Icaritin inhibits T cell activation and prolongs skin allograft survival in mice

Li, Xiaojuan; Hu, Yiping; He, Lin; Wang, Song; Zhou, Hua; Liu, Shuwen

doi:10.1016/j.intimp.2012.02.011

Cited by 34 publications

(15 citation statements)

References 35 publications

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“…T-cells are central to the process of transplant rejection through allorecognition of foreign antigens, which leads to their activation and the orchestration of an effector response that results in organ damage [37]. The skin transplant model is a quick and easy method to monitor allogeneic T-cell responses and to evaluate the efficiency of immunosuppressive agents [38]. Isogarcinol significantly improved allogeneic skin graft rejection time in mice.…”

Section: Discussionmentioning

confidence: 99%

Isogarcinol Is a New Immunosuppressant

et al. 2013

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Calcineurin (CN), a unique protein phosphatase, plays an important role in immune regulation. In this study we used CN as a target enzyme to investigate the immunosuppressive properties of a series of natural compounds from Garcinia mangostana L., and discovered an active compound, isogarcinol. Enzymatic assays showed that isogarcinol inhibited CN in a dose-dependent manner. At concentrations resulting in relatively low cytotoxicity isogarcinol significantly inhibited proliferation of murine spleen T-lymphocytes induced by concanavalin A (ConA) and the mixed lymphocyte reaction (MLR). In addition, it performed much better in acute toxicity tests and via oral administration in mice than cyclosporin A (CsA), with few adverse reactions and low toxicity in experimental animals. Oral administration of isogarcinol in mice resulted in a dose-dependent decrease in delayed type hypersensitivity (DTH) and prolonged graft survival in allogeneic skin transplantation. These findings suggest that isogarcinol could serve as a new oral immunomodulatory drug for preventing transplant rejection, and for long-term medication in autoimmune diseases.

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Section: Discussionmentioning

confidence: 99%

Isogarcinol Is a New Immunosuppressant

et al. 2013

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“…Icaritin (25 M) interferes with T cell activation by inhibiting the proliferation of CD4 þ T cells and down-regulating CD25, IL-2, and interferon-expression to treat Th1-dominated immune diseases (Li et al, 2012c).…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo)

Chen

Tang

et al. 2015

Am. J. Chin. Med.

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Epimedii Folium (Yinyanghuo in Chinese) is one of the most commonly used traditional Chinese medicines. Its main active components are flavonoids, which exhibit multiple biological activities, such as promotion of bone formation and sexual function, protection of the nervous system, and prevention of cardiovascular diseases. Flavonoids also show anti-inflammatory and anticancer effects. Various effective methods, including genetic and chemical approaches, have been developed for the quality control of Yinyanghuo. In this review, the studies conducted in the last decade about the chemical constituents, quality control, and bioactivity of Yinyanghuo are summarized and discussed.

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“…For example, flavonoids, the major constituents in Epimedium which including baohuoside II, baohuoside I, epimedin A, epimedin B, epimedin C, quercitrin, sagittatoside A, sagittatoside B, hyperoside, icariside I, icariin and astragalin, have been widely used for improving cardiovascular and promoting sexual function [ 5 , 6 ]. They also show anti-osteoporosis, anti-inflammation, anti-cancer and anti-oxidation effects [ 7 , 8 , 9 , 10 , 11 ]. Meanwhile, the phenolic acids such as chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid have extensive pharmacological actions including anti-inflammation, anti-fatigue and antitumor properties [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Active Compositions between Raw and Processed Epimedium from Different Species

et al. 2018

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Epimedium herb is one of the most vital traditional Chinese medicines (TCMs), which is used for “nourishing the kidney and reinforcing the Yang”. In the guidance of TCM theory, Epimedium herb is usually processed with lamb oil to increase its efficacy. The contents of active ingredients in different Epimedium are significantly varied, which may derive from their different species, regions and processing methods. In this research, 13 batches of raw Epimedium collected from 6 provinces were identified. After optimization of the processing method of Epimedium, a liquid chromatography–mass spectrometry (LC–MS/MS) method for simultaneous determination of 16 compounds was established to evaluate the quality of raw and processed. Then the multivariate statistical technique was applied to compare different batches of Epimedium based on the LC–MS/MS data. As a conclusion, the herbs collected from 6 areas were ascribed to 5 species by microscopic and appearance features. Meanwhile, all of the raw and processed samples were classified by partial least squares discriminant analysis (PLS-DA) based on the 16 analyzed compounds. The comparison results indicate that processing and species both have important influences on Epimedium compositions contents.

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Icaritin inhibits T cell activation and prolongs skin allograft survival in mice

Cited by 34 publications

References 35 publications

Isogarcinol Is a New Immunosuppressant

Isogarcinol Is a New Immunosuppressant

Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo)

Comparison of the Active Compositions between Raw and Processed Epimedium from Different Species

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