Ibutilide added to propafenone for the conversion of atrial fibrillation and atrial flutter

Chiladakis, John; Καλογερόπουλος, Ανδρέας; Patsouras, Nikolaos; Manolis, Antonis S.

doi:10.1016/j.jacc.2004.04.056

Cited by 34 publications

(19 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study was also planned to assess safety (including adverse events [AEs], electrocardiogram [ECG] variables, and significant arrhythmias) and to investigate the relationship between AZD7009 plasma concentration and QT/QTc interval. Safety analyses continued up to the second (final) follow-up visit (day [8][9][10][11][12][13][14][15].…”

Section: Methodsmentioning

confidence: 99%

“…At the second follow-up visit (day [8][9][10][11][12][13][14][15], the observation was made that the proportion of patients remaining in SR following pharmacological conversion was similar to the proportion remaining in SR after DC cardioversion (63% vs 65%, overall). Irrespective of cardioversion method, a greater proportion of patients treated with AZD7009 were still in SR at the second follow-up visit than patients treated with placebo (64% vs 55%, overall).…”

Section: Efficacymentioning

confidence: 99%

See 1 more Smart Citation

Rapid Conversion of Persistent Atrial Fibrillation to Sinus Rhythm by Intravenous AZD7009

Geller¹,

Egstrup²,

Kułakowski³

et al. 2009

The Journal of Clinical Pharma

View full text Add to dashboard Cite

This randomized, double-blind trial compared cardioversion rates between AZD7009 infusion (15-minute 3.25 mg/min, 15-minute 4.4 mg/min, or 30-minute 3.25 mg/min) and placebo infusion (15 or 30 minutes) in patients with atrial fibrillation (AF) scheduled for DC cardioversion. One hundred sixty-eight patients were randomized, 167 received study treatment, and 159 were included in perprotocol analyses. The mean duration of current AF episode was 47 days (range, 0.8-92). In the AZD7009 30-minute 3.25 mg/min group, 21 of 42 patients converted within 90 minutes, compared with 7 of 39, 7 of 36, and 0 of 42 patients in the 15-minute 3.25 mg/min, 15-minute 4.4 mg/min, and combined placebo groups, respectively. Patients not converted within 90 minutes underwent DC cardioversion. In patients with AF episodes

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Efficacymentioning

confidence: 99%

Rapid Conversion of Persistent Atrial Fibrillation to Sinus Rhythm by Intravenous AZD7009

Geller¹,

Egstrup²,

Kułakowski³

et al. 2009

The Journal of Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Elderly pacemaker recipients for AV block may have an additional reason to be at risk because the asynchronous ventricular contraction imposed by RV pacing has been associated with unfavorable structural and functional alterations, deleterious hemodynamics, and increased risk of heart failure [2,3,4, 15, 16]. Therefore, early screening of these patients is of particular importance to aid preventive measures and early disease management, since symptom-less LV diastolic abnormalities often precede systolic dysfunction and are thus often concealed from the patient and the physician [5,6,7].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effects of Atrial Synchronous Ventricular Pacing on Systolic and Diastolic Ventricular Function in Patients with Normal Left Ventricular Ejection Fraction

Chiladakis

Koutsogiannis²,

Καλογερόπουλος³

et al. 2007

Cardiology

Self Cite

View full text Add to dashboard Cite

Background: Atrial synchronous right ventricular pacing (VP) may compromise ventricular function in patients undergoing pacemaker implantation for atrioventricular block. We assessed the usefulness of tissue Doppler imaging (TDI) and color M-mode echocardiography in evaluating patients with VP, and examined the long-term effects of VP on ventricular function by echocardiographic indices and B-type natriuretic peptide (BNP) measurements. Methods: We studied 60 clinically stable elderly dual-chamber pacemaker recipients (mean age: 74 ± 9 years) who had normal left ventricular (LV) systolic function and on the long term the same cardiac rhythm, either intrinsic normal ventricular activation (IA) (n = 20), or VP (n = 40). Results: Paced patients, compared to patients with IA, had decreased stroke volume (p < 0.05) and a more depressed relaxation pattern, as indicated by decreased peak early mitral velocity (E)/peak atrial contraction velocity ratio and tissue Doppler imaging (TDI)-early transmitral diastolic velocity (Ea) measures (p < 0.05). Both groups presented similar BNP levels and LV filling pressures, as assessed by E/Ea and E/early diastolic transmitral flow propagation velocity. In VP patients, age (β = 0.31), Ea (β = –0.28) and E/Ea (β = 0.32) emerged as independent predictors of BNP levels. Conclusions: VP is associated with reduced LV systolic function and signs of impaired relaxation. Elevated BNP levels in elderly VP patients with normal ejection fraction may be predicted by TDI signs of LV diastolic dysfunction.

show abstract

“…Due to this risk of torsades, initiation of this drug requires a mandatory inpatient loading period for 3 days with titration of the dose based upon QT interval and renal function. Ibutilide, another class III antiarrhythmic available in an intravenous form, is used mostly for acute conversion to sinus rhythm and is not used as maintenance therapy to prevent AF recurrence 50–52…”

Section: Therapeutic Options In Afmentioning

confidence: 99%

Avoiding permanent atrial fibrillation: treatment approaches to prevent disease progression

Shukla¹,

Curtis²

2013

VHRM

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common sustained arrhythmia and a major global public health problem due to its associated morbidity, including stroke and heart failure, diminished quality of life, and increased mortality. AF often presents initially in a paroxysmal form and may progress to a more sustained form over time. Evidence from randomized controlled trials suggests that there may be no mortality benefit to using a rhythm control approach in comparison with rate control of AF. Nevertheless, sustained forms of AF may be associated with increased symptoms and cardiovascular morbidity, and consequently they remain an additional target for therapy. The present review evaluates the clinical correlates of arrhythmia progression and risk stratification techniques available to assess probability of AF progression. Further, currently available management options for arrhythmia control in AF are evaluated and their therapeutic effect and efficacy on disease progression are explored.

show abstract

Ibutilide added to propafenone for the conversion of atrial fibrillation and atrial flutter

Cited by 34 publications

References 17 publications

Rapid Conversion of Persistent Atrial Fibrillation to Sinus Rhythm by Intravenous AZD7009

Rapid Conversion of Persistent Atrial Fibrillation to Sinus Rhythm by Intravenous AZD7009

Long-Term Effects of Atrial Synchronous Ventricular Pacing on Systolic and Diastolic Ventricular Function in Patients with Normal Left Ventricular Ejection Fraction

Avoiding permanent atrial fibrillation: treatment approaches to prevent disease progression

Contact Info

Product

Resources

About