Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice

Li, Xiaoang; Khan, Imran; Xia, Wenrui; Huang, Guoxin; Liu, Liang; Law, Betty Yuen Kwan; Yin, Li; Liao, Wei-Lin; Leong, Waikit; Han, Ruixuan; Wong, Vincent Kam Wai; Xia, Chenglai; Guo, Xiaoling; Hsiao, W.L. Wendy

doi:10.1016/j.phrs.2021.105587

Cited by 29 publications

(37 citation statements)

References 70 publications

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“…Icariin (ICA), a flavone compound extracted from Epicedium, shows a range of pharmacological functions, such as anti-oxidation, anti-inflammation and anti-aging effects both in vivo and in vitro, as multiple studies have concluded [ 17 ]. ICA has also been reported to inhibit LPS-induced inflammation in mouse peritoneal macrophages and peritonitis models [ 18 ]. Furthermore, ICA could reduce inflammatory penetration in neurological disorder models by passing the blood-brain barrier [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

Wang

et al. 2022

Redox Biology

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Section: Introductionmentioning

confidence: 99%

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

Wang

et al. 2022

Redox Biology

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“…Besides, mitigation of matrix metalloproteinases (MMP)-3 and -13 induced by TNF-α and IL-1β were displayed following treatment with baicalein [278]. Li et al (2021) showed that the administration of icariin (e ), a flavonol glycoside in aged rats, could enhance learning skills and motor coordination. Additionally, the attenuation of components of oxidative stress in numerous biofluids and organelles, and a decrease of pro-inflammatory cytokines and iNOS were exhibited, which also showed a correlation with the regulation of gut microbiota in the old animals [279].…”

Section: Enos Cofactorsmentioning

confidence: 99%

“…Li et al (2021) showed that the administration of icariin (e ), a flavonol glycoside in aged rats, could enhance learning skills and motor coordination. Additionally, the attenuation of components of oxidative stress in numerous biofluids and organelles, and a decrease of pro-inflammatory cytokines and iNOS were exhibited, which also showed a correlation with the regulation of gut microbiota in the old animals [279]. Sun et al (2015) showed that pretreatment of H2O2-treated HUVECs with curcumin (f ) mitigated oxidative stress and apoptosis, and partially restored eNOS phosphorylation, NO bioavailability, and SIRT1 expression [280].…”

Section: Enos Cofactorsmentioning

confidence: 99%

An Overview of NO Signaling Pathways in Aging

et al. 2021

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Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes.

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“…In yeast, Drosophila, Caenorhabditis elegans (C. elegans), mice, and human beings, Sirts are highly expressed and related to lifespan extension [114][115][116]. In old (24-month-age) male C57BL/6J mice, icariin increased the decline of Sirt 1, 3, and 6 proteins induced by ageing in the brain [117].…”

Section: Pharmacodynamics Of Icariin On Ageingmentioning

confidence: 99%

“…Icariin reduces neuronal dysfunction in ageing rats by promoting neuronal autophagy through the AMPK/mTOR/ULK1 pathway [ 119 ]. Icariin could ameliorate the motor and learning disabilities of male C57BL/6J ageing mice by activating Akt/Nrf2/NF-ĸB signaling pathway [ 117 ].…”

Section: Pharmacodynamics Of Icariin On Ageingmentioning

confidence: 99%

The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure

Sethi

Zhang

et al. 2022

Aging

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Epimedium brevicornum Maxim, a Traditional Chinese Medicine, has been used for the treatment of impotence, sinew and bone disorders, "painful impediment caused by wind-dampness," numbness, spasms, hypertension, coronary heart disease, menopausal syndrome, bronchitis, and neurasthenia for many years in China. Recent animal experimental studies indicate that icariin, a major bioactive component of epimedium may effectively treat Alzheimer's disease, cerebral ischemia, depression, Parkinson's disease, multiple sclerosis, as well as delay ageing. Our recent study also suggested that epimedium extract could exhibit radio-neuroprotective effects and prevent ionizing radiation-induced impairment of neurogenesis. This paper reviewed the pharmacodynamics of icariin in treating different neurodegenerative and neuropsychiatric diseases, ageing, and radiation-induced brain damage. The relevant molecular mechanisms and its anti-neuroinflammatory, antiapoptotic, anti-oxidant, as well as pro-neurogenesis roles were also discussed.

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Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice

Cited by 29 publications

References 70 publications

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

An Overview of NO Signaling Pathways in Aging

The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure

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