IC–P–124: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain

Abstract

ventricular volume, using two measures: the bicaudate ratio and the biatrial ratio, measured in most cases at two levels which were then averaged. Results: Bicaudate and biatrial ratios (meanϮSD, range) were 0.160Ϯ0.038 (0.07-0.26) and 0.242Ϯ056 (0.10-0.37). Average decline in mMMS was 3.46 points/year. Using GEE analysis, we found a significant relationship between bicaudate (pϽ0.001) and biatrial (p ϭ 0.007) atrophy scores and the rate of cognitive decline. Decline in mMMS was 0.41 (bicaudate) and 0.19 (biatrial) mMMS points/percentage point of atrophy /year, or about 14% and 18% increased speeds of decline per percentage point of atrophy. These relationships remained significant, even with adjustments for baseline mMMS, age, sex, education, cardiovascular risk factors, and apoE4. Conclusions: Brain atrophy is associated with increased rapidity of cognitive decline in AD. This association does not appear to relate to disease severity at baseline, nor apoE, age, or cardiovascular risk factors. AD may progress at different rates in different individuals.