Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats

Aljehani, Abeer A.; Albadr, Nawal A.; Nasrullah, Mohammed Z.; Neamatallah, Thikryat; Eid, Basma G.; Abdel-Naim, Ashraf B.

doi:10.1007/s11356-021-17245-4

Cited by 11 publications

(7 citation statements)

References 53 publications

(31 reference statements)

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“…Additionally, the CB1 receptor has been reported to activate the Wnt/β-catenin pathway, which regulates cell cycle progression and proliferation in cancer cells. Inhibition of Wnt/β-catenin pathway by rimonabant was reported in colorectal cancer cells, leading to cell cycle arrest [ 42 ]. Therefore, peripheral targeting of CB1 by AM6545 and AM4113 is a promising therapeutic strategy in BPH treatment without the side effects associated with rimonabant that stems from the central CB1 blockade [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats

et al. 2023

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Metabolic syndrome (MetS) is a combination of metabolic disorders that can predispose individuals to benign prostatic hyperplasia (BPH). The inhibition of the cannabinoid 1 (CB1) receptor has been used to treat metabolic disorders in animal models. This study reports the use of a peripherally restricted CB1 antagonist (AM6545) and a neutral CB1 antagonist (AM4113) to improve MetS-related BPH in rats. Animals were divided into three control groups to receive either a normal rodent diet, AM6545, or AM4113. MetS was induced in the fourth, fifth, and sixth groups using a concentrated fructose solution and high-salt diet delivered as food pellets for eight weeks. The fifth and sixth groups were further given AM6545 or AM4113 for additional four weeks. Body and prostate weights were measured and prostate sections were stained with haematoxylin eosin. Cyclin D1, markers of oxidative stress and inflammation, and levels of the endocannabinoids were recorded. BPH in rats with MetS was confirmed through increased prostate weight and index, as well as histopathology. Treatment with either AM6545 or AM4113 significantly decreased prostate weight, improved prostate histology, and reduced cyclin D1 expression compared with the MetS group. Groups treated with CB1 antagonists experienced reduced lipid peroxidation, recovered glutathione depletion, restored catalase activity, and had lower inflammatory markers interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). MetS rats treated with either AM6545 or AM4113 showed reduced concentrations of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in the prostate compared with the MetS group. In conclusion, the CB1 antagonists AM6545 and AM4113 protect against MetS-induced BPH through their anti-proliferative, antioxidant, and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats

et al. 2023

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“…ICA protected against metabolic syndrome induced BPH in terms of decreased weight and index of the prostate and altered histopathology in a rat model. The underlying mechanisms included the antiproliferative, proapoptotic, antioxidant, and anti‐inflammatory activities of ICA 50 …”

Section: The Anti‐aging Effects Of Ica and Their Mechanismsmentioning

confidence: 99%

“…The underlying mechanisms included the antiproliferative, proapoptotic, antioxidant, and anti‐inflammatory activities of ICA. 50 …”

Section: The Anti‐aging Effects Of Ica and Their Mechanismsmentioning

confidence: 99%

Anti‐aging effects of icariin and the underlying mechanisms: A mini‐review

Li,

Wei,

2024

Aging Medicine

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Aging is an extremely intricate and progressive phenomenon that is implicated in many physiological and pathological conditions. Icariin (ICA) is the main active ingredient of Epimedium and has exhibited multiple bioactivities, such as anti‐tumor, neuroprotective, antioxidant, anti‐inflammatory, and anti‐aging properties. ICA could extend healthspan in both invertebrate and vertebrate models. In this review, the roles of ICA in protection from declined reproductive function, neurodegeneration, osteoporosis, aging intestinal microecology, and senescence of cardiovascular system will be summarized. Furthermore, the underlying mechanisms of ICA‐mediated anti‐aging effects will be introduced. Finally, we will discuss some key aspects that constrain the usage of ICA in clinical practice and the corresponding strategies to solve these issues.

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“…ICRN (C 33 H 40 O 15 , M w = 676.67) is a type of prenylated flavonoid, showing extensive bioactivities such as antioxidant [ 44 , 45 , 46 , 47 ], neuroprotective [ 48 , 49 , 50 , 51 , 52 ], and antitumor [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] behavior as well as anti-inflammatory responses [ 62 , 63 , 64 , 65 , 66 , 67 , 68 ], and can be used to treat erectile dysfunction [ 69 , 70 , 71 , 72 ]. It appears it can improve the function of organs including bones and the heart [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ].…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

Seyedi¹,

Amiri

Mohammadzadeh

et al. 2023

JFB

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Among scaffolds used in tissue engineering, natural biomaterials such as plant-based materials show a crucial role in cellular function due to their biocompatibility and chemical indicators. Because of environmentally friendly behavior and safety, green methods are so important in designing scaffolds. A key bioactive flavonoid of the Epimedium plant, Icariin (ICRN), has a broad range of applications in improving scaffolds as a constant and non-immunogenic material, and in stimulating the cell growth, differentiation of chondrocytes as well as differentiation of embryonic stem cells towards cardiomyocytes. Moreover, fusion of ICRN into the hydrogel scaffolds or chemical crosslinking can enhance the secretion of the collagen matrix and proteoglycan in bone and cartilage tissue engineering. To scrutinize, in various types of cancer cells, ICRN plays a decisive role through increasing cytochrome c secretion, Bax/Bcl2 ratio, poly (ADP-ribose) polymerase as well as caspase stimulations. Surprisingly, ICRN can induce apoptosis, reduce viability and inhibit proliferation of cancer cells, and repress tumorigenesis as well as metastasis. Moreover, cancer cells no longer grow by halting the cell cycle at two checkpoints, G0/G1 and G2/M, through the inhibition of NF-κB by ICRN. Besides, improving nephrotoxicity occurring due to cisplatin and inhibiting multidrug resistance are the other applications of this biomaterial.

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Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats

Cited by 11 publications

References 53 publications

Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats

Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats

Anti‐aging effects of icariin and the underlying mechanisms: A mini‐review

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

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