ICCM2015(Paper ID:1148): DPD Simulation of the Movement and Deformation of Bioconcave Cells

Abstract

This paper presents a dissipative particle dynamics (DPDs) method for investigating the movement and deformation of biconcave shape red blood cells (RBCs) with the worm-like chain (WLC) bead spring. First, the stretching of a RBC is modeled and the obtained shape evolution of the cell agrees well with experimental results. Second, the movement and deformation of a RBC in shear flows are investigated and three typical modes (tumbling, intermittent and tank-treading) are observed. Lastly, an illustrating example of multi-RBCs in Poiseuille flow in a tube is simulated. We conclude that the presented DPD method with WLC spring can effectively model the movement and deformation of bioconcave cells.

Numerical investigation on red blood cell flow based on unstructured grid

“…28 However, most of mesh-based methods are based on structured grid, which may yield low numerical accuracy of RBC flow in complex geometry, and the research of RBC model based on unstructured grid is still insufficient for the blood flow in complex region. Particle-based methods are widely-used in RBCs simulations in recent years, because of the ease and flexibility in modeling complex structure fluids, including DPD, 10,21,29 smoothed particle hydrodynamics (SPH), 30 lattice Boltzmann method (LBM), 4,6,31 and moving particle semi-implicit method (MPS), 12,18,32 and smooth DPD (SDPD). 33 However, its computational cost is often higher than that of the mesh-based method, and numerical oscillation usually induces the self-diffusion of particles.…”

A two-component model of the red blood cell membrane and other mathematical models in medicine

“…We observe that in addition we include an second term to express the repulsive force (for n > 0) between neighboring nodes, concerning the so-called power force (POW). We denote therefore the formulation (3.3) as WLC-POW model XIAO et al, 2016;YUN;XIANG;WANG, 2018) and, a nonzero equilibrium spring length is defined by the balance of these two forces (ZHOU et al, 2016).…”