Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation

Shen, Xiaofeng; Yu, Pengfei; Chen, Hua; Lu, Binjie; Cai, Xuefeng; Gu, Chaohao; Liang, Guoqiang; Hao, Donglin; Ma, Qihan; Li, Yuwei

doi:10.1039/d0ra00637h

Cited by 15 publications

(19 citation statements)

References 34 publications

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“…However, this claim can not be extended to the hydrogel nanocomposite construct including unbound icariin. Compared to the neat hydrogel, the presence of the MSNs in the hydrogel nanocomposites appears to stimulate cell proliferation, as already verified by other research groups [37,38]. Valerio et al [38] attributed the promoted osteoblast cell viability to the release of silicon ions from the MSNs.…”

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confidence: 57%

“…This could be attributed to an improved bioactivity of the hydrogel nanocomposites due to the surface immobilization of MSNs. MSNs are known to release ions in body fluids, thereby enhancing the generation of surface-active hydroxyl carbonate apatite (HCA) and stimulating genes that are involved in osteogenesis [37]. Such a property is enhanced when icariin is loaded onto the nanoparticles, and a synergistic effect of icariin, slowly released into the medium, and the bioactive nanoparticles is possible.…”

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confidence: 99%

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3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering

Monavari

Homaeigohar

Fuentes-Chandía

et al. 2021

Materials Science and Engineering: C

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confidence: 57%

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confidence: 99%

3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering

Monavari

Homaeigohar

Fuentes-Chandía

et al. 2021

Materials Science and Engineering: C

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“…In general, the ions released from MSNs into body fluid promote the formation of hydroxyl carbonate apatite (HCA) and excite the genes that contribute to osteogenesis. [ 74 ] After 21 days of cell culture, the Lys containing hydrogel nanocomposite appeared to be slightly more encouraging toward apatite formation than the enzyme‐free nanocomposite. This observation was confirmed quantitatively, as shown in Figure 8c.…”

Section: Resultsmentioning

confidence: 99%

A 3D Printed Bone Tissue Engineering Scaffold Composed of Alginate Dialdehyde‐Gelatine Reinforced by Lysozyme Loaded Cerium Doped Mesoporous Silica‐Calcia Nanoparticles

Monavari

Medhekar

Nawaz

et al. 2022

Macromolecular Bioscience

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A novel biomaterial comprising alginate dialdehyde-gelatine (ADA-GEL) hydrogel augmented by lysozyme loaded mesoporous cerium doped silica-calcia nanoparticles (Lys-Ce-MSNs) is 3D printed to create bioactive scaffolds. Lys-Ce-MSNs raise the mechanical stiffness of the hydrogel composite scaffold and induce surface apatite mineralization, when the scaffold is immersed in simulated body fluid (SBF). Moreover, the scaffolds can co-deliver bone healing (Ca and Si) and antioxidant ions (Ce), and Lys to achieve antibacterial (and potentially anticancer) properties. The nanocomposite hydrogel scaffolds can hold and deliver Lys steadily. Based on the in vitro results, the hydrogel nanocomposite containing Lys assured improved pre-osteoblast cell (MC3T3-E1) proliferation, adhesion, and differentiation, thanks to the biocompatibility of ADA-GEL, bioactivity of Ce-MSNs, and the stabilizing effect of Lys on the scaffold structure. On the other hand, the proliferation level of MG63 osteosarcoma cells decreased, likely due to the effect of Lys. Last but not least, cooperatively, alongside gentamicin (GEN), Lys brought about a proper antibacterial efficiency to the hydrogel nanocomposite scaffold against gram-positive and gram-negative bacteria. Taken together, ADA-GEL/Lys-Ce-MSN nanocomposite holds great promise for 3D printing of multifunctional hydrogel bone tissue engineering (BTE) scaffolds, able to induce bone regeneration, address infection, and potentially inhibit tumor formation and growth.

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“…Thus, during the fabrication process, part of the solution of silk fibroin can enter into the pores of mesoporous glass leading to a stronger bond with silk fibroin after freeze-drying [135]. Additionally, mesoporous glass/silk fibroin scaffolds showed a better apatite mineralization ability probably due to the faster dissolution rate [135,136]. The faster dissolution rate may give a favorable environment for cell adhesion and proliferation and for further tissue growth.…”

Section: Dip Coating Techniquementioning

confidence: 99%

A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

2020

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Collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose are biocompatible and non-cytotoxic, being attractive natural polymers for medical devices for both soft and hard tissues. However, such natural polymers have low bioactivity and poor mechanical properties, which limit their applications. To tackle these drawbacks, collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose can be combined with bioactive glass (BG) nanoparticles and microparticles to produce composites. The incorporation of BGs improves the mechanical properties of the final system as well as its bioactivity and regenerative potential. Indeed, several studies have demonstrated that polymer/BG composites may improve angiogenesis, neo-vascularization, cells adhesion, and proliferation. This review presents the state of the art and future perspectives of collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose matrices combined with BG particles to develop composites such as scaffolds, injectable fillers, membranes, hydrogels, and coatings. Emphasis is devoted to the biological potentialities of these hybrid systems, which look rather promising toward a wide spectrum of applications.

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Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation

Abstract: Long-term promotion of osteogenic differentiation through silk fibroin/mesoporous bioactive glass-loaded sustained release of icariin.

Cited by 15 publications

References 34 publications

3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering

3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering

A 3D Printed Bone Tissue Engineering Scaffold Composed of Alginate Dialdehyde‐Gelatine Reinforced by Lysozyme Loaded Cerium Doped Mesoporous Silica‐Calcia Nanoparticles

A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

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