Ibuprofen versus other non‐steroidal anti‐inflammatory drugs: use in general practice and patient perception

Hawkey,; Cullen,; Pearson,; Holmes,; Doherty, Michael; Wilson, Rachel; Garrud,; Garner,; Maynard,; Logan,

doi:10.1046/j.1365-2036.2000.00699.x

Cited by 17 publications

(4 citation statements)

References 3 publications

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“…The scoring percentages, of the periapical inflammatory infiltrate by the scoring system that are listed in table 4, denote that, after 1 month of treatment, groups containing IBU (GP2, GP4, and GP5) showed significantly favorable inflammation responses compared to that for the positive control groups (p > 0.05). Such results reveal the role of the anti-inflammatory drug in treating inflammation in the peripheral lesions as IBU is known to reduce inflammation by inhibiting various enzymes and preventing the formation of some types of prostaglandins [41]. After 3 months, GP3, GP4, and Table 3.…”

Section: Groupmentioning

confidence: 81%

Injectable nanoamorphous calcium phosphate based in situ gel systems for the treatment of periapical lesions

et al. 2015

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Nonsurgical local treatment of a periapical lesion arising from trauma or bacterial infection is a promising innovative approach. The present study investigated the feasibility of developing injectable amorphous calcium phosphate nanoparticles (ACP NPs) and ACP NPs loaded with an anti-inflammatory drug; ibuprofen (IBU-ACP NPs) in the form of thermoreversible in situ gels to treat periapical lesions with the stimulation of bone formation. NPs were produced by a spray-drying technique. Different formulations of Poloxamer 407 were incorporated with/without the produced NPs to form injectable gels. A drug release study was carried out. A 3 month in vivo test on a dog model also was assessed. Results showed successful incorporation of the drug into the NPs of CP during spray drying. The particles had mean diameters varying from 100 to 200 nm with a narrow distribution. A drug release study demonstrated controlled IBU release from IBU-ACP NPs at a pH of 7.4 over 24 h. The gelation temperature of the injectable in situ gels based on Poloxamer 407 was measured to be 30 °C. After 3 months of implantation in dogs, the results clearly demonstrated that the inclusion of ACP NPs loaded with IBU showed high degrees of periapical bone healing and cementum layer deposition around the apical root tip.

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Section: Groupmentioning

confidence: 81%

Injectable nanoamorphous calcium phosphate based in situ gel systems for the treatment of periapical lesions

et al. 2015

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“…While DCF is better tolerated than nonselective NSAIDs such as indomethacin, it is still associated with a variety of toxic small intestinal side effects. 30,31 A typical therapeutic dose of DCF (50 mg orally) translates into local concentrations between 300 and 1600 μM of DCF within the intestinal lumen (assuming an intestinal fluid volume of between 0.1 and 0.5 L). 32 Therefore, we employed a range of DCF between 500 and 1000 μM to recapitulate an intraluminal physiologically relevant concentration.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Diclofenac (2-(2,6-dichloroanilino) phenylacetic acid; DCF) has an approximately 10-fold higher preference for the COX-2 isoenzyme versus COX-1 and is primarily ingested orally, although it may also be administered via topical, intravenous, intramuscular, and intrarectal routes. While DCF is better tolerated than nonselective NSAIDs such as indomethacin, it is still associated with a variety of toxic small intestinal side effects. , A typical therapeutic dose of DCF (50 mg orally) translates into local concentrations between 300 and 1600 μM of DCF within the intestinal lumen (assuming an intestinal fluid volume of between 0.1 and 0.5 L) . Therefore, we employed a range of DCF between 500 and 1000 μM to recapitulate an intraluminal physiologically relevant concentration.…”

Section: Results and Discussionmentioning

confidence: 99%

Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

et al. 2017

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The intestinal epithelium provides a critical barrier that separates the gut microbiota from host tissues. Nonsteroidal anti-inflammatory drugs (NSAIDs) are efficacious analgesics and antipyretics and are among the most frequently used drugs worldwide. In addition to gastric damage, NSAIDs are toxic to the intestinal epithelium, causing erosions, perforations, and longitudinal ulcers in the gut. Here, we use a unique in vitro human primary small intestinal cell monolayer system to pinpoint the intestinal consequences of NSAID treatment. We found that physiologically relevant doses of the NSAID diclofenac (DCF) are cytotoxic because they uncouple mitochondrial oxidative phosphorylation and generate reactive oxygen species. We also find that DCF induces intestinal barrier permeability, facilitating the translocation of compounds from the luminal to the basolateral side of the intestinal epithelium. The results we outline here establish the utility of this novel platform, representative of the human small intestinal epithelium, to understand NSAID toxicity, which can be applied to study multiple aspects of gut barrier function including defense against infectious pathogens and host-microbiota interactions.

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“…Questionnaire-based study conducted in UK general medical practices which compared prescribed NSAIDs and described by patients reported mean (s.d.) compliance (percentage of intended dose taken) of 0.73 (0.55) for ibuprofen, 0.76 (0.56) for diclofenac and 0.76 (0.55) for Naproxen ( Hawkey et al , 2000 ). It is unlikely, however, that non-adherence would differ systematically between cases and controls in our study.…”

Section: Discussionmentioning

confidence: 99%

Aspirin and non-steroidal anti-inflammatory drug use and the risk of upper aerodigestive tract cancer

2014

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Background:Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and preventative agents for vascular events. It is unclear whether their long-term use affects cancer risk. Data on the chemopreventative role of these drugs on the risk of the upper aerodigestive tract cancer (UADT) are insufficient and mostly refer to oesophageal cancer. The aim of this study was to investigate the effect of aspirin and other NSAIDs on the risk of UADT cancers.Methods:A nested case–control study using the Primary Care Clinical Informatics Unit (PCCIU) database. Conditional logistics regression was used for data analysis.Results:There were 2392 cases of UADT cancer diagnosed between 1996 and 2010 and 7165 age-, gender- and medical practice-matched controls from 131 general medical practices. Mean age of cases was 66 years (s.d. 12) and most were male (63%). Aspirin was prescribed in a quarter of cases and controls, COX-2 inhibitors in 4% of cases and 5% of controls and other NSAIDs in 33% of cases and 36% of controls. Aspirin prescription was associated with a nonsignificant risk reduction of cancer of UADT (adjusted OR=0.9, 95% CI=0.8, 1.0), head and neck (HN; adjusted OR=0.9, 95% CI=0.7, 1.1) or the oesophagus (adjusted OR=0.8, 95% CI=0.7, 1.0). Similar results were found for COX-2 inhibitors prescription. Prescription of other NSAIDs was associated with significantly reduced risk of cancer of UADT (adjusted OR=0.8, 95% CI=0.7, 0.9), HN (adjusted OR=0.8, 95% CI=0.7, 0.9) and the oesophagus (adjusted OR=0.8, 95% CI=0.7, 0.9). An increased volume of aspirin prescriptions was associated with a significant risk reduction (test for trend P<0.001).Conclusions:The decreased risk of cancer of the UADT associated with the use of non-COX-2 inhibitors, NSAIDs and long-term aspirin therapy warrants further exploration of the benefits vs risks of the use of these agents.

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Ibuprofen versus other non‐steroidal anti‐inflammatory drugs: use in general practice and patient perception

Abstract: Ibuprofen is as highly regarded as other NSAIDs when used in similar circumstances. Switching patients to ibuprofen may be a realistic way of reducing financial and medical costs associated with NSAIDs.

Cited by 17 publications

References 3 publications

Injectable nanoamorphous calcium phosphate based in situ gel systems for the treatment of periapical lesions

Injectable nanoamorphous calcium phosphate based in situ gel systems for the treatment of periapical lesions

Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

Aspirin and non-steroidal anti-inflammatory drug use and the risk of upper aerodigestive tract cancer

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