Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1α in human osteosarcoma cells

Choi, Hee Joung; Eun, Jae-Soon; Kim, Dae Keun; Li, Ri Hua; Shin, Tae‐Yong; Park, Hyunsung; Cho, Nam-Pyo; Soh, Yunjo

doi:10.1016/j.ejphar.2007.10.010

Cited by 48 publications

(26 citation statements)

References 30 publications

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“…14) We have previously reported that IcaS possessed anticancer activity. 15) Similar findings for IcaS have recently been recorded demonstrating that IcaS induced apoptosis by such means as attenuating the HIF-1 protein level in human osteosarcoma cells, 16) suppressing the COX-2/ PGE2 pathway in prostate cancer PC-3 cells, 17) and blocking the STAT3 signaling pathway in U266 multiple myeloma cells. 18) There have also been several reports of other prenylflavonoids derived from Epimedium as an anticancer agent to MCF7 cells, 19,20) Hec1A cells, 21) PC-3 cells, 22) HEPG2 cells, 23,24) SMMC-7721 cells, 25) and SK-Hep-1 cells.…”

supporting

confidence: 54%

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

Huang

Chen

Guo

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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supporting

confidence: 54%

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

Huang

Chen

Guo

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…Baohuoside I (also known as icariside II) is the main active flavonoid component of H. epimedii (Qian et al, 2012;Zhai et al, 2013;Yu et al, 2013;Xiao et al, 2014). Baohuoside I can induce apoptosis in human non-small cell lung cancer cells (NSCLC) via reactive oxygen speciesmediated mitochondrial pathway and also inhibits the growths of U266 multiple myeloma and pre-osteoclastic RAW264.7 cells (Choi et al, 2008;Kim et al, 2011;Jin et al, 2012a;Song et al, 2012;Liu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

et al. 2015

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Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small cell lung cancer (NSCLC) A549 cells.Results showed that the obtained micelles have a mean particle size of around 62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BLSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; halfmaximal inhibitory concentration (IC 50 ) was 6.31 versus 18.28 mg/mL, respectively. The antitumor efficacy test in nude mice showed that BLSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues. The imaging study for in vivo targeting demonstrated that the mixed micelles formulation achieved effective and targeted drug delivery. Therefore, BLSM might be a potential antitumor formulation.

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“…The amount of natural ICS II that could be extracted is as much as 9% (w/w) of total flavonoids from Epimedium koreamum Nakai [4]. Modern pharmacological studies demonstrate that ICS II has many biological activities, including anti-osteoporosis, anti-hypoxia and anti-cancer activities [5][6][7]. In the midst of them, the anti-osteoporosis effect of ICS II is more promising [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

LC Determination of Icariside II in Rat Plasma and Tissues: Application to a Tissue Distribution Study

et al. 2011

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A sensitive and reliable reversed-phase liquid chromatography (RP-LC) with ultraviolet (UV) detection has been developed and validated for the quantification of Icariside II in rat plasma and tissues using Fermononetin as the internal standard. Protein precipitation and liquidliquid extraction were utilized for plasma and tissue sample preparation, respectively. The analysis was successfully carried out on an Agilent SB-C 18 column (5 lm, 4.6 9 250 mm) with the implementation of the following conditions: a mobile phase of phosphoric acid solution (0.1%, v/w)-Acetonitrile (55:45, v/v), a flow rate of 1 mL min -1 , a column temperature of 25°C and a detection wavelength of 270 nm. Good linear relationships of calibration curves were obtained (r 2 [ 0.9906) over the investigated concentration range with plasma and tissue samples. The lower limit of quantification (LLOQ) and the limit of detection (LOD) were 0.1 and 0.02 lg g -1 , respectively (for plasma sample, they were 0.05 and 0.1 lg mL -1 , respectively). The developed method which was embodied with good precision, accuracy, recovery and stability was corroborated to satisfy the requirements for biomedical sample analysis. This method has been successfully applied to tissue distribution study of Icariside II in rats after a single intravenous dose at 12.5 mg kg -1 . Results suggested that Icariside II was distributed to rat tissues rapidly with greater initial concentrations in kidney, lung and liver. Moderate initial distributions were obtained in rat muscle, heart, bone, spleen and plasma. Low amount of Icariside II was detected in testes, and no Icariside II could be detected in the brain.

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Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1α in human osteosarcoma cells

Cited by 48 publications

References 30 publications

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

LC Determination of Icariside II in Rat Plasma and Tissues: Application to a Tissue Distribution Study

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