Icariin Alleviates Bisphenol A Induced Disruption of Intestinal Epithelial Barrier by Maintaining Redox Homeostasis <i>In Vivo</i> and <i>In Vitro</i>

Zhu, Kun Yan; Yang, Yang; Bai, Yuansong; Zhao, Tianyu

doi:10.1021/acsomega.0c02364

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…The flavonoid icariin alleviated BPA-induced disrupted intestinal barrier function in mice [700]. Probiotics almost eliminated the metabolic toxicity of a mixture of phthalates and BPA in rats [701].…”

Section: Intervention and Prevention Strategiesmentioning

confidence: 98%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

117

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Section: Intervention and Prevention Strategiesmentioning

confidence: 98%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

117

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“…Icariin significantly alleviated atherogenesis by reducing the protein levels of protein kinase C βI and phosphorylated protein kinase C βI (Zhang, Xu, et al, 2021). Icariin has a certain intestinal protective effect, which is mainly reflected in alleviating the intestinal barrier function damage induced by bisphenol A (Zhu et al, 2020).…”

Section: Flavonoidsmentioning

confidence: 99%

Virtual screening analysis of natural flavonoids as trimethylamine ( TMA )‐lyase inhibitors for coronary heart disease

Zhou

Zhao

et al. 2022

Journal of Food Biochemistry

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Coronary heart disease (CHD) is defined by atherosclerosis, which can result in stenosis or blockage of the arterial cavity, leading to ischemic cardiac diseases such as angina and myocardial infarction. Accumulating evidence indicates that the gut microbiota plays a vital role in the beginning and progression of CHD. The gut microbial metabolite, trimethylamine‐N‐oxide (TMAO), is intimately linked to the pathophysiology of CHD. TMAO is formed when trimethylamine (TMA) is converted by flavin‐containing monooxygenases in the hepatocytes. Therefore, inhibition of TMA production is essential to reduce TMAO levels. Flavonoids may reduce the risk of death from cardiovascular disease. In this article, we reviewed and evaluated twenty‐two flavonoids for the therapy of CHD based on their inhibition of TMA‐lyase by molecular docking. Docking results revealed that baicalein, fisetin, acacetin, and myricetin in flavonoid aglycones, and baicalin, naringin, and hesperidin in flavonoid glycosides had a good binding effect with TMA‐lyase. This indicates that these chemicals were the most active and could be used as lead compounds for structural modification in the future. Practical applications Flavonoids are a large class of polyphenolic compounds found in fruits, vegetables, flowers, tea, and herbal medicines, which are inexorably metabolized and transformed into bioactive metabolites by α‐rhamnosidase, β‐glucuronidase, β‐glucosidase, and nitroreductase produced by the gut microbiota, which plays a beneficial role in the prevention and treatment of cardiovascular diseases. Because flavonoids protect the cardiovascular system and regulate the gut microbiota, and the gut microbiota is directly connected to TMAO, thus, reducing TMAO levels involves blocking the transition of TMA to TMAO, which may be performed by reducing TMA synthesis. Molecular docking results found that baicalein, fisetin, acacetin, and myricetin in flavonoid aglycones, and baicalin, naringin, and hesperidin in flavonoid glycosides had good binding effects on TMA‐lyase, which were the most active and could be used as lead compounds for structural modification.

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“…ELISA kits were used to test the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), reactive oxygen species (ROS), reactive nitrogen species (RNS), and hydrogen peroxide (H 2 O 2 ) in plasma, as previously described [68]. The manufacturer's manuals provided specific instructions for the test procedure.…”

Section: Assessment Of Plasma Parametersmentioning

confidence: 99%

Exposure to Atrazine Induces Lung Inflammation through Nrf2-HO1 andBeclin 1/LC3 Pathways

D’Amico

Monaco

Fusco

et al. 2021

Cell Physiol Biochem

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BACKGROUND/AIMS: Atrazine (ATR) is the second most widely used herbicide, after glyphosate, that is used to stop pre- and post-emergence broadleaf and grassy weeds. In 2007, it was included in the class of endocrine disruptors due to the impact its exposure had on human health. Occasional ATR exposure at work has been linked to an increased risk of respiratory problems, but the molecular mechanisms underlying this relationship has not yet been fully elucidated. METHODS: Mice were exposed to an aerosol containing ATR. In particular ATR aerosol was prepared by dissolving 250 mg of ATR in a vehicle made with saline and 10% DMSO. Seven days after the aerosol exposure, the mice were sacrificed and lung tissue, bronchoalveolar lavage fluid (BALF), and blood samples were collected for histology and biochemical analysis. RESULTS: ATR inhalation induces a generalized state of oxidative/nitrosative stress that leads to an increase in cytokines production and to a physiologically unstable antioxidant defense response evaluated by the alteration of Nrf-2 pathways. Moreover, it stimulates autophagy through Beclin 1/Lc3 expressions and increases lipid peroxidation and apoptosis. All these effects culminate in serious alterations in the tissue architecture of the lungs and to an increase in mucus production and mast cells degranulation. CONCLUSION: Our study shows, for the first time, the impact of ATR inhalation on lung tissue. This could represent the first step to also recognize this substance as a problematic air pollutant as well as a soil and water contaminant.

show abstract

Icariin Alleviates Bisphenol A Induced Disruption of Intestinal Epithelial Barrier by Maintaining Redox Homeostasis In Vivo and In Vitro

Cited by 6 publications

References 49 publications

Obesity II: Establishing causal links between chemical exposures and obesity

Obesity II: Establishing causal links between chemical exposures and obesity

Virtual screening analysis of natural flavonoids as trimethylamine ( TMA )‐lyase inhibitors for coronary heart disease

Exposure to Atrazine Induces Lung Inflammation through Nrf2-HO1 andBeclin 1/LC3 Pathways

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