Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Wang, Shuangqiu; Ma, Jiarui; Zeng, Yanqi; Zhou, Guowei; Wang, Yuxuan; Zhou, Wenjuan; Sun, Xiaohe; Wu, Minghua

doi:10.2147/dddt.s310686

Cited by 42 publications

(24 citation statements)

References 206 publications

(264 reference statements)

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“…Finally, network pharmacology has been used to understand the relationships between drugs and organisms from the perspective of system networks. The results revealed that the therapeutic impact of ICA on AD may be implicated in a variety of signaling pathways including the PI3K-Akt signaling pathway, sphingolipid signaling pathway and NF-κB signaling pathway, consistent with previous studies [39]. In ovarian cancer, ICA has been proved to have a therapeutic effect via the PI3K-Akt signaling pathway and the NF-κB signaling pathway [40].…”

Section: Discussionsupporting

confidence: 89%

Anti-Alzheimers molecular mechanism of icariin: Insights from gut microbiota and metabolome combined network pharmacology

Liu

Wang

et al. 2023

Preprint

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Background Icariin (ICA), an active ingredient extracted from a natural plant called Epimedii, has shown a broad application prospect in the treatment of Alzheimer's disease (AD). Nevertheless, its potential therapeutic mechanism remains largely unknown.The present study aims to investigate the therapeutic effect and the underlying mechanism of ICA on AD by an integrated analysis of gut microbiota and metabolomics. Methods The cognitive impairment of mice was measured using the Morris Water Maze. Hematoxylin and eosin staining was used to identify the AD-induced pathologic change. 16S rRNA sequencing and multi-metabolomics were performed to analyze the alterations in microbiota and serum/fecal metabolism. Results Our results demonstrated that ICA intervention could markedly improve cognitive dysfunction in APP/PS1 mice and typical AD pathologies in the hippocampus of APP/PS1 mice. Gut microbiota analysis showed that ICA administration could reverse the imbalance of gut microbes in APP/PS1 mice by elevating the proportion of Akkermansia and reducing the proportion of Alistipe. Metabolomic analysis revealed AD-induced metabolic disorder was improved by ICA via glycerophospholipid metabolism and sphingolipid metabolism. Correlation analysis suggested that these were closely related to the abundance of Alistipe and Akkermansia. Conclusion These findings indicated that ICA may serve as a promising therapeutic approach for AD, and that the ICA-mediated protective effects were associated with the amelioration of microbiota disturbance and metabolic disorder.

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Section: Discussionsupporting

confidence: 89%

Anti-Alzheimers molecular mechanism of icariin: Insights from gut microbiota and metabolome combined network pharmacology

Liu

Wang

et al. 2023

Preprint

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“…(1) Icariin: Icariin is the main active ingredient of Epimedii folium , which is an 8-prenyl flavonoid glycoside compound ( 281 ). Icariin can increase cardiovascular and cerebrovascular blood flow, inhibit inflammation, resist oxidative stress, regulate immunity, promote hematopoietic function, immune function and bone metabolism, and also has the effects of tonifying kidney and strengthening yang, anti-aging and so on ( 282 – 284 ). Tang et al.…”

Section: Modulatory Effects Of Natural Botanical Components On Microg...mentioning

confidence: 99%

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

et al. 2023

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Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms of IS. In particular, the early proinflammatory response resulting from the overactivation of resident microglia and the infiltration of circulating monocytes and macrophages in the brain after cerebral ischemia leads to secondary brain injury. Microglia are innate immune cells in the brain that constantly monitor the brain microenvironment under normal conditions. Once ischemia occurs, microglia are activated to produce dual effects of neurotoxicity and neuroprotection, and the balance of the two effects determines the fate of damaged neurons. The activation of microglia is defined as the classical activation (M1 type) or alternative activation (M2 type). M1 type microglia secrete pro-inflammatory cytokines and neurotoxic mediators to exacerbate neuronal damage, while M2 type microglia promote a repairing anti-inflammatory response. Fine regulation of M1/M2 microglial activation to minimize damage and maximize protection has important therapeutic value. This review focuses on the interaction between M1/M2 microglia and other immune cells involved in the regulation of IS phenotypic characteristics, and the mechanism of natural plant components regulating microglia after IS, providing novel candidate drugs for regulating microglial balance and IS drug development.

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“…This plant is abundantly found in different parts of Asia as well as Europe [74]. E. herba has been prescribed for over 2000 years in Eastern Asia countries by traditional Chinese medicine practitioners for its therapeutic functions [75]. Chronic disorders such as female sterility, chronic bronchitis, general edema, leucopenia, kidney disorders, viral myocarditis, and hypertension are among the most important conditions that E. herba can provide a beneficial alleviating role [74,75].…”

Section: Icariin a Novel Phytochemical With Favored Medicament Proper...mentioning

confidence: 99%

“…ginkgetin [77], quercetin [78], robinetin [75], apigenin [75], luteolin [79], hyperin [77], and icariin [80].…”

Section: Icariin a Novel Phytochemical With Favored Medicament Proper...mentioning

confidence: 99%

The Role of Nursing Care in the Management of Patients with Traumatic Subarachnoid Hemorrhage

Mousavi

Khastehband

Poudineh

et al. 2023

GMJ

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Ovarian cancer is described as one of the most common types of cancer and the leading cause of cancer-related deaths due to the high aggressiveness of this malignancy. However, the current therapeutically strategies failed to confront ovarian cancer or are accompanied by significant adverse effects leading to the recurrence of the disease and/or affecting the quality of life of survivors. On the other hand, ovarian cancer is recognized as a heterogenous disorder that is specified by alteration in a variety of molecular and cellular markers. Thereby, researchers are keen to find a novel therapeutical strategy representing high efficacy and safety, as well as be able to modulate altered biomolecules and signaling pathways. Icariin is a phytoestrogen with desired properties that are suggested for several chronic complications, particularly different types of cancer. The aim of the present study was to reveal the ameliorative characteristics of icariin and then discuss the antitumoral activities of this phytochemical against ovarian cancer with an emphasis on the modified molecular signaling pathways.

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Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Cited by 42 publications

References 206 publications

Anti-Alzheimers molecular mechanism of icariin: Insights from gut microbiota and metabolome combined network pharmacology

Anti-Alzheimers molecular mechanism of icariin: Insights from gut microbiota and metabolome combined network pharmacology

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

The Role of Nursing Care in the Management of Patients with Traumatic Subarachnoid Hemorrhage

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