalcitonin Level as a Diagnostic Marker of Pediatric Bacterial Meningitis: A Systematic Review and Meta-Analysis

Perbandingan Preventif Analgesia Ibuprofen 800 Mg Kombinasi Dexamethasone 10 Mg Intravena Terhadap Intensitas Nyeri Pascabedah Dekompresi Dan Stabilisasi Posterior

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