ICAM gene cluster SNPs and prostate cancer risk in African Americans

Chen, Hankui; Hernandez, Wenndy; Shriver, Mark D.; Ahaghotu, Chiledum; Kittles, Rick A.

doi:10.1007/s00439-006-0184-3

Cited by 29 publications

(28 citation statements)

References 36 publications

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“…An additional integration site of interest is in 6q21, a frequently deleted region in prostate cancer (29). Two other integration sites, one each located in 11q13.4 and 19p13.2, are also in regions where high rates of chromosomal alterations have been observed in breast and prostate cancers (19,20,44).…”

Section: Discussionmentioning

confidence: 99%

Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer

Kim¹,

Kim

Dong³

et al. 2008

J Virol

117

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Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus identified inprostate cancer tissue from patients homozygous for a reduced-activity variant of the antiviral enzyme RNase L. Neither a casual relationship between XMRV infection and prostate cancer nor a mechanism of tumorigenesis has been established. To determine the integration site preferences of XMRV and the potential risk of proviral insertional mutagenesis, we carried out a genome-wide analysis of viral integration sites in the prostate cell line DU145 after an acute XMRV infection and compared the integration site pattern of XMRV with those found for murine leukemia virus and two human retroviruses, human immunodeficiency virus type 1 and human T-cell leukemia virus type 1. Among all retroviruses analyzed, XMRV has the strongest preference for transcription start sites, CpG islands, DNase-hypersensitive sites, and gene-dense regions; all are features frequently associated with structurally open transcription regulatory regions of a chromosome. Analyses of XMRV integration sites in tissues from prostate cancer patients found a similar preference for the aforementioned chromosomal features. Additionally, XMRV integration sites in cancer tissues were associated with cancer breakpoints, common fragile sites, microRNA, and cancer-related genes, suggesting a selection process that favors certain chromosomal integration sites. In both acutely infected cells and cancer tissues, no common integration site was detected within or near proto-oncogenes or tumor suppressor genes. These results are consistent with a model in which XMRV may contribute to tumorigenicity via a paracrine mechanism.Prostate cancer is the most common noncutaneous cancer diagnosed in men in developed countries and is responsible for the deaths of approximately 30,000 men per year in the United States (43). Despite its impact on male health, the molecular mechanisms involved in the pathogenesis of prostate cancer, particularly the events contributing to initiation and progression, remain relatively unknown in comparison with those for other common cancers. Epidemiological studies of kindreds with hereditary prostate cancer, who often display early-onset disease and account for 9% of all cases (16), identified HPC1 as a susceptibility locus for prostate cancer (94). HPC1 is linked to RNASEL, which encodes a regulated endoribonuclease for single-stranded RNA and functions in the antiviral action of interferon (IFN) (15, 17). In response to stimulation by viral double-stranded RNA, IFN treatment of cells induces a family of 2Ј-5Ј oligoadenylate synthetases that produce 2Ј-5Ј-linked oligoadenylates, which then activate the latent and ubiquitous protein RNase L, resulting in degradation of viral and cellular RNA and apoptosis induction (112). Several germ line variants of HPC1 and RNASEL have been observed in hereditary prostate cancer (91), including a common (35% allelic frequency) missense variant of RNase L in which a G-to-A transition at nucleotide position 13...

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Section: Discussionmentioning

confidence: 99%

Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer

Kim¹,

Kim

Dong³

et al. 2008

J Virol

117

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“…The expression of LFA-1 in breast cancer cell line can result in the transendothelial migration of breast cancer cells [14]. In addition, recent research has shown that ICAM-1 is a candidate gene associated with the risk of cancer [15][16][17][18], especially in breast cancer [19][20][21]. Thus, we supposed that LFA-1 polymorphisms might be also related to the risk of cancer.…”

Section: Discussionmentioning

confidence: 95%

LFA-1 gene polymorphisms are associated with the sporadic infiltrative duct breast carcinoma in Chinese Han women of Heilongjiang Province

Jiao

Zhang

et al. 2010

Breast Cancer Res Treat

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The infiltrative duct carcinoma (IDC) is the most common malignant breast cancer in females and genetic factors appear to play a significant role in the susceptibility of IDC. The LFA-1 is a crucial co-stimulatory molecule in immune system and may affect the development of breast IDC. In order to clarify the association of LFA-1 polymorphisms with IDC, a case-control study was conducted in women from Heilongjiang Province, Northeast of China. We scrutinized four genetic polymorphisms in LFA-1 gene, which may influence the activity and function of LFA-1. Our research subjects consist of 537 cases with IDC and 577 age-matched healthy controls. Genotypes were determined by PCR-RFLP. Data were analyzed using the χ(2) test by SPSS 13.0 and Haploview 4.1 softwares. The association between LFA-1 polymorphisms and the clinical features of IDC was analyzed. In rs2230433, the frequency of GG genotype and G allele was lower in cases than in controls (P = 0.0316 and 0.0480). And rs2230433, CG genotype was higher in cases (P = 0.0397). In rs8058823, the frequency of AA genotype and A allele was lower in cases than in controls (P = 0.00000418 and 0.00000267). And rs8058823, AG genotype was higher in cases (P = 0.00000747). The frequency of haplotype CCGA was lower in patients. Significant association was shown between the four SNPs of LFA-1 gene and estrogen receptor (ER), progesterone receptor (PR), C-erbB-2, and P53 statuses. In addition, no association was found between LFA-1 gene polymorphisms and tumor size, and neither was it between LFA-1 gene polymorphisms and lymph node metastasis. Our results primarily suggested that LFA-1 gene polymorphisms may predict the sporadic breast IDC risk and prognosis factors in Chinese Han women in Heilongjiang Province.

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“…The human ICAM-5 gene is composed of 11 exons encoding the signal peptide, each of the nine extracellular domains, and with a single exon encoding both the transmembrane and the cytoplasmic domains [46]. Chen et al [47] reported that there exist V301I and T348A polymorphisms in the gene. Allele frequencies differed in African Americans from published frequencies for Europeans.…”

Section: Structure Of Icam-5mentioning

confidence: 99%

Structure, Expression, and Function of ICAM-5

Yang

2012

Comparative and Functional Genomics

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Cell adhesion is of utmost importance in normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin, TLN) is a member of the ICAM family of adhesion proteins. As a novel cell adhesion molecule, ICAM-5 shares many structural similarities with the other members of IgSF, especially the ICAM subgroup; however, ICAM-5 has several unique properties compared to the other ICAMs. With its nine extracellular Ig domains, ICAM-5 is the largest member of ICAM subgroup identified so far. Therefore, it is much more complex than the other ICAMs. The expression of ICAM-5 is confined to the telencephalic neurons of the central nervous system whereas all the other ICAM members are expressed mostly by cells in the immune and blood systems. The developmental appearance of ICAM-5 parallels the time of dendritic elongation and branching, and synapse formation in the telencephalon. As a somatodendrite-specific adhesion molecule, ICAM-5 not only participates in immune-nervous system interactions, it could also participate in neuronal activity, Dendrites' targeting signals, and cognition. It would not be surprising if future investigations reveal more binding partners and other related functions of ICAM-5.

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ICAM gene cluster SNPs and prostate cancer risk in African Americans

Cited by 29 publications

References 36 publications

Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer

Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer

LFA-1 gene polymorphisms are associated with the sporadic infiltrative duct breast carcinoma in Chinese Han women of Heilongjiang Province

Structure, Expression, and Function of ICAM-5

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