Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats

Wu, Bin; Chen, Yang; Huang, Jianhua; Ning, You; Bian, Qin; Shan, Yimin; Cai, Wenli; Zhang, Xinming; Zhang, Shen

doi:10.1016/j.jep.2012.05.056

Cited by 49 publications

(33 citation statements)

References 27 publications

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“…Epidemiological studies have suggested the involvement of estrogen insufficiency in cardiovascular, neurodegenerative, and inflammatory diseases (Deroo and Korach, 2006). Epimedium brevicornum and icariin have been reported to protect against heart failure, reduce the inflammatory response, and improve learning and memory, but the mechanisms for these effects are still unknown (Ma et al, 2011;Wu et al, 2012). The estrogenic activity of Epimedium brevicornum supplemented with 10 nM testosterone for a further 24 h and the 17b-estradiol concentration in the culture medium was quantified.…”

Section: Discussionmentioning

confidence: 99%

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Yang

Guo

et al. 2013

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Yang

Guo

et al. 2013

Journal of Ethnopharmacology

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“…The mice's cognitive function was assessed using the Morris water maze (MWM) as previously reported 25,26 . The watermaze consisted of a large circular pool (1.5 m diameter), containing water at around 23±1℃.…”

Section: Morris Water Mazementioning

confidence: 99%

Icariin, a natural flavonol glycoside, extends healthspan in mice

Zhang

Cai

Huang

et al. 2015

Experimental Gerontology

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“…As the major bioactive constituents of Epimedium spp. plants, the total flavonoids showed androgenic, antioxidant, antidepressant, antiosteoporosis, and antitumor activities (Wu et al, 2012;Zhao et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The growth and medicinal quality ofEpimedium wushanenseare improved by an isolate of dark septate fungus

Zhu

Fan

et al. 2015

Pharmaceutical Biology

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Context: Seven dark-septate endophytic (DSE) fungi have been isolated from the roots of Epimedium wushanense T. S. Ying (Berberidaceae), an important medicinal plant with various pharmacological activities. Objective: The current study explores the effects of seven DSE fungi on the growth and accumulation of bioactive compounds in E. wushanense. Materials and methods: Each 1-month-old E. wushanense seedling was inoculated with one of the seven DSE fungi and was grown under greenhouse conditions for 90 d. The molecular identification of the fungi was based on the ITS1-5.8S-ITS2 nuclear ribosomal gene cluster. Results:The results showed that the influence of DSE fungi inoculation varied between strains. Inoculation with DSE8 not only significantly enhanced plant height, root length, leaf area, leaf number, and shoot and root biomass but also improved the total flavonoid and icariin content, with an increase ranging from 20.24% to 237.97%. Three of the seven DSE fungi caused the inoculated plants to die, and the remaining three DSE strains showed neutral or negative effects on plant growth and the accumulation of bioactive compounds. According to the ITS sequence, DSE8 is congeneric to the genus Leptodontidium. Discussion and conclusion: The findings indicate that application of DSE8 may be valuable to facilitate the cultivation of E. wushanense with a higher biomass and improved medicinal quality.

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Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats

Cited by 49 publications

References 27 publications

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Icariin, a natural flavonol glycoside, extends healthspan in mice

The growth and medicinal quality ofEpimedium wushanenseare improved by an isolate of dark septate fungus

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